Endogenous Controls for the Evaluation of Osteoarthritis-Related miRNAs in Extracellular Vesicles from Bone-Marrow-Derived Mesenchymal Stromal Cells and the Impact of Osteoarthritis Synovial Fluid
Bone-marrow-derived stromal cells (BMSCs) have emerged as promising therapeutic option for the treatment of osteoarthritis (OA) due to their tissue regenerative and anti-inflammatory features. BMSCs’ clinical potential is mainly ascribed to their released factors and extracellular vesicles (EVs), wh...
| Published in: | Biomolecules |
|---|---|
| Main Authors: | Enrico Ragni, Carlotta Perucca Orfei, Marco Viganò, Federico Valli, Laura de Girolamo |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/2/316 |
Similar Items
Molecular Characterization of Secreted Factors and Extracellular Vesicles-Embedded miRNAs from Bone Marrow-Derived Mesenchymal Stromal Cells in Presence of Synovial Fluid from Osteoarthritis Patients
by: Enrico Ragni, et al.
Published: (2022-11-01)
by: Enrico Ragni, et al.
Published: (2022-11-01)
Cartilage Protective and Immunomodulatory Features of Osteoarthritis Synovial Fluid-Treated Adipose-Derived Mesenchymal Stem Cells Secreted Factors and Extracellular Vesicles-Embedded miRNAs
by: Enrico Ragni, et al.
Published: (2021-04-01)
by: Enrico Ragni, et al.
Published: (2021-04-01)
Secreted Factors and Extracellular Vesicles Account for the Immunomodulatory and Tissue Regenerative Properties of Bone-Marrow-Derived Mesenchymal Stromal Cells for Osteoarthritis
by: Enrico Ragni, et al.
Published: (2022-11-01)
by: Enrico Ragni, et al.
Published: (2022-11-01)
Joint Tissue Protective and Immune-Modulating miRNA Landscape of Mesenchymal Stromal Cell-Derived Extracellular Vesicles under Different Osteoarthritis-Mimicking Conditions
by: Enrico Ragni, et al.
Published: (2022-07-01)
by: Enrico Ragni, et al.
Published: (2022-07-01)
miRNA Reference Genes in Extracellular Vesicles Released from Amniotic Membrane-Derived Mesenchymal Stromal Cells
by: Enrico Ragni, et al.
Published: (2020-04-01)
by: Enrico Ragni, et al.
Published: (2020-04-01)
miR-103a-3p and miR-22-5p Are Reliable Reference Genes in Extracellular Vesicles From Cartilage, Adipose Tissue, and Bone Marrow Cells
by: Enrico Ragni, et al.
Published: (2021-02-01)
by: Enrico Ragni, et al.
Published: (2021-02-01)
Adipose-Derived Mesenchymal Stromal Cells Treated with Interleukin 1 Beta Produced Chondro-Protective Vesicles Able to Fast Penetrate in Cartilage
by: Alessandra Colombini, et al.
Published: (2021-05-01)
by: Alessandra Colombini, et al.
Published: (2021-05-01)
Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis
by: Pooja N. Swami, et al.
Published: (2024-12-01)
by: Pooja N. Swami, et al.
Published: (2024-12-01)
Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction
by: Clara Sanjurjo-Rodriguez, et al.
Published: (2020-10-01)
by: Clara Sanjurjo-Rodriguez, et al.
Published: (2020-10-01)
Amniotic membrane‐mesenchymal stromal cells secreted factors and extracellular vesicle‐miRNAs: Anti‐inflammatory and regenerative features for musculoskeletal tissues
by: Enrico Ragni, et al.
Published: (2021-07-01)
by: Enrico Ragni, et al.
Published: (2021-07-01)
Characterization of microRNA Levels in Synovial Fluid from Knee Osteoarthritis and Anterior Cruciate Ligament Tears
by: Laura Rizzi, et al.
Published: (2022-11-01)
by: Laura Rizzi, et al.
Published: (2022-11-01)
Exploration of Exosomal miRNAs from Serum and Synovial Fluid in Arthritis Patients
by: Yingying Xie, et al.
