Synergistic Anticancer Effects of Bleomycin and Hesperidin Combination on A549 Non-Small Cell Lung Cancer Cells: Antiproliferative, Apoptotic, Anti-Angiogenic, and Autophagic Insights
<b>Background</b>: This study investigated the combined effects of hesperidin (Hesp), a natural flavonoid, with bleomycin (BL), a commonly used chemotherapy agent, on A549 human lung cancer cells. <b>Methods</b>: Key parameters assessed included cell viability, colony formati...
| Published in: | Pharmaceuticals |
|---|---|
| Main Authors: | Mehmet Kadir Erdogan, Guleser Ozer |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/18/2/254 |
Similar Items
Hesperidin alleviates pulmonary fibrosis by regulating EI24-mediated autophagy
by: Yan Zhang, et al.
Published: (2025-12-01)
by: Yan Zhang, et al.
Published: (2025-12-01)
Combined Hesperidin and Gemcitabine Therapy Modulates Apoptosis and Angiogenesis Pathways in ISHIKAWA Human Endometrial Adenocarcinoma Cells
by: Yasemin Afşin, et al.
Published: (2025-09-01)
by: Yasemin Afşin, et al.
Published: (2025-09-01)
A Comparative Study of Hesperetin, Hesperidin and Hesperidin Glucoside: Antioxidant, Anti-Inflammatory, and Antibacterial Activities In Vitro
by: Sung-Sook Choi, et al.
Published: (2022-08-01)
by: Sung-Sook Choi, et al.
Published: (2022-08-01)
In Vitro Biological Activities of Hesperidin-Related Compounds with Different Solubility
by: Hyo-Jun Lee, et al.
Published: (2024-06-01)
by: Hyo-Jun Lee, et al.
Published: (2024-06-01)
In Vitro Evaluation of Cytotoxic and Pro-Apoptotic Effects of Hesperidin Alone and in Combination with Cisplatin on Human Malignant Melanoma Cell Line (A431)
by: Mehmet Uğur Karabat, et al.
Published: (2025-06-01)
by: Mehmet Uğur Karabat, et al.
Published: (2025-06-01)
Chitosan/Hesperidin Nanoparticles for Sufficient, Compatible, Antioxidant, and Antitumor Drug Delivery Systems
by: May Almukainzi, et al.
Published: (2024-07-01)
by: May Almukainzi, et al.
Published: (2024-07-01)
Hesperidin as a natural Radio-Protector
by: Zhila Ghorbani, et al.
Published: (2015-12-01)
by: Zhila Ghorbani, et al.
Published: (2015-12-01)
The effects of hesperidin on valproic acid-induced reduction in hippocampal neurogenesis through the antioxidant and apoptotic pathways in adult rats
by: Soraya Kaewngam, et al.
Published: (2024-11-01)
by: Soraya Kaewngam, et al.
Published: (2024-11-01)
Bleomycin: A worthy alternative
by: Gursev Sandlas, et al.
Published: (2011-01-01)
by: Gursev Sandlas, et al.
Published: (2011-01-01)
Bleomycin: A worthy alternative
by: Gursev Sandlas, et al.
Published: (2011-01-01)
by: Gursev Sandlas, et al.
Published: (2011-01-01)
Losartan enhances the suppressive effect of pirfenidone on the bleomycin-induced epithelial-mesenchymal transition and oxidative stress in A549 cell line
by: Arian Amirkhosravi, et al.
Published: (2023-08-01)
by: Arian Amirkhosravi, et al.
Published: (2023-08-01)
Investigation of the Effects of Hesperidin on Bisphenol-A Induced Neurotoxicity in Rats
by: Burak Batuhan Laçin, et al.
Published: (2024-04-01)
by: Burak Batuhan Laçin, et al.
Published: (2024-04-01)
Safety of glucosyl hesperidin as a Novel food pursuant to Regulation (EU) 2015/2283
by: EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), et al.
Published: (2024-08-01)
by: EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), et al.
Published: (2024-08-01)
Lovastatin prevents bleomycin-induced DNA damage to HepG2 cells
by: Marjan Nasiri, et al.
Published: (2016-01-01)
by: Marjan Nasiri, et al.
Published: (2016-01-01)
Antitumor Effects of Hesperidin and Cisplatin on Human Osteosarcoma Cells Through Inhibiting Proliferation and Inducing Mitochondrial-Mediated Apoptosis
by: Mehmet Onur Ziyadanoğulları, et al.
Published: (2025-05-01)
by: Mehmet Onur Ziyadanoğulları, et al.
Published: (2025-05-01)
Nintedanib treatment for bleomycin-induced lung injury - First report
by: Dina Rnjak, et al.
Published: (2023-01-01)
by: Dina Rnjak, et al.
Published: (2023-01-01)
Cytoprotective effect and antioxidant activities of hesperidin against cisplatin-induced fibroblast cell
by: Anif Nur Artanti, et al.
Published: (2025-04-01)
by: Anif Nur Artanti, et al.
Published: (2025-04-01)
Bleomycin-Induced Flagellate Dermatitis
by: Esra Turan Erkek, et al.
Published: (2019-05-01)
by: Esra Turan Erkek, et al.
Published: (2019-05-01)
Protective and therapeutic effects of hesperidin in an experimental colitis model
by: Serdal Öğüt, et al.
Published: (2024-11-01)
by: Serdal Öğüt, et al.
Published: (2024-11-01)
Microneedling with topical administration of bleomycin
as a treatment method for plantar warts
by: Michał Smoczok, et al.
