Telomeres and telomerase in endometrial cancer and hyperplasia
Introduction The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer. Material and methods Total RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase exp...
| 出版年: | Archives of Medical Science |
|---|---|
| 主要な著者: | , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Termedia Publishing House
2024-03-01
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| 主題: | |
| オンライン･アクセス: | https://www.archivesofmedicalscience.com/Telomeres-and-telomerase-in-endometrial-cancer-and-hyperplasia,186189,0,2.html |
| _version_ | 1850040604376956928 |
|---|---|
| author | Anna Pańczyszyn Ewa Boniewska-Bernacka Karolina Włodarczyk Iwona Wertel Anna Goc |
| author_facet | Anna Pańczyszyn Ewa Boniewska-Bernacka Karolina Włodarczyk Iwona Wertel Anna Goc |
| author_sort | Anna Pańczyszyn |
| collection | DOAJ |
| container_title | Archives of Medical Science |
| description | Introduction
The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer.
Material and methods
Total RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length.
Results
The control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length.
Conclusions
Telomere extension in endometrial cancer is mediated by telomerase, but telomere length may not be an indicator of endometrioid cancer development. |
| format | Article |
| id | doaj-art-b3526c7495a349bcaf5ce9900a252fb5 |
| institution | Directory of Open Access Journals |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| spelling | doaj-art-b3526c7495a349bcaf5ce9900a252fb52025-08-20T00:32:04ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-03-0120268268510.5114/aoms/186189186189Telomeres and telomerase in endometrial cancer and hyperplasiaAnna Pańczyszyn0https://orcid.org/0000-0003-1580-3925Ewa Boniewska-Bernacka1Karolina Włodarczyk2Iwona Wertel3Anna Goc4Institute of Medical Sciences, Department of Biology and Genetics, Faculty of Medicine, University of Opole, Opole, PolandInstitute of Medical Sciences, Department of Biology and Genetics, Faculty of Medicine, University of Opole, Opole, PolandIndependent Laboratory of Cancer Diagnostics and Immunology, Medical University of Lublin, Lublin, PolandIndependent Laboratory of Cancer Diagnostics and Immunology, Medical University of Lublin, Lublin, PolandInstitute of Medical Sciences, Department of Biology and Genetics, Faculty of Medicine, University of Opole, Opole, PolandIntroduction The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer. Material and methods Total RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length. Results The control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length. Conclusions Telomere extension in endometrial cancer is mediated by telomerase, but telomere length may not be an indicator of endometrioid cancer development.https://www.archivesofmedicalscience.com/Telomeres-and-telomerase-in-endometrial-cancer-and-hyperplasia,186189,0,2.htmltelomeresendometrial cancertelomerase |
| spellingShingle | Anna Pańczyszyn Ewa Boniewska-Bernacka Karolina Włodarczyk Iwona Wertel Anna Goc Telomeres and telomerase in endometrial cancer and hyperplasia telomeres endometrial cancer telomerase |
| title | Telomeres and telomerase in endometrial cancer and hyperplasia |
| title_full | Telomeres and telomerase in endometrial cancer and hyperplasia |
| title_fullStr | Telomeres and telomerase in endometrial cancer and hyperplasia |
| title_full_unstemmed | Telomeres and telomerase in endometrial cancer and hyperplasia |
| title_short | Telomeres and telomerase in endometrial cancer and hyperplasia |
| title_sort | telomeres and telomerase in endometrial cancer and hyperplasia |
| topic | telomeres endometrial cancer telomerase |
| url | https://www.archivesofmedicalscience.com/Telomeres-and-telomerase-in-endometrial-cancer-and-hyperplasia,186189,0,2.html |
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