Inner Ear Delivery of Polyamino Acid Nanohydrogels Loaded with Dexamethasone

ObjectiveTo develop a novel polyamino acid-based nanohydrogel drug delivery system for dexamethasone to enhance its delivery efficiency to the inner ear.MethodsA fluorescein-labeled polyglutamic acid-based polyamino acid dexamethasone nanohydrogel was synthesized, and its gelation time was measured....

Full description

Bibliographic Details
Published in:	Xiehe Yixue Zazhi
Main Authors:	AI Pingping, ZHAO Lidong, TANG Zhaohui, HE Chaoliang, CHEN Xuesi, YANG Shiming, WU Nan
Format:	Article
Language:	Chinese
Published:	Editorial Office of Medical Journal of Peking Union Medical College Hospital 2025-02-01
Subjects:	polyamino acid nanohydrogel dexamethasone otology pharmacokinetics
Online Access:	https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0455

Similar Items

Cyclodextrin-Based Nanohydrogels Containing Polyamidoamine Units: A New Dexamethasone Delivery System for Inflammatory Diseases
by: Monica Argenziano, et al.
Published: (2017-06-01)

Milk Protein-Based Nanohydrogels: Current Status and Applications
by: Manpreet Kaur, et al.
Published: (2022-07-01)

Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery
by: Maria Tannous, et al.
Published: (2022-08-01)

Potent anti-tumor immunostimulatory biocompatible nanohydrogel made from DNA
by: Jiana Jiang, et al.
Published: (2019-06-01)

Improved Solubility and Activity of Natural Product in Nanohydrogel
by: Uce Lestari, et al.
Published: (2023-12-01)

Semicircular canal drug delivery safely targets the inner ear perilymphatic space
by: Jinkyung Kim, et al.
Published: (2024-11-01)

A New Strategy for Nucleic Acid Delivery and Protein Expression Using Biocompatible Nanohydrogels of Predefined Sizes
by: Lakshmanan Eswaran, et al.
Published: (2023-03-01)

Preparation and Antibacterial Activity of Thermo-Responsive Nanohydrogels from Qiai Essential Oil and Pluronic F108
by: Jianfeng Zhan, et al.
Published: (2021-09-01)

New Biocompatible Nanohydrogels of Predefined Sizes for Complexing Nucleic Acids
by: Lakshmanan Eswaran, et al.
Published: (2023-01-01)

A pH-Responsive Dendritic-DNA-Based Nanohydrogel for Dual Drug Delivery
by: Jing Zhao, et al.
Published: (2025-04-01)

Development of a New Hyaluronic Acid Based Redox-Responsive Nanohydrogel for the Encapsulation of Oncolytic Viruses for Cancer Immunotherapy
by: Siyuan Deng, et al.
Published: (2021-01-01)

Characteristics of novel polymer based on pseudo-polyamino acids GluLa-DPG-PEG600: binding of albumin, biocompatibility, biodistribution and potential crossing the blood-brain barrier in rats
by: B. O. Chekh, et al.
Published: (2017-08-01)

Influence of Selected Factors on the Adsorption Layer Structure of Polyamino Acids and Their Block Copolymers at the Solid–Aqueous Solution Interface
by: Iwona Ostolska, et al.
Published: (2023-12-01)

Fabrication and Characterization of Taro (<i>Colocasia esculenta</i>)-Mucilage-Based Nanohydrogel for Shelf-Life Extension of Fresh-Cut Apples
by: Mansuri M. Tosif, et al.
Published: (2024-01-01)

In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles
by: Leonard Kaps, et al.
Published: (2020-08-01)

Anticancer Efficacy of 5-Fluorouracil-Loaded Chitin Nanohydrogel in Enhanced Skin Cancer Therapy
by: Yuvraj D. Dange, et al.
Published: (2025-07-01)

Voriconazole-Loaded Nanohydrogels Towards Optimized Antifungal Therapy for Cystic Fibrosis Patients
by: Shaul D. Cemal, et al.
Published: (2025-05-01)

