Edible <i>Pueraria lobata</i>-Derived Exosomes Promote M2 Macrophage Polarization
<i>Pueraria lobata</i> (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that <i>P. lobata</i> plays an essential role in controlling cytokines. However, the exact mechanism of the inflammat...
| 出版年: | Molecules |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
MDPI AG
2022-11-01
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| 主題: | |
| オンライン･アクセス: | https://www.mdpi.com/1420-3049/27/23/8184 |
| _version_ | 1850033550306312192 |
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| author | Jiaqi Wu Xiaoyu Ma Yu Lu Tao Zhang Zuoqin Du Jin Xu Jingcan You Ni Chen Xin Deng Jianbo Wu |
| author_facet | Jiaqi Wu Xiaoyu Ma Yu Lu Tao Zhang Zuoqin Du Jin Xu Jingcan You Ni Chen Xin Deng Jianbo Wu |
| author_sort | Jiaqi Wu |
| collection | DOAJ |
| container_title | Molecules |
| description | <i>Pueraria lobata</i> (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that <i>P. lobata</i> plays an essential role in controlling cytokines. However, the exact mechanism of the inflammation response is still unknown. In this study, we observed the uptake of <i>P. lobata</i>-derived exosomes (Exos) in isolated mouse macrophages. Our results show that <i>P. lobata</i>-derived Exos shift M1 macrophages toward the M2. These data present that <i>P. lobata</i> and puerarin might exert and enhance anti-inflammatory effects through the activation of exosomes and shifts in macrophage polarization, providing strong evidence for the application of <i>P. lobata</i> as novel an anti-inflammatory therapeutic biomaterial. |
| format | Article |
| id | doaj-art-af4e32ecc80a4e469a2cd3fe40dbc86a |
| institution | Directory of Open Access Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-af4e32ecc80a4e469a2cd3fe40dbc86a2025-08-20T00:35:08ZengMDPI AGMolecules1420-30492022-11-012723818410.3390/molecules27238184Edible <i>Pueraria lobata</i>-Derived Exosomes Promote M2 Macrophage PolarizationJiaqi Wu0Xiaoyu Ma1Yu Lu2Tao Zhang3Zuoqin Du4Jin Xu5Jingcan You6Ni Chen7Xin Deng8Jianbo Wu9Drug Discovery Research Center, Southwest Medical University, Luzhou 646000, ChinaDrug Discovery Research Center, Southwest Medical University, Luzhou 646000, ChinaDrug Discovery Research Center, Southwest Medical University, Luzhou 646000, ChinaDrug Discovery Research Center, Southwest Medical University, Luzhou 646000, ChinaDrug Discovery Research Center, Southwest Medical University, Luzhou 646000, ChinaDrug Discovery Research Center, Southwest Medical University, Luzhou 646000, ChinaDrug Discovery Research Center, Southwest Medical University, Luzhou 646000, ChinaDrug Discovery Research Center, Southwest Medical University, Luzhou 646000, ChinaDrug Discovery Research Center, Southwest Medical University, Luzhou 646000, ChinaDrug Discovery Research Center, Southwest Medical University, Luzhou 646000, China<i>Pueraria lobata</i> (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that <i>P. lobata</i> plays an essential role in controlling cytokines. However, the exact mechanism of the inflammation response is still unknown. In this study, we observed the uptake of <i>P. lobata</i>-derived exosomes (Exos) in isolated mouse macrophages. Our results show that <i>P. lobata</i>-derived Exos shift M1 macrophages toward the M2. These data present that <i>P. lobata</i> and puerarin might exert and enhance anti-inflammatory effects through the activation of exosomes and shifts in macrophage polarization, providing strong evidence for the application of <i>P. lobata</i> as novel an anti-inflammatory therapeutic biomaterial.https://www.mdpi.com/1420-3049/27/23/8184plant<i>Pueraria lobata</i>exosomemacrophagepolarization |
| spellingShingle | Jiaqi Wu Xiaoyu Ma Yu Lu Tao Zhang Zuoqin Du Jin Xu Jingcan You Ni Chen Xin Deng Jianbo Wu Edible <i>Pueraria lobata</i>-Derived Exosomes Promote M2 Macrophage Polarization plant <i>Pueraria lobata</i> exosome macrophage polarization |
| title | Edible <i>Pueraria lobata</i>-Derived Exosomes Promote M2 Macrophage Polarization |
| title_full | Edible <i>Pueraria lobata</i>-Derived Exosomes Promote M2 Macrophage Polarization |
| title_fullStr | Edible <i>Pueraria lobata</i>-Derived Exosomes Promote M2 Macrophage Polarization |
| title_full_unstemmed | Edible <i>Pueraria lobata</i>-Derived Exosomes Promote M2 Macrophage Polarization |
| title_short | Edible <i>Pueraria lobata</i>-Derived Exosomes Promote M2 Macrophage Polarization |
| title_sort | edible i pueraria lobata i derived exosomes promote m2 macrophage polarization |
| topic | plant <i>Pueraria lobata</i> exosome macrophage polarization |
| url | https://www.mdpi.com/1420-3049/27/23/8184 |
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