Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles

Presynaptic terminals release neurotransmitters spontaneously in a manner that can be regulated by Ca2+. However, the mechanisms underlying this regulation are poorly understood because the inherent stochasticity and low probability of spontaneous fusion events has curtailed their visualization at i...

Full description

Bibliographic Details
Published in:	eLife
Main Authors:	Jeremy Leitz, Ege T Kavalali
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2014-11-01
Subjects:	synaptic vesicle recycling synaptic terminal spontaneous neurotransmitter release
Online Access:	https://elifesciences.org/articles/03658

Similar Items

Synapsins and the Synaptic Vesicle Reserve Pool: Floats or Anchors?
by: Minchuan Zhang, et al.
Published: (2021-03-01)

Synaptic vesicle proteins and active zone plasticity
by: Robert J Kittel, et al.
Published: (2016-04-01)

Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle release and replenishment in a dosage-dependent manner
by: Zhuo Guan, et al.
Published: (2020-04-01)

Sharing vesicles between central presynaptic terminals: implications for synaptic function
by: Kevin Staras, et al.
Published: (2010-06-01)

Synaptic Vesicle Endocytosis in Different Model Systems
by: Quan Gan, et al.
Published: (2018-06-01)

Spatiotemporal dynamics of multi-vesicular release is determined by heterogeneity of release sites within central synapses
by: Dario Maschi, et al.
Published: (2020-02-01)

Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity
by: Frédéric Doussau, et al.
Published: (2017-10-01)

The role of synaptic protein NSF in the development and progression of neurological diseases
by: Jingyue Yang, et al.
Published: (2024-10-01)

Live imaging of synaptic vesicle release and retrieval in dopaminergic neurons
by: Meera Mani, et al.
Published: (2009-06-01)

Astroglial Connexin 43 Regulates Synaptic Vesicle Release at Hippocampal Synapses
by: Giselle Cheung, et al.
Published: (2023-04-01)

Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex
by: Ucheor B Choi, et al.
Published: (2016-06-01)

Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice
by: Tuhin Virmani, et al.
Published: (2005-11-01)

Synaptic Vesicle Glycoprotein 2C: a role in Parkinson’s disease
by: Chu Hua Chang, et al.
Published: (2024-09-01)

Presynaptic nanodomains: a tale of two synapses
by: Lu-Yang eWANG, et al.
Published: (2015-01-01)

A theory of synaptic transmission
by: Bin Wang, et al.
Published: (2021-12-01)

Altered synaptic homeostasis: a key factor in the pathophysiology of depression
by: Bokai Wang, et al.
Published: (2025-02-01)

Membrane bridging by Munc13-1 is crucial for neurotransmitter release
by: Bradley Quade, et al.
Published: (2019-02-01)

Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses
by: Dario Maschi, et al.
Published: (2018-10-01)

Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
by: Francisca Bertin, et al.
Published: (2023-09-01)

Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses
by: Gerardo Malagon, et al.
Published: (2023-05-01)

Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology
by: Xiling Bian, et al.
Published: (2023-12-01)

SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity
by: Unghwi Lee, et al.
Published: (2021-03-01)

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin
by: Ucheor B Choi, et al.
Published: (2018-07-01)

Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming
by: Christian Keine, et al.
Published: (2022-10-01)

Molecular machines regulating the release probability of synaptic vesicles at the active zone.
by: Christoph eKoerber, et al.
Published: (2016-03-01)

The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion
by: Shanshan Wu, et al.
Published: (2023-04-01)

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region
by: Marcial Camacho, et al.
Published: (2021-11-01)

Altered Synaptic Vesicle Release and Ca2+ Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington’s Disease
by: Sidong Chen, et al.
Published: (2018-12-01)

Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster
by: Aelfwin Stone, et al.
Published: (2023-02-01)

Environmental Enrichment Upregulates Striatal Synaptic Vesicle-Associated Proteins and Improves Motor Function
by: Suk-Young Song, et al.
Published: (2018-07-01)

Synaptic vesicle capture by CaV2.2 calcium channels
by: Fiona K. Wong, et al.
Published: (2013-06-01)

A maximum of two readily releasable vesicles per docking site at a cerebellar single active zone synapse
by: Melissa Silva, et al.
Published: (2024-01-01)

Synaptic vesicle release regulates pre-myelinating oligodendrocyte-axon interactions in a neuron subtype-specific manner
by: James R. Gronseth, et al.
Published: (2024-05-01)

Synaptic Vesicle Tethering and the CaV2.2 Distal C-terminal
by: Fiona K Wong, et al.
Published: (2014-03-01)

Synapsin E-domain is essential for α-synuclein function
by: Alexandra Stavsky, et al.
Published: (2024-05-01)

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion
by: Zhuo Guan, et al.
Published: (2017-09-01)

Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis
by: Yi Yu, et al.
Published: (2018-02-01)

Diverse organization of voltage-gated calcium channels at presynaptic active zones
by: Weijia Zhang, et al.
Published: (2022-12-01)

Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes
by: Eric A Prinslow, et al.
Published: (2017-09-01)

Novel pH-Sensitive Lipid Based Exo-Endocytosis Tracers Reveal Fast Intermixing of Synaptic Vesicle Pools
by: Martin Kahms, et al.
Published: (2018-02-01)