Published: (2022-01-01)
by: Yingying Xie, et al.
Published: (2022-01-01)
Effects of synovial macrophages in osteoarthritis
by: Kun Zhao, et al.
Published: (2023-07-01)
by: Kun Zhao, et al.
Published: (2023-07-01)
Understanding the effects of mesenchymal stromal cell therapy for treating osteoarthritis using an in vitro co-culture model
by: V Shang, et al.
Published: (2023-05-01)
by: V Shang, et al.
Published: (2023-05-01)
Impact of Isolation Procedures on the Development of a Preclinical Synovial Fibroblasts/Macrophages in an In Vitro Model of Osteoarthritis
by: Cristina Manferdini, et al.
Published: (2020-12-01)
by: Cristina Manferdini, et al.
Published: (2020-12-01)
Biomarkers associated with synovial membrane aging in osteoarthritis
by: Danning Mao, et al.
Published: (2025-06-01)
by: Danning Mao, et al.
Published: (2025-06-01)
Differential miRNA expression profiles in the bone marrow of Beagle dogs at different stages of Toxocara canis infection
by: Jin Gao, et al.
Published: (2022-12-01)
by: Jin Gao, et al.
Published: (2022-12-01)
The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence
by: Susanne N. Wijesinghe, et al.
Published: (2022-09-01)
by: Susanne N. Wijesinghe, et al.
Published: (2022-09-01)
Synovial tissue metabolomic profiling reveal biomarkers of synovial inflammation in patients with osteoarthritis
by: Jessica D. Murillo-Saich, et al.
Published: (2022-09-01)
by: Jessica D. Murillo-Saich, et al.
Published: (2022-09-01)
Differential Expression Profiles of the Transcriptome and miRNA Interactome in Synovial Fibroblasts of Rheumatoid Arthritis Revealed by Next Generation Sequencing
by: Chia-Chun Tseng, et al.
Published: (2019-08-01)
by: Chia-Chun Tseng, et al.
Published: (2019-08-01)
Data Integration Reveals the Potential Biomarkers of Circulating MicroRNAs in Osteoarthritis
by: Thuan Duc Lao, et al.
Published: (2021-02-01)
by: Thuan Duc Lao, et al.
Published: (2021-02-01)
Bibliometric analysis of synovial in osteoarthritis in the last 10 years
by: Guangtao Han, et al.
Published: (2024-07-01)
by: Guangtao Han, et al.
Published: (2024-07-01)
The Usefulness of Synovial Fluid Proteome Analysis in Orthopaedics: Focus on Osteoarthritis and Periprosthetic Joint Infections
by: Davide Bizzoca, et al.
Published: (2022-10-01)
by: Davide Bizzoca, et al.
Published: (2022-10-01)
The potential role of synovial cells in the progression and treatment of osteoarthritis
by: Zaijun Zou, et al.
Published: (2023-10-01)
by: Zaijun Zou, et al.
Published: (2023-10-01)
Exploring the roles of snoRNA-induced ribosome heterogeneity in equine osteoarthritis
by: Alzbeta Chabronova, et al.
Published: (2025-07-01)
by: Alzbeta Chabronova, et al.
Published: (2025-07-01)
Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair
by: Yujie Song, et al.
Published: (2022-05-01)
by: Yujie Song, et al.
Published: (2022-05-01)
Proteomic Analysis of Female Synovial Fluid to Identify Novel Biomarkers for Osteoarthritis
by: P. Robinson Muller, et al.
Published: (2023-02-01)
by: P. Robinson Muller, et al.
Published: (2023-02-01)
Insights into Inflammatory Priming of Adipose-Derived Mesenchymal Stem Cells: Validation of Extracellular Vesicles-Embedded miRNA Reference Genes as A Crucial Step for Donor Selection
by: Enrico Ragni, et al.
Published: (2019-04-01)
by: Enrico Ragni, et al.
Published: (2019-04-01)
The effect of hypoxia on chondrogenesis of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells
by: Alexis L. Gale, et al.
Published: (2019-06-01)
by: Alexis L. Gale, et al.