Biofilm targeting with chitosan-based nanohydrogel containing Quercus infectoria G. Olivier extract against Streptococcus mutans: new formulations of a traditional natural product
by: Yasin Karimi, et al.
Published: (2024-11-01)

ROS‐Activated Nanohydrogel Scaffolds with Multi‐Factors Controlled Release for Targeted Dual‐Lineage Repair of Osteochondral Defects
by: Xiuhui Wang, et al.
Published: (2025-05-01)

Effect of chitosan/dioleyl phosphatidyl ethanolamine - Baicalein nanohydrogel in the treatment of rat with periodontitis
by: Lihua Guo, et al.
Published: (2024-02-01)

Effect of Hydrophobic Polypeptide Length on Performances of Thermo-Sensitive Hydrogels
by: Jiandong Han, et al.
Published: (2018-04-01)

Synthesis and Characterization of Sulfur Nanoparticles of <i>Citrus limon</i> Extract Embedded in Nanohydrogel Formulation: In Vitro and In Vivo Studies
by: Hadia Baloch, et al.
Published: (2023-04-01)

Dexamethasone for Inner Ear Therapy: Biocompatibility and Bio-Efficacy of Different Dexamethasone Formulations In Vitro
by: Ziwen Gao, et al.
Published: (2021-12-01)

Nanoparticle delivery of TFOs is a novel targeted therapy for HER2 amplified breast cancer
by: Xiaojing Yang, et al.
Published: (2023-07-01)

The pharmacokinetics of phenylbutazone and its interaction with dexamethasone in chicks
by: Sahar K. Abdulhamid, et al.
Published: (2023-01-01)

Amino acid modified OCMC-g-Suc-β-CD nanohydrogels carrying lapatinib and ginsenoside Rg1 exhibit high anticancer activity in a zebrafish model
by: Li Cui, et al.
Published: (2023-05-01)

MORPHOMETRIC DIMENSIONS OF HUMAN EAR OSSICLES OF MALES
by: Shubhpreet Sodhi, et al.
Published: (2017-03-01)

Intratympanic dexamethasone microcrystal-loaded porous PLGA microspheres containing lipoic acid for combined delivery to the inner ear
by: Peili Zhang, et al.
Published: (2025-07-01)

Comparison of the Pathway to the Inner Ear Between Postauricular and Intramuscular Injection of Dexamethasone in Guinea Pigs
by: Aiping Chen, et al.
Published: (2022-03-01)

Influence of Dexamethasone on the Plasma and Milk Disposition Kinetics of Danofloxacin in Lactating Sheep
by: Kamil Uney, et al.
Published: (2025-03-01)

Multivalent Ions as Reactive Crosslinkers for Biopolymers—A Review
by: Florian Wurm, et al.
Published: (2020-04-01)

Pharmacokinetic Study of Intranasal Dexamethasone and Methylprednisolone Compared with Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study in Healthy Volunteers
by: Graciela Cárdenas, et al.
Published: (2022-12-01)

Topical Sustained-Release Dexamethasone-Loaded Chitosan Nanoparticles: Assessment of Drug Delivery Efficiency in a Rabbit Model of Endotoxin-Induced Uveitis
by: Musaed Alkholief, et al.
Published: (2023-09-01)

EVA implants for controlled drug delivery to the inner ear
by: Y. Bedulho das Lages, et al.
Published: (2024-12-01)

Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund’s adjuvant induced arthritis rats
by: Sajeev Kumar Babasahib, et al.
Published: (2022-12-01)

A hydrogel based quasi-stationary test system for in vitro dexamethasone release studies for middle ear drug delivery systems
by: Eickner Thomas, et al.
Published: (2021-10-01)

Anesthesia protocol for ear surgery in Wistar rats (animal research)
by: Abhijeet Bhatia, et al.
Published: (2022-04-01)

Clinical trials in otology: Examining trends and framework for prioritization
by: Jake Altshuler, et al.
Published: (2021-04-01)

TMTC4 is a hair cell–specific human deafness gene
by: Jiang Li, et al.
Published: (2023-12-01)

Noise induces Ca2+ signaling waves and Chop/S-Xbp1 expression in the hearing cochlea
by: Yesai Park, et al.
Published: (2025-01-01)