A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.
Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for variants th...
| 出版年: | PLoS Genetics |
|---|---|
| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Public Library of Science (PLoS)
2011-10-01
|
| オンライン･アクセス: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002333&type=printable |
| _version_ | 1849453181807886336 |
|---|---|
| author | Ida Surakka Aaron Isaacs Lennart C Karssen Pirkka-Pekka P Laurila Rita P S Middelberg Emmi Tikkanen Janina S Ried Claudia Lamina Massimo Mangino Wilmar Igl Jouke-Jan Hottenga Vasiliki Lagou Pim van der Harst Irene Mateo Leach Tõnu Esko Zoltán Kutalik Nicholas W Wainwright Maksim V Struchalin Antti-Pekka Sarin Antti J Kangas Jorma S Viikari Markus Perola Taina Rantanen Ann-Kristin Petersen Pasi Soininen Asa Johansson Nicole Soranzo Andrew C Heath Theodore Papamarkou Inga Prokopenko Anke Tönjes Florian Kronenberg Angela Döring Fernando Rivadeneira Grant W Montgomery John B Whitfield Mika Kähönen Terho Lehtimäki Nelson B Freimer Gonneke Willemsen Eco J C de Geus Aarno Palotie Manj S Sandhu Dawn M Waterworth Andres Metspalu Michael Stumvoll André G Uitterlinden Antti Jula Gerjan Navis Cisca Wijmenga Bruce H R Wolffenbuttel Marja-Riitta Taskinen Mika Ala-Korpela Jaakko Kaprio Kirsten O Kyvik Dorret I Boomsma Nancy L Pedersen Ulf Gyllensten James F Wilson Igor Rudan Harry Campbell Peter P Pramstaller Tim D Spector Jacqueline C M Witteman Johan G Eriksson Veikko Salomaa Ben A Oostra Olli T Raitakari H-Erich Wichmann Christian Gieger Marjo-Riitta Järvelin Nicholas G Martin Albert Hofman Mark I McCarthy Leena Peltonen Cornelia M van Duijn Yurii S Aulchenko Samuli Ripatti ENGAGE Consortium |
| author_facet | Ida Surakka Aaron Isaacs Lennart C Karssen Pirkka-Pekka P Laurila Rita P S Middelberg Emmi Tikkanen Janina S Ried Claudia Lamina Massimo Mangino Wilmar Igl Jouke-Jan Hottenga Vasiliki Lagou Pim van der Harst Irene Mateo Leach Tõnu Esko Zoltán Kutalik Nicholas W Wainwright Maksim V Struchalin Antti-Pekka Sarin Antti J Kangas Jorma S Viikari Markus Perola Taina Rantanen Ann-Kristin Petersen Pasi Soininen Asa Johansson Nicole Soranzo Andrew C Heath Theodore Papamarkou Inga Prokopenko Anke Tönjes Florian Kronenberg Angela Döring Fernando Rivadeneira Grant W Montgomery John B Whitfield Mika Kähönen Terho Lehtimäki Nelson B Freimer Gonneke Willemsen Eco J C de Geus Aarno Palotie Manj S Sandhu Dawn M Waterworth Andres Metspalu Michael Stumvoll André G Uitterlinden Antti Jula Gerjan Navis Cisca Wijmenga Bruce H R Wolffenbuttel Marja-Riitta Taskinen Mika Ala-Korpela Jaakko Kaprio Kirsten O Kyvik Dorret I Boomsma Nancy L Pedersen Ulf Gyllensten James F Wilson Igor Rudan Harry Campbell Peter P Pramstaller Tim D Spector Jacqueline C M Witteman Johan G Eriksson Veikko Salomaa Ben A Oostra Olli T Raitakari H-Erich Wichmann Christian Gieger Marjo-Riitta Järvelin Nicholas G Martin Albert Hofman Mark I McCarthy Leena Peltonen Cornelia M van Duijn Yurii S Aulchenko Samuli Ripatti ENGAGE Consortium |
| author_sort | Ida Surakka |
| collection | DOAJ |
| container_title | PLoS Genetics |
| description | Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32,225). We collected 8 further cohorts (N = 17,102) for replication, and rs6448771 on 4p15 demonstrated genome-wide significant interaction with waist-to-hip-ratio (WHR) on total cholesterol (TC) with a combined P-value of 4.79×10(-9). There were two potential candidate genes in the region, PCDH7 and CCKAR, with differential expression levels for rs6448771 genotypes in adipose tissue. The effect of WHR on TC was strongest for individuals carrying two copies of G allele, for whom a one standard deviation (sd) difference in WHR corresponds to 0.19 sd difference in TC concentration, while for A allele homozygous the difference was 0.12 sd. Our findings may open up possibilities for targeted intervention strategies for people characterized by specific genomic profiles. However, more refined measures of both body-fat distribution and metabolic measures are needed to understand how their joint dynamics are modified by the newly found locus. |
| format | Article |
| id | doaj-art-b59698eee7fa4c7c9f51db92a8ffc2f7 |
| institution | Directory of Open Access Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2011-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| spelling | doaj-art-b59698eee7fa4c7c9f51db92a8ffc2f72025-08-20T03:26:39ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042011-10-01710e100233310.1371/journal.pgen.1002333A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.Ida SurakkaAaron IsaacsLennart C KarssenPirkka-Pekka P LaurilaRita P S MiddelbergEmmi TikkanenJanina S RiedClaudia LaminaMassimo ManginoWilmar IglJouke-Jan HottengaVasiliki LagouPim van der HarstIrene Mateo LeachTõnu EskoZoltán KutalikNicholas W WainwrightMaksim V StruchalinAntti-Pekka SarinAntti J KangasJorma S ViikariMarkus PerolaTaina RantanenAnn-Kristin PetersenPasi SoininenAsa JohanssonNicole SoranzoAndrew C HeathTheodore PapamarkouInga ProkopenkoAnke TönjesFlorian KronenbergAngela DöringFernando RivadeneiraGrant W MontgomeryJohn B WhitfieldMika KähönenTerho LehtimäkiNelson B FreimerGonneke WillemsenEco J C de GeusAarno PalotieManj S SandhuDawn M WaterworthAndres MetspaluMichael StumvollAndré G UitterlindenAntti JulaGerjan NavisCisca WijmengaBruce H R WolffenbuttelMarja-Riitta TaskinenMika Ala-KorpelaJaakko KaprioKirsten O KyvikDorret I BoomsmaNancy L PedersenUlf GyllenstenJames F WilsonIgor RudanHarry CampbellPeter P PramstallerTim D SpectorJacqueline C M WittemanJohan G ErikssonVeikko SalomaaBen A OostraOlli T RaitakariH-Erich WichmannChristian GiegerMarjo-Riitta JärvelinNicholas G MartinAlbert HofmanMark I McCarthyLeena PeltonenCornelia M van DuijnYurii S AulchenkoSamuli RipattiENGAGE ConsortiumRecent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32,225). We collected 8 further cohorts (N = 17,102) for replication, and rs6448771 on 4p15 demonstrated genome-wide significant interaction with waist-to-hip-ratio (WHR) on total cholesterol (TC) with a combined P-value of 4.79×10(-9). There were two potential candidate genes in the region, PCDH7 and CCKAR, with differential expression levels for rs6448771 genotypes in adipose tissue. The effect of WHR on TC was strongest for individuals carrying two copies of G allele, for whom a one standard deviation (sd) difference in WHR corresponds to 0.19 sd difference in TC concentration, while for A allele homozygous the difference was 0.12 sd. Our findings may open up possibilities for targeted intervention strategies for people characterized by specific genomic profiles. However, more refined measures of both body-fat distribution and metabolic measures are needed to understand how their joint dynamics are modified by the newly found locus.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002333&type=printable |
