Transcription factor-based classification of pituitary adenomas / PitNETs: a comparative analysis and clinical implications across WHO 2004, 2017 and 2022 in 921 cases

Abstract The WHO classifications of 2017 and 2022 recommend the use of pituitary transcription factors PIT-1, T-PIT and SF-1 as well as GATA3 and ERα for histopathological diagnosis. The aim of this study is to demonstrate their diagnostic impact in a large retrospective cohort. 921 PitNETs/PAs diag...

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Bibliographic Details
Published in:	Acta Neuropathologica Communications
Main Authors:	Isabella Nasi-Kordhishti, Mirko Hladik, Kosmas Kandilaris, Felix Behling, Jürgen Honegger, Jens Schittenhelm
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Subjects:	WHO classification Pituitary transcription factors PIT-1 T-PIT SF-1 Pituitary adenoma
Online Access:	https://doi.org/10.1186/s40478-025-02050-8

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