Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection

ABSTRACT Disulfide exchange is underexplored as a mechanism influencing HIV-1 entry. Prior studies demonstrated that redox enzyme inhibition can prevent HIV-1 infection but with limited mechanistic explanation. We hypothesize that ligand-driven rearrangement (“conformational activation”) enables enz...

Full description

Bibliographic Details
Published in:	Journal of Virology
Main Authors:	Charles G. Ang, Nadia L. Hyatt, Giang Le Minh, Monisha Gupta, Manali Kadam, Philip J. Hogg, Amos B. Smith, Irwin M. Chaiken
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-03-01
Subjects:	HIV-1 Env thioredoxins allosteric disulfides virus entry entry inhibitors
Online Access:	https://journals.asm.org/doi/10.1128/jvi.01471-24

Similar Items

Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry
by: Charles Gotuaco Ang, et al.
Published: (2021-06-01)

Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection
by: Stantchev Tzanko S, et al.
Published: (2012-12-01)

Multiple Disulfide-Bonded States of Native Proteins: Estimate of Number Using Probabilities of Disulfide Bond Formation
by: Philip J. Hogg
Published: (2020-12-01)

Protein Disulfide Isomerase A4 Is Involved in Genome Uncoating during Human Astrovirus Cell Entry
by: Nayeli Aguilar-Hernández, et al.
Published: (2020-12-01)

Reduction of leucocyte cell surface disulfide bonds during immune activation is dynamic as revealed by a quantitative proteomics workflow (SH-IQ)
by: Monika Stegmann, et al.
Published: (2018-09-01)

Disulfide stress and its role in cardiovascular diseases
by: Shaoju Qian, et al.
Published: (2024-09-01)

Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage
by: Marianne Boutin, et al.
Published: (2023-05-01)

A Fluorescent Probe to Detect Quick Disulfide Reductase Activity in Bacteria
by: Ying Zhao, et al.
Published: (2022-02-01)

Allosteric Disulfide Bridges in Integrins: The Molecular Switches of Redox Regulation of Integrin-Mediated Cell Functions
by: Johannes A. Eble
Published: (2025-08-01)

Overexpression of the Interferon-Inducible Isoform 4 of <i>NCOA7</i> Dissects the Entry Route of Enveloped Viruses and Demonstrates that HIV Enters Cells via Fusion at the Plasma Membrane
by: Nikolas Herold
Published: (2019-01-01)

Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies
by: Jennie M. Hutchinson, et al.
Published: (2019-05-01)

Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage
by: Lifei Yang, et al.
Published: (2018-07-01)

Crystallographic Studies Evidencing the High Energy Tolerance to Disrupting the Interface Disulfide Bond of Thioredoxin 1 from White Leg Shrimp Litopenaeus vannamei
by: Adam A. Campos-Acevedo, et al.
Published: (2014-12-01)

Determinants and Mechanisms of the Low Fusogenicity and High Dependence on Endosomal Entry of Omicron Subvariants
by: Panke Qu, et al.
Published: (2023-02-01)

TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone
by: Attila Andor, et al.
Published: (2023-11-01)

Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination
by: Rebecca Heß, et al.
Published: (2019-02-01)

Chemical Synthesis of the Sec-To-Cys Homologue of Human Selenoprotein F and Elucidation of Its Disulfide-pairing Mode
by: Peisi Liao, et al.
Published: (2021-07-01)

Thioredoxin‐interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress
by: Samuel Lee, et al.
Published: (2014-05-01)

Epidemiological analysis of syphilis surveillance among entry-exit population at Shanghai Port, China from 2014 to 2022
by: Quan Jin, et al.
Published: (2023-08-01)

Blockchain and its application to accounting
by: Eladio Pascual Pedreño, et al.
Published: (2021-06-01)

A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway
by: Shufeng Liu, et al.
Published: (2015-11-01)

Study on Water Entry of a 3D Torpedo Based on the Improved Smoothed Particle Hydrodynamics Method
by: Xiaowei Cai, et al.
Published: (2024-05-01)

Env diversity-dependent protection of the attenuated equine infectious anaemia virus vaccine
by: Yuezhi Lin, et al.
Published: (2020-01-01)

A Virus Genetic System to Analyze the Fusogenicity of Human Cytomegalovirus Glycoprotein B Variants
by: Xuan Zhou, et al.
Published: (2023-04-01)

The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site
by: Jérémie Prévost, et al.
Published: (2020-06-01)

Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein
by: Shibo Jiang, et al.
Published: (2013-01-01)

The Winner Curse and Social Inefficiency: Double Whammy of R&D Tournament
by: Arijit Mukherjee, et al.
Published: (2011-11-01)

Genome-Wide Characterization of Endogenous Retroviruses in Bombyx mori Reveals the Relatives and Activity of env Genes
by: Min Feng, et al.
Published: (2018-08-01)

Introduction of a More Glutaredoxin-like Active Site to PDI Results in Competition between Protein Substrate and Glutathione Binding
by: Mirva J. Saaranen, et al.
Published: (2022-09-01)

HIV-1 Env Does Not Enable the Development of Protective Broadly Neutralizing Antibodies in an Experimental Autoimmune Encephalomyelitis Mouse Model
by: Gabriel Siracusano, et al.
Published: (2021-11-01)

Review of Re-entry Guidance Methods Based on Trajectory Generation
by: Reza Esmaelzadeh, et al.
Published: (2022-02-01)

Galectin-1 Modulates the Fusogenic Activity of Placental Endogenous Retroviral Envelopes
by: Caroline Toudic, et al.
Published: (2023-12-01)

Investigating the expression of HERV-K env, np9, gag, and rec in bladder cancers
by: Fariba Rafiei, et al.
Published: (2025-06-01)

Analysing the HERV-K env, np9, rec and gag expression in cervical tissues
by: S. Tavakolian, et al.
Published: (2021-11-01)

A Replication-Competent HIV Clone Carrying GFP-Env Reveals Rapid Env Recycling at the HIV-1 T Cell Virological Synapse
by: Lili Wang, et al.
Published: (2021-12-01)

Three-stage entry game: The strategic effects of advertising
by: Kuzmanović Marija, et al.
Published: (2011-01-01)

Determinants of Net Entry and Exit in Iran’s Manufacturing Industries
by: Mohammad Bagher Beheshty, et al.
Published: (2009-03-01)

Ideal entry point and direction of retrograde intramedullary nailing of the tibia
by: Min He, et al.
Published: (2023-06-01)

Experimental Research on the Influences of Head Shape and Surface Properties on the Water Entry Cavity
by: Yao Shi, et al.
Published: (2022-10-01)

The Spanish company in China: Entry forms and barriers to internationalization
by: Àngels Niñerola, et al.
Published: (2016-02-01)