Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania.

In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied the MTBC population in Dar es Salaam, Tanzania over a six-ye...

Full description

Bibliographic Details
Published in:	PLoS Pathogens
Main Authors:	Michaela Zwyer, Liliana K Rutaihwa, Etthel Windels, Jerry Hella, Fabrizio Menardo, Mohamed Sasamalo, Gregor Sommer, Lena Schmülling, Sonia Borrell, Miriam Reinhard, Anna Dötsch, Hellen Hiza, Christoph Stritt, George Sikalengo, Lukas Fenner, Bouke C De Jong, Midori Kato-Maeda, Levan Jugheli, Joel D Ernst, Stefan Niemann, Leila Jeljeli, Marie Ballif, Matthias Egger, Niaina Rakotosamimanana, Dorothy Yeboah-Manu, Prince Asare, Bijaya Malla, Horng Yunn Dou, Nicolas Zetola, Robert J Wilkinson, Helen Cox, E Jane Carter, Joachim Gnokoro, Marcel Yotebieng, Eduardo Gotuzzo, Alash'le Abimiku, Anchalee Avihingsanon, Zhi Ming Xu, Jacques Fellay, Damien Portevin, Klaus Reither, Tanja Stadler, Sebastien Gagneux, Daniela Brites
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-04-01
Online Access:	https://doi.org/10.1371/journal.ppat.1010893

Similar Items

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania
by: Hellen Hiza, et al.
Published: (2024-04-01)

Diagnostic accuracy of a sequence-specific Mtb-DNA hybridization assay in urine: a case-control study including subclinical TB cases
by: Yves Tschan, et al.
Published: (2024-06-01)

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania
by: Zhi Ming Xu, et al.
Published: (2025-06-01)

Demography and the dual epidemics of tuberculosis and HIV: Analysis of cross-sectional data from Sub-Saharan Africa.
by: Gambo Aliyu, et al.
Published: (2018-01-01)

Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim [version 1; peer review: 2 approved]
by: Fabrizio Menardo, et al.
Published: (2021-02-01)

Cost comparison of nine-month treatment regimens with 20-month standardized care for the treatment of rifampicin-resistant/multi-drug resistant tuberculosis in Nigeria.
by: Florence O Bada, et al.
Published: (2020-01-01)

The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot
by: Chloé Loiseau, et al.
Published: (2023-04-01)

Experimental dissection of tuberculosis protective immunity: a human perspective
by: Sarah Schmidiger, et al.
Published: (2025-06-01)

Tuberculosis Infection Control Practice among Antiretroviral (ART) Clinics in North Central Nigeria
by: Evaezi Okpokoro, et al.
Published: (2022-01-01)

Prevalence, perception of risk and mycobacterium tuberculosis control practices among healthcare workers in HIV care and treatment centres in North Central Nigeria
by: Evaezi Okpokoro, et al.
Published: (2025-02-01)

Collaborative learning in the digital age: empowering tuberculosis researchers through virtual training
by: Anzaan Dippenaar, et al.
Published: (2024-12-01)

Mycobacterium tuberculosis complex Lineage 1: A neglected cause of tuberculosis.
by: Venus Marie R Rojas, et al.
Published: (2025-10-01)

Corrigendum: Assuring the quality of diagnostic testing: the future is now
by: John Nkengasong, et al.
Published: (2017-07-01)

Assuring the quality of diagnostic testing: The future is now
by: John Nkengasong, et al.
Published: (2016-10-01)

Increase in the number of tuberculosis cases treated following tuberculin skin testing in first-year schoolchildren in Madagascar.
by: Rila Ratovoson, et al.
Published: (2014-01-01)

HIV co-infection is associated with reduced Mycobacterium tuberculosis transmissibility in sub-Saharan Africa.
by: Etthel M Windels, et al.
Published: (2024-05-01)

