The Diagnosis of Sepsis-Associated Encephalopathy Using Biomarkers: Are We There Yet?

Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that occurs in patients with sepsis in the absence of direct central nervous system infection or other causes of encephalopathy. SAE is common, occurring in up to 70% of patients with sepsis, and is linked to various clinical mani...

Full description

Bibliographic Details
Published in:	Avicenna Journal of Medicine
Main Authors:	Florin Scarlatescu, Ecaterina Scarlatescu, Dana R. Tomescu, Daniela Bartos
Format:	Article
Language:	English
Published:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2025-04-01
Subjects:	encephalopathy sepsis biomarkers diagnosis
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1808060

Similar Items

Research Progress of Biomarkers of Sepsis-Associated Encephalopathy
by: ChengXin Tang, et al.
Published: (2023-01-01)

Sepsis-Associated Encephalopathy (Review)
by: N. B. Beloborodova, et al.
Published: (2018-01-01)

Biomarkers of sepsis associated encephalopathy: a bibliometric and visualized analysis
by: Chuyao Qi, et al.
Published: (2025-06-01)

Recent advances in the pathogenesis, diagnosis, and treatment of sepsis‐associated encephalopathy
by: Rui Wang, et al.
Published: (2024-06-01)

A summary of the current diagnostic methods for, and exploration of the value of microRNAs as biomarkers in, sepsis-associated encephalopathy
by: Zhang Yuechen, et al.
Published: (2023-03-01)

Aspects of the formation of encephalopathy and myocardiopathy in sepsis
by: M. V. Petrova, et al.
Published: (2023-10-01)

Application of magnetic resonance imaging-related techniques in the diagnosis of sepsis-associated encephalopathy: present status and prospect
by: Shuhui Wu, et al.
Published: (2023-05-01)

Chinese emergency expert consensus on the diagnosis and treatment of sepsis-associated encephalopathy in the elderly
by: Wei Gu, et al.
Published: (2025-08-01)

Research on screening key proteins related to the pathogenesis of sepsis associated encephalopathy based on DIA proteomics technology
by: Wu Shuhui, et al.
Published: (2024-12-01)

Reduced phosphatidylcholine and phosphatidylethanolamine levels correlate with inflammatory activation in sepsis-associated encephalopathy
by: Mubing Qin, et al.
Published: (2025-08-01)

Sepsis-associated encephalopathy: not just delirium
by: Fernando Godinho Zampieri, et al.
Published: (2011-01-01)

Diagnostic utility of neurogenic biomarkers in differentiating sepsis with and without associated encephalopathy: a systematic review and meta-analytic approach
by: Xiaofei Lin, et al.
Published: (2025-10-01)

Research progress in the pathogenesis of sepsis-associated encephalopathy
by: Yue Zhou, et al.
Published: (2024-06-01)

Role of serum neuron-specific enolase levels in the early diagnosis and prognosis of sepsis-associated encephalopathy: a systematic review and meta-analysis
by: MengQin Pei, et al.
Published: (2024-02-01)

Immunohistochemical analysis of GFAP expression in the experimental sepsis-associated encephalopathy
by: T. V. Shulyatnikova, et al.
Published: (2021-12-01)

Pharmacological inhibition of the cGAS-STING pathway suppresses microglia pyroptosis in sepsis-associated encephalopathy
by: Qing-quan Zeng, et al.
Published: (2025-07-01)

EEG changes in critically ill patients with sepsis associated encephalopathy and its correlation with morbidity and mortality
by: Tamer A. Helmy, et al.
Published: (2024-12-01)

The Effect of Sepsis Associated Encephalopathy on One-Year Mortality in Patients Aged 65 Years and Over After Discharge: A Retrospective Cohort Study
by: Şükriye Miray KILINÇER BOZGÜL, et al.
Published: (2024-09-01)

Improved prediction of sepsis-associated encephalopathy in intensive care unit sepsis patients with an innovative nomogram tool
by: Jun Jin, et al.
Published: (2024-02-01)

Ultrastructural features of astroglial endosomal system state in sepsis-associated encephalopathy
by: T. V. Shuliatnikova, et al.
Published: (2020-06-01)

Potential Neuroprotective Role of Melatonin in Sepsis-Associated Encephalopathy Due to Its Scavenging and Anti-Oxidative Properties
by: Mariusz Sieminski, et al.
Published: (2023-09-01)

Gut microbiota and sepsis-associated encephalopathy: pathogenesis and precision therapies
by: Na Wei, et al.
Published: (2025-07-01)

Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy
by: Xiaopeng Shi, et al.
Published: (2024-12-01)

The impact of sedation and analgesia scores on prognosis in critically ill sepsis patients with sepsis-associated encephalopathy: a retrospective analysis
by: Weiqin Wei, et al.
Published: (2025-06-01)

Sepsis biomarkers for early diagnosis of bacteremia in emergency department
by: Neval Yurttutan Uyar, et al.
Published: (2023-06-01)

Advancement in biomarker based effective diagnosis of neonatal sepsis
by: Neha Gopal, et al.
Published: (2023-12-01)

Region-specific neuroprotective effects of meldonium pretreatment in two models of sepsis-associated encephalopathy
by: Aleksandra Ružičić, et al.
Published: (2025-04-01)

Investigating the role of aspirin on the mortality risk of sepsis-associated encephalopathy: a retrospective study
by: Fengzhen Huang, et al.
Published: (2025-03-01)

Early acetaminophen use is associated with the reduced mortality risk in patients with sepsis-associated encephalopathy: a retrospective study
by: Fengzhen Huang, et al.
Published: (2025-06-01)

Sepsis‐associated encephalopathy: Autophagy and miRNAs regulate microglial activation
by: Nannan Qin, et al.
Published: (2024-03-01)

Factors contributing to sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis
by: Zhiyang Zhang, et al.
Published: (2024-05-01)

Targeting the gut microbiome in the management of sepsis-associated encephalopathy
by: Brooke Barlow, et al.
Published: (2022-09-01)

Clinical value of serum neuron-specific enolase in sepsis-associated encephalopathy: a systematic review and meta-analysis
by: Meiling Zhi, et al.
Published: (2024-07-01)

Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice
by: Heng Fang, et al.
Published: (2022-06-01)

Predicting outcomes in patients with sepsis-associated encephalopathy using prefrontal functional connectivity analysis
by: Tae Jung Kim, et al.
Published: (2025-05-01)

Biomarkers of Neonatal Sepsis: Where We Are and Where We Are Going
by: Giovanni Boscarino, et al.
Published: (2023-07-01)

Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy
by: Xin Wang, et al.
Published: (2024-06-01)

Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy
by: Yueyang Xin, et al.
Published: (2022-12-01)

The characteristics of the patients of Sepsis-associated encephalopathy (SAE) in Sanglah Central General Hospital's Emergency Room and Intensive Care Unit in the period from February 2019 to February 2022
by: Exaudi Caesario Parulian Sipahutar, et al.
Published: (2022-12-01)

Advancement in biomarker of neonatal sepsis
by: QIANG Yuehua, et al.
Published: (2024-11-01)