Data describing the effects of depletion of Myoparr, myogenin, Ddx17, and hnRNPK in differentiating C2C12 cells

• Published in: Data in Brief
• Main Authors: Keisuke Hitachi, Kunihiro Tsuchida
• Format: Article
• Language: English
• Published: Elsevier 2019-08-01
• Online Access: http://www.sciencedirect.com/science/article/pii/S2352340919305268

Myoparr is a promoter-associated long non-coding RNA (lncRNA) that is expressed from the promoter region of myogenin gene. Myoparr is essential for the proper differentiation of skeletal muscle cells; it accomplishes this by activating the expression of myogenin and myogenic microRNAs (miRNAs). In this study, we provide the RNA-seq data describing the changes in gene expression induced by knockdown of Myoparr, myogenin, and two Myoparr-binding proteins (Ddx17 and hnRNPK) during skeletal muscle differentiation in C2C12 cells. Raw data files were deposited in Sequence Read Archive in DNA Data Bank of Japan (DDBJ) under the accession number DRA005527. These data are related to the research article “Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation” Hitachi et al., 2019. Keywords: Skeletal muscle differentiation, RNA-binding protein, transcriptional regulation, RNA-seq, RNA splicing