Non-invasive Sampling for Assessment of Oxidative Stress and Pro-inflammatory Cytokine Levels in Beta-Thalassaemia Major Patients
Background: Beta-thalassaemia (β-thalassaemia) major patients are severely anaemic and require life-long blood transfusions for survival. These patients require iron-chelation therapy as a result of iron overload due to the monthly blood transfusions. The iron over load can cause oxidative damage an...
| Published in: | Romanian Journal of Laboratory Medicine |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-03-01
|
| Subjects: | |
| Online Access: | https://doi.org/10.1515/rrlm-2016-0010 |
| _version_ | 1852817692101181440 |
|---|---|
| author | Rahim Mohd. Rashdan Abd. Tan Jin Ai Mary Anne Mani Ravishankar Ram Kuppusamy Umah Rani |
| author_facet | Rahim Mohd. Rashdan Abd. Tan Jin Ai Mary Anne Mani Ravishankar Ram Kuppusamy Umah Rani |
| author_sort | Rahim Mohd. Rashdan Abd. |
| collection | DOAJ |
| container_title | Romanian Journal of Laboratory Medicine |
| description | Background: Beta-thalassaemia (β-thalassaemia) major patients are severely anaemic and require life-long blood transfusions for survival. These patients require iron-chelation therapy as a result of iron overload due to the monthly blood transfusions. The iron over load can cause oxidative damage and pro-inflammation and therefore, hasten mortality. Thus, regular monitoring of the oxidative stress and pro-inflammation status may be useful in these patients. |
| format | Article |
| id | doaj-art-b2ca91c665f0415ba04896bfbaee2e98 |
| institution | Directory of Open Access Journals |
| issn | 2284-5623 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Sciendo |
| record_format | Article |
| spelling | doaj-art-b2ca91c665f0415ba04896bfbaee2e982025-08-19T20:33:32ZengSciendoRomanian Journal of Laboratory Medicine2284-56232016-03-01241839210.1515/rrlm-2016-0010rrlm-2016-0010Non-invasive Sampling for Assessment of Oxidative Stress and Pro-inflammatory Cytokine Levels in Beta-Thalassaemia Major PatientsRahim Mohd. Rashdan Abd.0Tan Jin Ai Mary Anne1Mani Ravishankar Ram2Kuppusamy Umah Rani3Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaBackground: Beta-thalassaemia (β-thalassaemia) major patients are severely anaemic and require life-long blood transfusions for survival. These patients require iron-chelation therapy as a result of iron overload due to the monthly blood transfusions. The iron over load can cause oxidative damage and pro-inflammation and therefore, hasten mortality. Thus, regular monitoring of the oxidative stress and pro-inflammation status may be useful in these patients.https://doi.org/10.1515/rrlm-2016-0010β-thalassaemia majorsalivaoxidative stressbiochemical analysis |
| spellingShingle | Rahim Mohd. Rashdan Abd. Tan Jin Ai Mary Anne Mani Ravishankar Ram Kuppusamy Umah Rani Non-invasive Sampling for Assessment of Oxidative Stress and Pro-inflammatory Cytokine Levels in Beta-Thalassaemia Major Patients β-thalassaemia major saliva oxidative stress biochemical analysis |
| title | Non-invasive Sampling for Assessment of Oxidative Stress and Pro-inflammatory Cytokine Levels in Beta-Thalassaemia Major Patients |
| title_full | Non-invasive Sampling for Assessment of Oxidative Stress and Pro-inflammatory Cytokine Levels in Beta-Thalassaemia Major Patients |
| title_fullStr | Non-invasive Sampling for Assessment of Oxidative Stress and Pro-inflammatory Cytokine Levels in Beta-Thalassaemia Major Patients |
| title_full_unstemmed | Non-invasive Sampling for Assessment of Oxidative Stress and Pro-inflammatory Cytokine Levels in Beta-Thalassaemia Major Patients |
| title_short | Non-invasive Sampling for Assessment of Oxidative Stress and Pro-inflammatory Cytokine Levels in Beta-Thalassaemia Major Patients |
| title_sort | non invasive sampling for assessment of oxidative stress and pro inflammatory cytokine levels in beta thalassaemia major patients |
| topic | β-thalassaemia major saliva oxidative stress biochemical analysis |
| url | https://doi.org/10.1515/rrlm-2016-0010 |
| work_keys_str_mv | AT rahimmohdrashdanabd noninvasivesamplingforassessmentofoxidativestressandproinflammatorycytokinelevelsinbetathalassaemiamajorpatients AT tanjinaimaryanne noninvasivesamplingforassessmentofoxidativestressandproinflammatorycytokinelevelsinbetathalassaemiamajorpatients AT maniravishankarram noninvasivesamplingforassessmentofoxidativestressandproinflammatorycytokinelevelsinbetathalassaemiamajorpatients AT kuppusamyumahrani noninvasivesamplingforassessmentofoxidativestressandproinflammatorycytokinelevelsinbetathalassaemiamajorpatients |