Engineering nano‐clustered multivalent agonists to cross‐link TNF receptors for cancer therapy

Abstract Tumor necrosis factor receptors (TNFRs) are promising targets for cancer therapy. However, activating their downstream signaling requires cross‐linking of TNFRs. Herein, to devise strong agonists of TNFRs, ligands targeting TNFRs, such as OX40L and tumor necrosis factor‐related apoptosis‐in...

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Bibliographic Details
Published in:	Aggregate
Main Authors:	Yue Zhang, Gui Zhao, Yi‐Fang Chen, Shi‐Kun Zhou, Yue Wang, Yi‐Qun Sun, Song Shen, Cong‐Fei Xu, Jun Wang
Format:	Article
Language:	English
Published:	Wiley 2023-12-01
Subjects:	antibody cancer therapy drug delivery nanoparticle TNFR
Online Access:	https://doi.org/10.1002/agt2.393

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