Determining the Bordetella LPS structural features that influence TLR4 downstream signaling

Upon recognizing bacterial lipopolysaccharide (LPS), human TLR4 initiates two distinct signaling pathways: the MyD88 pathway from the cell surface or the TRIF pathway following endocytosis. While the first is associated with strong pro-inflammatory responses, the latter is linked to dendritic cell m...

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Bibliographic Details
Published in:	Frontiers in Microbiology
Main Authors:	Kiruthika Manivannan, Yasmine Fathy Mohamed, Rachel C. Fernandez
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Subjects:	Bordetella LPS TLR4 MyD88 NFκB TRIF
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1540534/full

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