Published: (2022-05-01)
by: Michał Smoczok, et al.
Published: (2022-05-01)
Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model
by: Alessia Ricci, et al.
Published: (2022-01-01)
by: Alessia Ricci, et al.
Published: (2022-01-01)
Results of injection sclerotherapy with bleomycin in pediatric lymphatic malformations
by: Vipan Kumar, et al.
Published: (2021-01-01)
by: Vipan Kumar, et al.
Published: (2021-01-01)
Cumulative cardiotoxic effect of bleomycin in experiment
by: A. Gozhenko, et al.
Published: (2021-06-01)
by: A. Gozhenko, et al.
Published: (2021-06-01)
Recovery of pure Hesperidin from Iraqi Sweet Oranges Peel and study the effect in some bacteria
by: Baghdad Science Journal
Published: (2014-06-01)
by: Baghdad Science Journal
Published: (2014-06-01)
New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals
by: Danijela Stanisic, et al.
Published: (2020-10-01)
by: Danijela Stanisic, et al.
Published: (2020-10-01)
Rhoifolin improves bleomycin-induced fibrosis in vivo and cell damage in vitro both related to NRF2/HO-1 pathway
by: Xuehua Wang, et al.
Published: (2025-03-01)
by: Xuehua Wang, et al.
Published: (2025-03-01)
The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis
by: Vats A, et al.
Published: (2023-09-01)
by: Vats A, et al.
Published: (2023-09-01)
Heparan Sulfate and Chondroitin Sulfate Glycosaminoglycans Are Targeted by Bleomycin in Cancer Cells
by: Xiulian Li, et al.
Published: (2017-10-01)
by: Xiulian Li, et al.
Published: (2017-10-01)
Flagellate dermatitis in a patient with testicular germ cell neoplasia on bleomycin
by: Konstantina Mavridou, et al.
Published: (2023-08-01)
by: Konstantina Mavridou, et al.
Published: (2023-08-01)
Evaluating Radioprotective Effect of Hesperidin on Acute Radiation Damage in the Lung Tissue of Rats
by: Rezaeyan A., et al.
Published: (2016-09-01)
by: Rezaeyan A., et al.
Published: (2016-09-01)
Atorvastatin and Hesperidin: A Study into Their Effect on the Liver
by: Tabarek Falih Chichan, et al.
Published: (2025-09-01)
by: Tabarek Falih Chichan, et al.
Published: (2025-09-01)
Modulation of Apoptosis and ER Stress Markers in Hepatocellular Carcinoma Cells by Irinotecan, Hesperidin, and Piperine
by: Serkan Sen, et al.
Published: (2024-11-01)
by: Serkan Sen, et al.
Published: (2024-11-01)
Preparation, Characterization and Stability of Zein Based Nanoparticles Loaded with Hesperidin
by: Fanxing YONG, et al.
Published: (2025-10-01)
by: Fanxing YONG, et al.
Published: (2025-10-01)
The Anticancer Drug Bleomycin Shows Potent Antifungal Activity by Altering Phospholipid Biosynthesis
by: Mona Pokharel, et al.
Published: (2022-10-01)
by: Mona Pokharel, et al.
Published: (2022-10-01)
Current Operating Procedure (COP) for Bleomycin ElectroScleroTherapy (BEST) of low-flow vascular malformations
by: Muir Tobian, et al.
Published: (2024-11-01)
by: Muir Tobian, et al.
Published: (2024-11-01)
The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats
by: Mitra Samareh-Fekri, et al.
Published: (2015-12-01)
by: Mitra Samareh-Fekri, et al.
Published: (2015-12-01)
Flagellate erythema induced by bleomycin toxicity
by: L Appaji, et al.
Published: (2013-01-01)
by: L Appaji, et al.
Published: (2013-01-01)
The Effect of Artesunate on Bleomycin‑Induced Pulmonary Fibrosis
by: Aysun Şengul, et al.
Published: (2025-01-01)
by: Aysun Şengul, et al.
Published: (2025-01-01)
The Effects of Silymarin in Bleomycin-Induced Pulmonary Fibrosis in Mice
by: Safaeian, et al.
Published: (2009-06-01)
by: Safaeian, et al.
Published: (2009-06-01)
Voltammetric Behaviour of Hesperidin at a Composite Graphite Electrode
by: Nimet Numan, et al.
Published: (2020-11-01)
by: Nimet Numan, et al.
Published: (2020-11-01)
Similar Items
-
Hesperidin alleviates pulmonary fibrosis by regulating EI24-mediated autophagy
by: Yan Zhang, et al.
Published: (2025-12-01) -
Combined Hesperidin and Gemcitabine Therapy Modulates Apoptosis and Angiogenesis Pathways in ISHIKAWA Human Endometrial Adenocarcinoma Cells
by: Yasemin Afşin, et al.
Published: (2025-09-01) -
A Comparative Study of Hesperetin, Hesperidin and Hesperidin Glucoside: Antioxidant, Anti-Inflammatory, and Antibacterial Activities In Vitro
by: Sung-Sook Choi, et al.
Published: (2022-08-01) -
In Vitro Biological Activities of Hesperidin-Related Compounds with Different Solubility
by: Hyo-Jun Lee, et al.
Published: (2024-06-01) -
In Vitro Evaluation of Cytotoxic and Pro-Apoptotic Effects of Hesperidin Alone and in Combination with Cisplatin on Human Malignant Melanoma Cell Line (A431)
by: Mehmet Uğur Karabat, et al.
Published: (2025-06-01)
