Motility of Different Gastric <i>Helicobacter</i> spp.

• Published in: Microorganisms
• Main Authors: Rama Bansil, Maira A. Constantino, Clover Su-Arcaro, Wentian Liao, Zeli Shen, James G. Fox
• Format: Article
• Language: English
• Published: MDPI AG 2023-03-01
• Subjects: flagella; <i>Helicobacter</i>; motility; unipolar bacteria; bipolar bacteria; gastric mucin
• Online Access: https://www.mdpi.com/2076-2607/11/3/634

<i>Helicobacter</i> spp., including the well-known human gastric pathogen <i>H. pylori</i>, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. The flagella of different <i>Helicobacter</i> spp. vary in their location and number. This review focuses on the swimming characteristics of different species with different flagellar architectures and cell shapes. All <i>Helicobacter</i> spp. use a run-reverse-reorient mechanism to swim in aqueous solutions, as well as in gastric mucin. Comparisons of different strains and mutants of <i>H. pylori</i> varying in cell shape and the number of flagella show that their swimming speed increases with an increasing number of flagella and is somewhat enhanced with a helical cell body shape. The swimming mechanism of <i>H. suis</i>, which has bipolar flagella, is more complex than that of unipolar <i>H. pylori. H. suis</i> exhibits multiple modes of flagellar orientation while swimming. The pH-dependent viscosity and gelation of gastric mucin significantly impact the motility of <i>Helicobacter</i> spp. In the absence of urea, these bacteria do not swim in mucin gel at pH < 4, even though their flagellar bundle rotates.