miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma
Immune checkpoint inhibitors are a promising therapy for the treatment of cancers, including melanoma, that improved benefit clinical outcomes. However, a subset of melanoma patients do not respond or acquire resistance to immunotherapy, which limits their clinical applicability. Recent studies have...
| Published in: | Biomolecules |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/11/1648 |
| _version_ | 1850103548935667712 |
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| author | Mai-Huong Thi Nguyen Yueh-Hsia Luo An-Lun Li Jen-Chieh Tsai Kun-Lin Wu Pei-Jung Chung Nianhan Ma |
| author_facet | Mai-Huong Thi Nguyen Yueh-Hsia Luo An-Lun Li Jen-Chieh Tsai Kun-Lin Wu Pei-Jung Chung Nianhan Ma |
| author_sort | Mai-Huong Thi Nguyen |
| collection | DOAJ |
| container_title | Biomolecules |
| description | Immune checkpoint inhibitors are a promising therapy for the treatment of cancers, including melanoma, that improved benefit clinical outcomes. However, a subset of melanoma patients do not respond or acquire resistance to immunotherapy, which limits their clinical applicability. Recent studies have explored the reasons related to the resistance of melanoma to immune checkpoint inhibitors. Of note, miRNAs are the regulators of not only cancer progression but also of the response between cancer cells and immune cells. Investigation of miRNA functions within the tumor microenvironment have suggested that miRNAs could be considered as key partners in immunotherapy. Here, we reviewed the known mechanism by which melanoma induces resistance to immunotherapy and the role of miRNAs in immune responses and the microenvironment. |
| format | Article |
| id | doaj-art-ae1ff9ce822d4e288d12818cefbb94dc |
| institution | Directory of Open Access Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-ae1ff9ce822d4e288d12818cefbb94dc2025-08-20T00:03:24ZengMDPI AGBiomolecules2218-273X2021-11-011111164810.3390/biom11111648miRNA as a Modulator of Immunotherapy and Immune Response in MelanomaMai-Huong Thi Nguyen0Yueh-Hsia Luo1An-Lun Li2Jen-Chieh Tsai3Kun-Lin Wu4Pei-Jung Chung5Nianhan Ma6Department of Biomedical Sciences and Engineering, National Central University, Taoyuan 320317, TaiwanDepartment of Life Sciences, National Central University, Taoyuan 320317, TaiwanDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan 320317, TaiwanInstitute of Biotechnology, National Tsing Hua University, Hsinchu 300044, TaiwanDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan 320317, TaiwanDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan 320317, TaiwanDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan 320317, TaiwanImmune checkpoint inhibitors are a promising therapy for the treatment of cancers, including melanoma, that improved benefit clinical outcomes. However, a subset of melanoma patients do not respond or acquire resistance to immunotherapy, which limits their clinical applicability. Recent studies have explored the reasons related to the resistance of melanoma to immune checkpoint inhibitors. Of note, miRNAs are the regulators of not only cancer progression but also of the response between cancer cells and immune cells. Investigation of miRNA functions within the tumor microenvironment have suggested that miRNAs could be considered as key partners in immunotherapy. Here, we reviewed the known mechanism by which melanoma induces resistance to immunotherapy and the role of miRNAs in immune responses and the microenvironment.https://www.mdpi.com/2218-273X/11/11/1648immunotherapyresistancemiRNAbiomarker |
| spellingShingle | Mai-Huong Thi Nguyen Yueh-Hsia Luo An-Lun Li Jen-Chieh Tsai Kun-Lin Wu Pei-Jung Chung Nianhan Ma miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma immunotherapy resistance miRNA biomarker |
| title | miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma |
| title_full | miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma |
| title_fullStr | miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma |
| title_full_unstemmed | miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma |
| title_short | miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma |
| title_sort | mirna as a modulator of immunotherapy and immune response in melanoma |
| topic | immunotherapy resistance miRNA biomarker |
| url | https://www.mdpi.com/2218-273X/11/11/1648 |
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