Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels

Abstract Background Neurodegeneration with brain iron accumulation (NBIA) disorders are a group of neurodegenerative diseases that have in common the accumulation of iron in the basal nuclei of the brain which are essential components of the extrapyramidal system. Frequent symptoms are progressive s...

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Bibliographic Details

Published in:	Orphanet Journal of Rare Diseases
Main Authors:	Marta Talaverón-Rey, Mónica Álvarez-Córdoba, Irene Villalón-García, Suleva Povea-Cabello, Juan M. Suárez-Rivero, David Gómez-Fernández, Ana Romero-González, Alejandra Suárez-Carrillo, Manuel Munuera-Cabeza, Paula Cilleros-Holgado, Diana Reche-López, Rocío Piñero-Pérez, José A. Sánchez-Alcázar
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Subjects:	Pantothenate kinase PANK2 Pantothenate kinase-associated neurodegeneration PKAN Coenzyme A Mitochondria
Online Access:	https://doi.org/10.1186/s13023-023-02687-5