Immediate Early Gene c-fos in the Brain: Focus on Glial Cells

The <i>c-fos</i> gene was first described as a proto-oncogene responsible for the induction of bone tumors. A few decades ago, activation of the protein product c-fos was reported in the brain after seizures and other noxious stimuli. Since then, multiple studies have used c-fos as a bra...

Full description

Bibliographic Details
Published in:	Brain Sciences
Main Authors:	Fernando Cruz-Mendoza, Fernando Jauregui-Huerta, Adriana Aguilar-Delgadillo, Joaquín García-Estrada, Sonia Luquin
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Subjects:	c-fos glial cell astrocytes microglia oligodendrocytes neurons
Online Access:	https://www.mdpi.com/2076-3425/12/6/687

Similar Items

Interplay Between Aging and Glial Cell Dysfunction: Implications for CNS Health
by: Mario García-Domínguez
Published: (2025-09-01)

Editorial: Glial crosstalk in neurological disorders
by: Ikuko Miyazaki, et al.
Published: (2024-11-01)

Glial cell crosstalk in the local microenvironment following spinal cord injury
by: Erliang Li, et al.
Published: (2025-09-01)

Acid-Sensing Ion Channels in Glial Cells
by: Victoria Cegielski, et al.
Published: (2022-01-01)

Glial Populations in the Human Brain Following Ischemic Injury
by: Victoria Mihailova, et al.
Published: (2023-08-01)

Application of optogenetic glial cells to neuron–glial communication
by: Sujin Hyung, et al.
Published: (2023-10-01)

Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease
by: Vishal Chavda, et al.
Published: (2022-01-01)

ATP indirectly stimulates hippocampal CA1 and CA3 pyramidal neurons via the activation of neighboring P2X7 receptor-bearing astrocytes and NG2 glial cells, respectively
by: Ying Zhang, et al.
Published: (2022-07-01)

Editorial: Glial cells in health and disease: impacts on neural circuits and plasticity
by: Shirin Hosseini, et al.
Published: (2025-02-01)

Stress-induced c-fos expression in the medial prefrontal cortex differentially affects the main residing cell phenotypes
by: Adriana Aguilar-Delgadillo, et al.
Published: (2024-10-01)

Neuroprotective and Neurotoxic Effects of Glial-Derived Exosomes
by: Karina Oyarce, et al.
Published: (2022-06-01)

Neuroglia in Neurodegeneration: Exploring Glial Dynamics in Brain Disorders
by: Nawab John Dar, et al.
Published: (2024-12-01)

Impact of non-neuronal cells in Alzheimer’s disease from a single-nucleus profiling perspective
by: Tra-My Vu, et al.
Published: (2023-06-01)

Glial Cells as Therapeutic Approaches in Brain Ischemia-Reperfusion Injury
by: Ivó H. Hernández, et al.
Published: (2021-06-01)

Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
by: Jingwei Zheng, et al.
Published: (2023-08-01)

The contribution of glial cells to Huntington's disease pathogenesis
by: Daniel K. Wilton, et al.
Published: (2020-09-01)

More Than Cell Markers: Understanding Heterogeneous Glial Responses to Implantable Neural Devices
by: Ouzéna Bouadi, et al.
Published: (2021-04-01)

Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression
by: Kalee N. Holloway, et al.
Published: (2023-02-01)

Editorial: Glial heterogeneity: impact on neuronal function and dysfunction
by: Paola Bezzi, et al.
Published: (2023-07-01)

Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset
by: Kalee N. Holloway, et al.
Published: (2023-03-01)

Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation
by: Cecilia Chavarría, et al.
Published: (2022-04-01)

The Role of Glial Cells in the Pathophysiology of Epilepsy
by: Filiz Onat, et al.
Published: (2025-01-01)

Glial regulation of critical period plasticity
by: Jacob Starkey, et al.
Published: (2023-11-01)

Neuroinflammation and iron metabolism after intracerebral hemorrhage: a glial cell perspective
by: Jia-Jun Ju, et al.
Published: (2025-01-01)

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration
by: Devan L. Puhl, et al.
Published: (2020-12-01)

Contribution of Central and Peripheral Glial Cells in the Development and Persistence of Itch: Therapeutic Implication of Glial Modulation
by: Parisa Gazerani
Published: (2023-01-01)

Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage
by: Jose A. Fernández-Albarral, et al.
Published: (2024-01-01)

Embryonic microglia influence developing hypothalamic glial populations
by: Candace M. Marsters, et al.
Published: (2020-05-01)

Glial modulation of synapse development and plasticity: oligodendrocyte precursor cells as a new player in the synaptic quintet
by: Yetunde O. Akinlaja, et al.
Published: (2024-08-01)

Glial Remodeling in the Ventricular–Subventricular Zone and Corpus Callosum Following Hydrocephalus
by: Tania Campos-Ordoñez, et al.
Published: (2025-07-01)

Functions of p38 MAP Kinases in the Central Nervous System
by: Prita R. Asih, et al.
Published: (2020-09-01)

P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation
by: Barbora Salcman, et al.
Published: (2021-09-01)

Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1
by: Anchel González-Barriga, et al.
Published: (2021-05-01)

Editorial: Glial cells: mere passive contributors to brain function?
by: Donaji Chi-Castañeda, et al.
Published: (2024-01-01)

Glial cell changes in the corpus callosum in chronically-starved mice
by: Annelie Zimmermann, et al.
Published: (2023-12-01)

Liver X Receptor Regulation of Glial Cell Functions in the CNS
by: Xiaoyu Song, et al.
Published: (2022-09-01)

Opioid Receptors in Immune and Glial Cells—Implications for Pain Control
by: Halina Machelska, et al.
Published: (2020-03-01)

The Synergistic Roles of Glial Cells and Non-Coding RNAs in the Pathogenesis of Alzheimer’s Disease and Related Dementias (ADRDs)
by: Sydney J. Risen, et al.
Published: (2025-05-01)

Exercise induction at expression immediate early gene (c-Fos, ARC, EGR-1) in the hippocampus: a systematic review
by: Upik Rahmi, et al.
Published: (2024-04-01)

Cell-to-Cell Interactions Mediating Functional Recovery after Stroke
by: Claudia Alia, et al.
Published: (2021-11-01)