pH-Sensitive Micelles Based on Double-Hydrophilic Poly(methylacrylic acid)-Poly(ethylene glycol)-Poly(methylacrylic acid) Triblock Copolymer

<p>Abstract</p> <p>pH-sensitive micelles with hydrophilic core and hydrophilic corona were fabricated by self-assembling of triblock copolymer of poly(methylacrylic acid)-poly(ethylene glycol)-poly(methylacrylic acid) at lower solution pH. Transmission electron microscopy and laser...

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Bibliographic Details
Published in:Nanoscale Research Letters
Main Authors: Tao Youhua, Liu Ren, Liu Xiaoya, Chen Mingqing, Yang Cheng, Ni Zhongbin
Format: Article
Language:English
Published: SpringerOpen 2009-01-01
Subjects:
Self-assembly
Micelles
Double-hydrophilic
Triblock copolymers
Online Access:http://dx.doi.org/10.1007/s11671-009-9249-2
Description
Summary:<p>Abstract</p> <p>pH-sensitive micelles with hydrophilic core and hydrophilic corona were fabricated by self-assembling of triblock copolymer of poly(methylacrylic acid)-poly(ethylene glycol)-poly(methylacrylic acid) at lower solution pH. Transmission electron microscopy and laser light scattering studies showed micelles were in nano-scale with narrow size distribution. Solution pH value and the micelles concentration strongly influenced the hydrodynamic radius of the spherical micelles (48&#8211;310 nm). A possible mechanism for the formation of micelles was proposed. The obtained polymeric micelle should be useful for biomedical materials such as carrier of hydrophilic drug.</p>
ISSN:1931-7573
1556-276X

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