Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia
Abstract Background Historically, adults with relapsed-refractory acute lymphoblastic leukemia (ALL) experienced poor outcomes with intensive chemotherapy. This mature analysis explores the benefit of the addition of sequential blinatumomab to low-intensity mini-Hyper-CVD chemotherapy with inotuzuma...
| Published in: | Journal of Hematology & Oncology |
|---|---|
| Main Authors: | Hagop Kantarjian, Fadi G. Haddad, Nitin Jain, Koji Sasaki, Nicholas J. Short, Sanam Loghavi, Rashmi Kanagal-Shamanna, Jeffrey Jorgensen, Issa Khouri, Partow Kebriaei, Yesid Alvarado, Tapan Kadia, Shilpa Paul, Guillermo Garcia-Manero, Bouthaina Dabaja, Musa Yilmaz, Jovitta Jacob, Rebecca Garris, Susan O’Brien, Farhad Ravandi, Elias Jabbour |
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-05-01
|
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-023-01444-2 |
Similar Items
Inotuzumab ozogamicin and blinatumomab sequential therapy for relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia
by: Tomoaki Ueda, et al.
Published: (2022-01-01)
by: Tomoaki Ueda, et al.
Published: (2022-01-01)
Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab
by: Nicholas J. Short, et al.
Published: (2025-05-01)
by: Nicholas J. Short, et al.
Published: (2025-05-01)
The evolution of acute lymphoblastic leukemia research and therapy at MD Anderson over four decades
by: Elias Jabbour, et al.
Published: (2023-03-01)
by: Elias Jabbour, et al.
Published: (2023-03-01)
Successful treatment of two cases with Philadelphia-chromosome positive acute lymphoblastic leukemia who relapsed after allogeneic stem cell transplantation and the treatments with novel immunotherapies and ponatinib
by: Takayoshi Tachibana, et al.
Published: (2024-12-01)
by: Takayoshi Tachibana, et al.
Published: (2024-12-01)
Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions
by: Bachar Samra, et al.
Published: (2020-06-01)
by: Bachar Samra, et al.
Published: (2020-06-01)
Long-Term Follow up of Blinatumomab in Older Patients with B-Cell Acute Lymphoblastic Leukemia
by: Yamini K. Kathari, et al.
Published: (2024-03-01)
by: Yamini K. Kathari, et al.
Published: (2024-03-01)
Complete Remission with Inotuzumab Ozogamicin as Fourth-Line Salvage Therapy in a Child with Relapsed/Refractory Acute Lymphoblastic Leukemia
by: Athanasios Tragiannidis, et al.
Published: (2024-09-01)
by: Athanasios Tragiannidis, et al.
Published: (2024-09-01)
CD58 expression does not impact response to inotuzumab ozogamicin in patients with B‐cell acute lymphoblastic leukemia
by: Rafael Madero‐Marroquin, et al.
Published: (2025-02-01)
by: Rafael Madero‐Marroquin, et al.
Published: (2025-02-01)
Reevaluating Patient Eligibility for Inotuzumab Ozogamicin Based on CD22 Expression: Is Dim Expression Sufficient?
by: Warren Fingrut, et al.
Published: (2020-12-01)
by: Warren Fingrut, et al.
Published: (2020-12-01)
Real‐World Data on Inotuzumab Ozogamicin for Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia: A GRELAL‐Chile Study
by: Marcela Espinoza, et al.
Published: (2025-09-01)
by: Marcela Espinoza, et al.
Published: (2025-09-01)
Anti-CD22 Calicheamicin-Inotuzumab Ozogamicin Combined with Venetoclax + Azacitidine in the Treatment of Mixed-Phenotype Acute Leukemia: A Case Report
by: Kongfei Li, et al.
Published: (2024-09-01)
by: Kongfei Li, et al.
Published: (2024-09-01)
Assessment of clinical immunogenicity of inotuzumab ozogamicin in patients with non-Hodgkin lymphoma and acute lymphoblastic leukemia
by: Darshana Jani, et al.
Published: (2018-02-01)
by: Darshana Jani, et al.
Published: (2018-02-01)
Treatment of Adult Patients with Relapsed/Refractory B-Cell Philadelphia-Negative Acute Lymphoblastic Leukemia
by: Enrico Maffini, et al.