Published: (2019-06-01)
Synovial Chondromatosis in Woman with Symptoms Mimicking Early Stages Osteoarthritis: Case Report
by: Bagus Wibowo Soetojo, et al.
Published: (2020-01-01)
by: Bagus Wibowo Soetojo, et al.
Published: (2020-01-01)
Synovial mast cells and osteoarthritis: Current understandings and future perspectives
by: Guanghui Hao, et al.
Published: (2024-12-01)
by: Guanghui Hao, et al.
Published: (2024-12-01)
Impact of the Process Variables on the Yield of Mesenchymal Stromal Cells from Bone Marrow Aspirate Concentrate
by: Madhan Jeyaraman, et al.
Published: (2022-01-01)
by: Madhan Jeyaraman, et al.
Published: (2022-01-01)
Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components
by: Fani Roumelioti, et al.
Published: (2024-09-01)
by: Fani Roumelioti, et al.
Published: (2024-09-01)
Identification of key biomarkers and immune infiltration in the synovial tissue of osteoarthritis by bioinformatics analysis
by: Weisong Cai, et al.
Published: (2020-01-01)
by: Weisong Cai, et al.
Published: (2020-01-01)
GPx3 marks adipocyte lineage commitment in bone marrow stromal cells
by: Zhongxiang Wang, et al.
Published: (2025-05-01)
by: Zhongxiang Wang, et al.
Published: (2025-05-01)
Small extracellular vesicles derived from synovial fibroblasts contain distinct miRNA profiles and contribute to chondrocyte damage in osteoarthritis
by: Sabha Asghar, et al.
Published: (2024-09-01)
by: Sabha Asghar, et al.
Published: (2024-09-01)
Immunomodulatory potential of secretome from cartilage cells and mesenchymal stromal cells in an arthritic context: From predictive fiction toward reality
by: Alessandra Colombini, et al.
Published: (2022-10-01)
by: Alessandra Colombini, et al.
Published: (2022-10-01)
Age-related changes in human bone marrow mesenchymal stromal cells: morphology, gene expression profile, immunomodulatory activity and miRNA expression
by: Fulvio Massaro, et al.
Published: (2023-12-01)
by: Fulvio Massaro, et al.
Published: (2023-12-01)
Comparison of the Chondrogenic Differentiation Potential of Equine Synovial Membrane-Derived and Bone Marrow-Derived Mesenchymal Stem Cells
by: Alexis L. Gale, et al.
Published: (2019-06-01)
by: Alexis L. Gale, et al.
Published: (2019-06-01)
Progesterone Levels During Pregnancy in Ewes Treated with Bone Marrow Stromal Cells
by: A.A.Omar, et al.
Published: (2019-12-01)
by: A.A.Omar, et al.
Published: (2019-12-01)
Similar Items
-
Molecular Characterization of Secreted Factors and Extracellular Vesicles-Embedded miRNAs from Bone Marrow-Derived Mesenchymal Stromal Cells in Presence of Synovial Fluid from Osteoarthritis Patients
by: Enrico Ragni, et al.
Published: (2022-11-01) -
Cartilage Protective and Immunomodulatory Features of Osteoarthritis Synovial Fluid-Treated Adipose-Derived Mesenchymal Stem Cells Secreted Factors and Extracellular Vesicles-Embedded miRNAs
by: Enrico Ragni, et al.
Published: (2021-04-01) -
Secreted Factors and Extracellular Vesicles Account for the Immunomodulatory and Tissue Regenerative Properties of Bone-Marrow-Derived Mesenchymal Stromal Cells for Osteoarthritis
by: Enrico Ragni, et al.
Published: (2022-11-01) -
Joint Tissue Protective and Immune-Modulating miRNA Landscape of Mesenchymal Stromal Cell-Derived Extracellular Vesicles under Different Osteoarthritis-Mimicking Conditions
by: Enrico Ragni, et al.
Published: (2022-07-01) -
miRNA Reference Genes in Extracellular Vesicles Released from Amniotic Membrane-Derived Mesenchymal Stromal Cells
by: Enrico Ragni, et al.
Published: (2020-04-01)