| spellingShingle | Ida Surakka Aaron Isaacs Lennart C Karssen Pirkka-Pekka P Laurila Rita P S Middelberg Emmi Tikkanen Janina S Ried Claudia Lamina Massimo Mangino Wilmar Igl Jouke-Jan Hottenga Vasiliki Lagou Pim van der Harst Irene Mateo Leach Tõnu Esko Zoltán Kutalik Nicholas W Wainwright Maksim V Struchalin Antti-Pekka Sarin Antti J Kangas Jorma S Viikari Markus Perola Taina Rantanen Ann-Kristin Petersen Pasi Soininen Asa Johansson Nicole Soranzo Andrew C Heath Theodore Papamarkou Inga Prokopenko Anke Tönjes Florian Kronenberg Angela Döring Fernando Rivadeneira Grant W Montgomery John B Whitfield Mika Kähönen Terho Lehtimäki Nelson B Freimer Gonneke Willemsen Eco J C de Geus Aarno Palotie Manj S Sandhu Dawn M Waterworth Andres Metspalu Michael Stumvoll André G Uitterlinden Antti Jula Gerjan Navis Cisca Wijmenga Bruce H R Wolffenbuttel Marja-Riitta Taskinen Mika Ala-Korpela Jaakko Kaprio Kirsten O Kyvik Dorret I Boomsma Nancy L Pedersen Ulf Gyllensten James F Wilson Igor Rudan Harry Campbell Peter P Pramstaller Tim D Spector Jacqueline C M Witteman Johan G Eriksson Veikko Salomaa Ben A Oostra Olli T Raitakari H-Erich Wichmann Christian Gieger Marjo-Riitta Järvelin Nicholas G Martin Albert Hofman Mark I McCarthy Leena Peltonen Cornelia M van Duijn Yurii S Aulchenko Samuli Ripatti ENGAGE Consortium A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. |
| title | A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. |
| title_full | A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. |
| title_fullStr | A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. |
| title_full_unstemmed | A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. |
| title_short | A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. |
| title_sort | genome wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist to hip ratio on total cholesterol |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002333&type=printable |
| work_keys_str_mv | AT idasurakka agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT aaronisaacs agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT lennartckarssen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT pirkkapekkaplaurila agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ritapsmiddelberg agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT emmitikkanen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT janinasried agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT claudialamina agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT massimomangino agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT wilmarigl agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT joukejanhottenga agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT vasilikilagou agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT pimvanderharst agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT irenemateoleach agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT tonuesko agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT zoltankutalik agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nicholaswwainwright agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT maksimvstruchalin agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT anttipekkasarin agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT anttijkangas agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT jormasviikari agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT markusperola agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT tainarantanen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT annkristinpetersen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT pasisoininen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT asajohansson agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nicolesoranzo agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT andrewcheath agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT theodorepapamarkou agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ingaprokopenko agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT anketonjes agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT floriankronenberg agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT angeladoring agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT fernandorivadeneira agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT grantwmontgomery agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT johnbwhitfield agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT mikakahonen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT terholehtimaki agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nelsonbfreimer agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT gonnekewillemsen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ecojcdegeus agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT aarnopalotie agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT manjssandhu agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT dawnmwaterworth agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT andresmetspalu agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT michaelstumvoll agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT andreguitterlinden agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT anttijula agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT gerjannavis agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ciscawijmenga agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT brucehrwolffenbuttel agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT marjariittataskinen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT mikaalakorpela agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT jaakkokaprio agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT kirstenokyvik agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT dorretiboomsma agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nancylpedersen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ulfgyllensten agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT jamesfwilson agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT igorrudan agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT harrycampbell agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT peterppramstaller agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT timdspector agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT jacquelinecmwitteman agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT johangeriksson agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT veikkosalomaa agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT benaoostra agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ollitraitakari agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT herichwichmann agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT christiangieger agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT marjoriittajarvelin agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nicholasgmartin agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT alberthofman agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT markimccarthy agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT leenapeltonen agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT corneliamvanduijn agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT yuriisaulchenko agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT samuliripatti agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT engageconsortium agenomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT idasurakka genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT aaronisaacs genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT lennartckarssen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT pirkkapekkaplaurila genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ritapsmiddelberg genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT emmitikkanen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT janinasried genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT claudialamina genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT massimomangino genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT wilmarigl genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT joukejanhottenga genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT vasilikilagou genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT pimvanderharst genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT irenemateoleach genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT tonuesko genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT zoltankutalik genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nicholaswwainwright genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT maksimvstruchalin genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT anttipekkasarin genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT anttijkangas genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT jormasviikari genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT markusperola genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT tainarantanen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT annkristinpetersen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT pasisoininen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT asajohansson genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nicolesoranzo genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT andrewcheath genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT theodorepapamarkou genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ingaprokopenko genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT anketonjes genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT floriankronenberg genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT angeladoring genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT fernandorivadeneira genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT grantwmontgomery genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT johnbwhitfield genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT mikakahonen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT terholehtimaki genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nelsonbfreimer genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT gonnekewillemsen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ecojcdegeus genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT aarnopalotie genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT manjssandhu genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT dawnmwaterworth genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT andresmetspalu genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT michaelstumvoll genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT andreguitterlinden genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT anttijula genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT gerjannavis genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ciscawijmenga genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT brucehrwolffenbuttel genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT marjariittataskinen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT mikaalakorpela genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT jaakkokaprio genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT kirstenokyvik genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT dorretiboomsma genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nancylpedersen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ulfgyllensten genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT jamesfwilson genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT igorrudan genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT harrycampbell genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT peterppramstaller genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT timdspector genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT jacquelinecmwitteman genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT johangeriksson genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT veikkosalomaa genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT benaoostra genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT ollitraitakari genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT herichwichmann genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT christiangieger genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT marjoriittajarvelin genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT nicholasgmartin genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT alberthofman genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT markimccarthy genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT leenapeltonen genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT corneliamvanduijn genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT yuriisaulchenko genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT samuliripatti genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol AT engageconsortium genomewidescreenforinteractionsrevealsanewlocuson4p15modifyingtheeffectofwaisttohipratioontotalcholesterol |