Severe isoniazid related sideroblastic anemia

Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were...

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Bibliographic Details
Published in:Hematology Reports
Main Authors: Rein Jan Piso, Kveti Kriz, Marie-Claire Desax
Format: Article
Language:English
Published: MDPI AG 2011-01-01
Subjects:
sideroblastic anemia
Isoniazid, Tuberculosis
Online Access:http://www.pagepress.org/journals/index.php/hr/article/view/2072
Description
Summary:Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were very low (reticulocyte production index of 0.48), but bone marrow aspirate showed an accelerated erythropoiesis with ringsideroblasts. Anaemia rapidly resolved after cessation of Isoniazid. We postulate an Isoniazid induced inhibition of the δ-Amino-levulinat-synthase resulting in marked depletion of heam synthesis.
ISSN:2038-8322
2038-8330

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