Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts

Abstract Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left ventricular reverse remodeling (LVRR). Currently, the detailed association between genotyp...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Keiichi Hirono, Yukiko Hata, Shojiro Ichimata, Naoki Nishida, Teruhiko Imamura, Yoshihiro Asano, Yuki Kuramoto, Kaori Tsuboi, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka Ozawa, Jun Muneuchi, Kazushi Yasuda, Kotaro Urayama, Hideharu Oka, Tomoyuki Miyamoto, Kenji Baba, Akio Kato, Hirofumi Saiki, Naoki Kuwabara, Masako Harada, Shiro Baba, Mari Morikawa, Hidenori Iwasaki, Yuichiro Hirata, Yuki Ito, Heima Sakaguchi, Susumu Urata, Koichi Toda, Emi Kittaka, Seigo Okada, Yohei Hasebe, Shinsuke Hoshino, Takanari Fujii, Norie Mitsushita, Masaki Nii, Kayo Ogino, Mitsuhiro Fujino, Yoko Yoshida, Yutaka Fukuda, Satoru Iwashima, Kiyohiro Takigiku, Yasushi Sakata, Ryo Inuzuka, Jun Maeda, Yasunobu Hayabuchi, Tao Fujioka, Hidemasa Namiki, Shuhei Fujita, Koichi Nishida, Ayako Kuraoka, Nobuhiko Kan, Sachiko Kido, Ken Watanabe, Fukiko Ichida
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-12-01
Subjects:	Dilated cardiomyopathy Heart failure Genetics Sarcomere gene Left ventricular reverse remodeling
Online Access:	https://doi.org/10.1038/s41598-024-77360-3