Prognostic scores in primary biliary cholangitis

Aim: Evaluating prognostic scores' utility in predicting ursodeoxycholic acid (UDCA) biochemical response (BR) and long-term liver-related complications in primary biliary cholangitis (PBC) patients. Patients & methods: This retrospective single-center study included 50 predominantly female...

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Bibliographic Details
Published in:Future Science OA
Main Authors: Ramzi Tababi, Soumaya Mrabet, Imen Akkari, Raida Harbi, Elhem Ben Jazia
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Subjects:
predictive scores
primary biliary cholangitis
prognosis
treatment response
ursodeoxycholic acid
Online Access:https://www.tandfonline.com/doi/10.2144/fsoa-2023-0203
Description
Summary:Aim: Evaluating prognostic scores' utility in predicting ursodeoxycholic acid (UDCA) biochemical response (BR) and long-term liver-related complications in primary biliary cholangitis (PBC) patients. Patients & methods: This retrospective single-center study included 50 predominantly female PBC patients (median age: 56) on UDCA treatment. BR was defined by Paris II criteria. Liver-related complications during a median 76-month follow-up were assessed. APRI, ALBI, Mayo, GLOBE and UK-PBC scores were calculated. Results: 64% achieved BR, while 40% experienced liver-related complications. All scores showed good BR prediction (concordance statistics: 0.76–0.94) and excellent negative predictive values for 5-year liver complications (concordance statistics: 0.73–0.89). Conclusion: Implementing these scores in clinical practice is encouraged due to their effectiveness in predicting BR- and liver-related events.
ISSN:2056-5623

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