Complexities and benefits of adopting next-generation sequencing-based tuberculosis diagnostics: a qualitative study among stakeholders in low and high-income countries
by: Elysée Nouvet, et al.
Published: (2023-04-01)

Generating Three-dimensional Human Granulomas in vitro to Study Mycobacterium tuberculosis-host Interaction
by: Ainhoa Arbués, et al.
Published: (2020-11-01)

Tuberculosis in Lemurs and a Fossa at National Zoo, Madagascar, 2022
by: Marni LaFleur, et al.
Published: (2023-12-01)

How do monomorphic bacteria evolve? The Mycobacterium tuberculosis complex and the awkward population genetics of extreme clonality
by: Stritt, Christoph, et al.
Published: (2023-09-01)

Anemia in tuberculosis cases and household controls from Tanzania: Contribution of disease, coinfections, and the role of hepcidin.
by: Jerry Hella, et al.
Published: (2018-01-01)

Prevalence and clinical relevance of helminth co-infections among tuberculosis patients in urban Tanzania.
by: Francis Mhimbira, et al.
Published: (2017-02-01)

Prevalence of pulmonary tuberculosis and HIV infections and risk factors associated to tuberculosis in detained persons in Antananarivo, Madagascar
by: Fanjasoa Rakotomanana, et al.
Published: (2024-04-01)

Bacteria under antibiotic attack: Different strategies for evolutionary adaptation.
by: Etthel M Windels, et al.
Published: (2020-05-01)

Continuous digital cough monitoring during 6-month pulmonary tuberculosis treatment
by: Mihaja Raberahona, et al.
Published: (2025-03-01)

A social network analysis model approach to understand tuberculosis transmission in remote rural Madagascar
by: Christine Pando, et al.
Published: (2023-08-01)

Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages.
by: Damien Portevin, et al.
Published: (2011-03-01)

Towards Accurate Point-of-Care Tests for Tuberculosis in Children
by: Nina Vaezipour, et al.
Published: (2022-03-01)

Low tuberculosis treatment initiation after positive tuberculosis lipoarabinomannan results
by: Tinne Gils, et al.
Published: (2024-07-01)

Assessing the effects of diabetes mellitus on the monocyte-to-lymphocyte ratio and the QuantiFERON-TB gold plus assays for tuberculosis treatment monitoring: a prospective cohort study
by: Paulo Ranaivomanana, et al.
Published: (2025-01-01)

Sustainable clinical laboratory capacity for health in Africa
by: Justine Davies, et al.
Published: (2017-03-01)

Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages
by: Ainhoa Arbués, et al.
Published: (2025-03-01)

Multidrug-resistant tuberculosis surveillance and cascade of care in Madagascar: a five-year (2012–2017) retrospective study
by: Astrid M. Knoblauch, et al.
Published: (2020-06-01)

Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study
by: Kathrin Zürcher, MSc, et al.
Published: (2021-07-01)

C1q and HBHA-specific IL-13 levels as surrogate plasma biomarkers for monitoring tuberculosis treatment efficacy: a cross-sectional cohort study in Paraguay
by: Graciela Russomando, et al.
Published: (2024-03-01)

Linking genetic and phenotypic bedaquiline resistance in Mycobacterium tuberculosis strains from Georgia.
by: Nino Maghradze, et al.
Published: (2025-01-01)

Linking genetic and phenotypic bedaquiline resistance in Mycobacterium tuberculosis strains from Georgia
by: Nino Maghradze, et al.
Published: (2025-01-01)

Bacille Calmette-Guérin Vaccine Strain Modulates the Ontogeny of Both Mycobacterial-Specific and Heterologous T Cell Immunity to Vaccination in Infants
by: Agano Kiravu, et al.
Published: (2019-10-01)

Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis
by: Valerie F. A. March, et al.
Published: (2025-01-01)

Perceptions of tuberculosis and home-based infection screening among families and providers in Madagascar: a qualitative study
by: Voahirana Tantely Annick Andrianantoandro, et al.
Published: (2025-09-01)