Published: (2019-05-01)
by: Enrico Maffini, et al.
Published: (2019-05-01)
Efficiency of Inotuzumab Ozogamicin in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia in Relation to CD22 Expression
by: Thulasi Raman Ramalingam, et al.
by: Thulasi Raman Ramalingam, et al.
The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute lymphoblastic leukemia
by: Xiaoxia Wu, et al.
Published: (2024-09-01)
by: Xiaoxia Wu, et al.
Published: (2024-09-01)
Preemptive inotuzumab ozogamicin eradicated measurable residual disease in Ph‐negative acute lymphoblastic leukemia relapsed post CD19 CART therapy
by: Si‐Man Huang, et al.
Published: (2023-12-01)
by: Si‐Man Huang, et al.
Published: (2023-12-01)
Inotuzumab Ozogamicin as a Bridge to Stem Cell Transplantation in Relapsed Pediatric BCP‐ALL After Tisagenlecleucel: A Case Series
by: Margo Aertgeerts, et al.
Published: (2025-03-01)
by: Margo Aertgeerts, et al.
Published: (2025-03-01)
A retrospective analysis of inotuzumab ozogamicin usage in adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia
by: Narendra Agrawal, et al.
Published: (2025-09-01)
by: Narendra Agrawal, et al.
Published: (2025-09-01)
P372: DISMAL OUTCOMES OF PATIENTS WITH RELAPSED/REFRACTORY B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA AFTER FAILURE OF BOTH INOTUZUMAB OZOGAMICIN AND BLINATUMOMAB
by: W. Macaron, et al.
Published: (2022-06-01)
by: W. Macaron, et al.
Published: (2022-06-01)
Reduced-dose chemotherapy followed by blinatumomab for newly diagnosed philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia: a propensity-matched comparison with hyper-CVAD
by: Jing Lu, et al.
Published: (2025-02-01)
by: Jing Lu, et al.
Published: (2025-02-01)
P358: HYPER-CVAD WITH BLINATUMOMAB AND INOTUZUMAB OZOGAMICIN FOR PATIENTS WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME-NEGATIVE B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: A PHASE II STUDY
by: Nicholas Short, et al.
Published: (2023-08-01)
by: Nicholas Short, et al.
Published: (2023-08-01)
Ponatinib/blinatumomab for relapsed Philadelphia chromosome-positive leukemia as a bridge to allogeneic transplantation
by: Yasutaka Sadaga, et al.
Published: (2025-12-01)
by: Yasutaka Sadaga, et al.
Published: (2025-12-01)
Liver elastography for risk-assessment of liver toxicity and risk factors for Sinusoidal obstruction syndrome in patients with acute lymphoblastic leukemia receiving inotuzumab ozogamicin
by: Jayastu Senapati, et al.
Published: (2024-08-01)
by: Jayastu Senapati, et al.
Published: (2024-08-01)
Reduced-dose chemotherapy and blinatumomab as induction treatment for newly diagnosed Ph-negative B-cell precursor acute lymphoblastic leukemia: a phase 2 trial
by: Jing Lu, et al.
Published: (2024-09-01)
by: Jing Lu, et al.
Published: (2024-09-01)
S119: COMBINATION OF MINI-HYPER-CVD AND INOTUZUMAB (INO) FOLLOWED BY BLINATUMOMAB (BLINA) CONSOLIDATION IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) ACUTE LYMPHOBLASTIC LEUKEMIA (ALL): A PHASE II TRIAL
by: Fadi Haddad, et al.
Published: (2023-08-01)
by: Fadi Haddad, et al.
Published: (2023-08-01)
BLINATUMOMAB IN THE THERAPY OF ACUTE B-LYMPHOID LEUKEMIA
by: Ugo Testa, et al.
Published: (2024-08-01)
by: Ugo Testa, et al.
Published: (2024-08-01)
Managment of Relapsed/Refractory ALL With Inotuzumab During COVID-19. A Casr Report
by: Martina Di Palma, et al.
Published: (2022-04-01)
by: Martina Di Palma, et al.
Published: (2022-04-01)
Blinatumomab in pediatric B-acute lymphoblastic leukemia
by: Yifang Cheng, et al.
