Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces.

In the biosynthesis of polyketides, ketoreductases (KRs) are an important group of enzymes that determine the chiralities of the carbon backbones. SiaM is a special member of this group that can recognize substrates with different lengths and can be used iteratively. Here we report the crystal struc...

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Bibliographic Details
Published in:	PLoS ONE
Main Authors:	Hua Wang, Huaidong Zhang, Yi Zou, Yanling Mi, Shuangjun Lin, Zhixiong Xie, Yunjun Yan, Houjin Zhang
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Online Access:	http://europepmc.org/articles/PMC4046962?pdf=render

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