Parasitic antigens alter macrophage polarization during Schistosoma japonicum infection in mice

Abstract Background Schistosome eggs are trapped in host liver and elicit severe hepatic granulomatous inflammation, which can lead to periportal fibrosis, portal hypertension, hemorrhage, or even death in the host. It was reported that the macrophage plays an important role in host immune responses...

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Bibliographic Details
Published in:Parasites & Vectors
Main Authors: Jifeng Zhu, Zhipeng Xu, Xiaojun Chen, Sha Zhou, Weiwei Zhang, Ying Chi, Wei Li, Xian Song, Feng Liu, Chuan Su
Format: Article
Language:English
Published: BMC 2014-03-01
Subjects:
Schistosoma japonicum
Liver fibrosis
Macrophage polarization
Schistosomal antigen
Online Access:https://doi.org/10.1186/1756-3305-7-122

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