| Summary: | <i>Pueraria lobata</i> (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that <i>P. lobata</i> plays an essential role in controlling cytokines. However, the exact mechanism of the inflammation response is still unknown. In this study, we observed the uptake of <i>P. lobata</i>-derived exosomes (Exos) in isolated mouse macrophages. Our results show that <i>P. lobata</i>-derived Exos shift M1 macrophages toward the M2. These data present that <i>P. lobata</i> and puerarin might exert and enhance anti-inflammatory effects through the activation of exosomes and shifts in macrophage polarization, providing strong evidence for the application of <i>P. lobata</i> as novel an anti-inflammatory therapeutic biomaterial.
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