Published: (2025-07-01)
by: Yifang Cheng, et al.
Published: (2025-07-01)
Blinatumomab in the Treatment of Acute Lymphoblastic Leukemia: Russian Multicenter Clinical Trial
by: SN Bondarenko, et al.
Published: (2019-03-01)
by: SN Bondarenko, et al.
Published: (2019-03-01)
P371: HYPER-CVAD WITH SEQUENTIAL BLINATUMOMAB, WITH OR WITHOUT INOTUZUMAB OZOGAMICIN, IN ADULTS WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME-NEGATIVE B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
by: N. Short, et al.
Published: (2022-06-01)
by: N. Short, et al.
Published: (2022-06-01)
Novel outpatient infusion model of blinatumomab: case studies of two patients
by: LI Guijun, et al.
Published: (2025-04-01)
by: LI Guijun, et al.
Published: (2025-04-01)
Frontline Blinatumomab in Older Adults with Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia
by: Sandrine Niyongere, et al.
Published: (2020-06-01)
by: Sandrine Niyongere, et al.
Published: (2020-06-01)
P355: MINI-HYPER-CVD PLUS INOTUZUMAB OZOGAMICIN, WITH OR WITHOUT BLINATUMOMAB, IN OLDER ADULTS WITH NEWLY DIAGNOSED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: UPDATES FROM A PHASE II TRIAL
by: F. Haddad, et al.
Published: (2022-06-01)
by: F. Haddad, et al.
Published: (2022-06-01)
A Case Report on Dysgraphia in a Patient Receiving Blinatumomab: Complex Characters Are Easy to Find in a Handwriting Test
by: Yasuto Yamamoto, et al.
Published: (2022-05-01)
by: Yasuto Yamamoto, et al.
Published: (2022-05-01)
Inotuzumab ozogamicin for the treatment of adult acute lymphoblastic leukemia: past progress, current research and future directions
by: Nicholas J. Short, et al.
Published: (2024-05-01)
by: Nicholas J. Short, et al.
Published: (2024-05-01)
Leukemia Burden Impacts the Efficacy and Toxicity of Blinatumomab in Pediatric B‐Cell Acute Lymphoblastic Leukemia
by: Weiling Yan, et al.
Published: (2025-08-01)
by: Weiling Yan, et al.
Published: (2025-08-01)
Successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinoma
by: Masuho Saburi, et al.
Published: (2024-01-01)
by: Masuho Saburi, et al.
Published: (2024-01-01)
P373: UPDATES FROM A PHASE II TRIAL OF MINI-HYPER-CVD-INOTUZUMAB WITH OR WITHOUT BLINATUMOMAB IN OLDER PATIENTS WITH NEWLY DIAGNOSED PHILADELPHIA CHROMOSOME (PH)-NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA
by: Fadi Haddad, et al.
Published: (2023-08-01)
by: Fadi Haddad, et al.
Published: (2023-08-01)
Blinatumomab as a Curative Therapy Option for Relapsed/Refractory Infant Acute Lymphoblastic Leukemia Post-Hematopoietic Stem Cell Transplantation - Case Report
by: Suleimen Zhumatayev, et al.
Published: (2024-04-01)
by: Suleimen Zhumatayev, et al.
Published: (2024-04-01)
Use of blinatumomab and CAR T-cell therapy in children with relapsed/refractory leukemia: A case series study
by: Songmi Wang, et al.
Published: (2023-01-01)
by: Songmi Wang, et al.
Published: (2023-01-01)
Similar Items
-
Inotuzumab ozogamicin and blinatumomab sequential therapy for relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia
by: Tomoaki Ueda, et al.
Published: (2022-01-01) -
Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab
by: Nicholas J. Short, et al.
Published: (2025-05-01) -
The evolution of acute lymphoblastic leukemia research and therapy at MD Anderson over four decades
by: Elias Jabbour, et al.
Published: (2023-03-01) -
Successful treatment of two cases with Philadelphia-chromosome positive acute lymphoblastic leukemia who relapsed after allogeneic stem cell transplantation and the treatments with novel immunotherapies and ponatinib
by: Takayoshi Tachibana, et al.
Published: (2024-12-01) -
Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions
by: Bachar Samra, et al.
Published: (2020-06-01)
