Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy
Diabetic nephropathy is a common chronic microvascular complication in diabetic patients. Mesangial cell is the main cell type in glomeruli. High glucose stimulation can promote mesangial cell proliferation by reducing endogenous hydrogen sulfide concentration, activating transforming growth factor-...
| Published in: | Jichu yixue yu linchuang |
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| Main Author: | |
| Format: | Article |
| Language: | Chinese |
| Published: |
Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2021-10-01
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| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a200815.pdf |
| _version_ | 1850002958742192128 |
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| author | SUN Feng-qi, WU Ren, CHANG Gui-quan, LI Hong-zhu |
| author_facet | SUN Feng-qi, WU Ren, CHANG Gui-quan, LI Hong-zhu |
| author_sort | SUN Feng-qi, WU Ren, CHANG Gui-quan, LI Hong-zhu |
| collection | DOAJ |
| container_title | Jichu yixue yu linchuang |
| description | Diabetic nephropathy is a common chronic microvascular complication in diabetic patients. Mesangial cell is the main cell type in glomeruli. High glucose stimulation can promote mesangial cell proliferation by reducing endogenous hydrogen sulfide concentration, activating transforming growth factor-β superfamily and influencing long non-coding RNA level. Abnormal activation of mesangial cells plays an important role in the pathogenesis of diabetic glomerulosclerosis. |
| format | Article |
| id | doaj-art-ab604aec0ff34097bc65bc73ef57862d |
| institution | Directory of Open Access Journals |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2021-10-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| spelling | doaj-art-ab604aec0ff34097bc65bc73ef57862d2025-08-20T00:48:13ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252021-10-01411015101513Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathySUN Feng-qi, WU Ren, CHANG Gui-quan, LI Hong-zhu0Department of Pathophysiology, School of Basic Medicine,Harbin Medical University, Harbin 150086, ChinaDiabetic nephropathy is a common chronic microvascular complication in diabetic patients. Mesangial cell is the main cell type in glomeruli. High glucose stimulation can promote mesangial cell proliferation by reducing endogenous hydrogen sulfide concentration, activating transforming growth factor-β superfamily and influencing long non-coding RNA level. Abnormal activation of mesangial cells plays an important role in the pathogenesis of diabetic glomerulosclerosis.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a200815.pdfdiabetic nephropathy|glomerulosclerosis|high glucose|mesangial cell |
| spellingShingle | SUN Feng-qi, WU Ren, CHANG Gui-quan, LI Hong-zhu Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy diabetic nephropathy|glomerulosclerosis|high glucose|mesangial cell |
| title | Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy |
| title_full | Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy |
| title_fullStr | Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy |
| title_full_unstemmed | Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy |
| title_short | Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy |
| title_sort | research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy |
| topic | diabetic nephropathy|glomerulosclerosis|high glucose|mesangial cell |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a200815.pdf |
| work_keys_str_mv | AT sunfengqiwurenchangguiquanlihongzhu researchprogressontheroleofglomerularmesangialcellproliferationinglomerulosclerosisofdiabeticnephropathy |