Net Clinical Benefit of Non-vitamin K Antagonist Oral Anticoagulants for Venous Thromboembolism Prophylaxis in Patients With Cancer: A Systematic Review and Trade-Off Analysis From 9 Randomized Controlled Trials

Venous thromboembolism (VTE) is highly prevalent in patients with cancer. Non-vitamin K antagonist oral anticoagulants (NOACs), directly targeting the enzymatic activity of thrombin or factor Xa, have been shown to be as effective as and safer than traditional anticoagulation for VTE prophylaxis in...

Full description

Bibliographic Details
Published in:	Frontiers in Pharmacology
Main Authors:	Yi-Dan Yan, Chi Zhang, Long Shen, Ying-Jie Su, Xiao-Yan Liu, Li-Wei Wang, Zhi-Chun Gu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-06-01
Subjects:	non-vitamin K antagonist oral anticoagulants dabigatran rivaroxaban apixaban edoxaban cancer
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2018.00575/full

Similar Items

Are outpatient anticoagulation management services the wave of the future (again)?
by: Bethany Samuelson Bannow
Published: (2022-05-01)

Drug interactions of non-vitamin K antagonist oral anticoagulants: inside and outside table cells
by: Sergey Nikolaevich Bel'diev, et al.
Published: (2017-11-01)

Drug interactions of non-vitamin K antagonist oral anticoagulants: inside and outside table cells
by: Sergey Nikolaevich Bel'diev, et al.
Published: (2017-11-01)

PHARMACOGENETIC ASPECTS OF NEW ORAL ANTICOAGULANTS APPLICATION
by: A. V. Kryukov, et al.
Published: (2017-07-01)

Direct oral anticoagulants: a guide for daily practice
by: Pierre Fontana, et al.
Published: (2016-02-01)

Non-Vitamin K Antagonist Oral Anticoagulants in Patients with β-Thalassemia
by: Michele Malagù, et al.
Published: (2023-03-01)

Anticoagulation in the early phase of non-valvular atrial fibrillation-related acute ischemic stroke: where do we stand?
by: Luca Masotti, et al.
Published: (2019-01-01)

IMPACT OF NON-VITAMIN K ORAL ANTI-COAGULANTS ON WARFARIN UTILISATION AND NHS BUDGET IN UK
by: Mohammed Aladul, et al.
Published: (2022-09-01)

Effect of systemic anticoagulants on fracture healing in rats tibia
by: Murat Tanrisever, et al.
Published: (2025-10-01)

DRUG INTERACTIONS OF NEW ORAL ANTICOAGULANTS: INSIDE AND OUTSIDE TABLE CELLS
by: S. N. Bel'diev, et al.
Published: (2017-11-01)

Risk Factors of Gastrointestinal Bleeding in Patients Receiving New Oral Anticoagulants
by: Ju Yup Lee
Published: (2018-12-01)

Using Pharmacogenetics of Direct Oral Anticoagulants to Predict Changes in Their Pharmacokinetics and the Risk of Adverse Drug Reactions
by: Natalia A. Shnayder, et al.
Published: (2021-04-01)

New Direct Oral Anticoagulants (DOAC) and Their Use Today
by: Heike Schwarb, et al.
Published: (2016-03-01)

Pharmacology of new oral anticoagulants: mechanism of action, pharmacokinetics, pharmacodynamics
by: Luca Masotti, et al.
Published: (2013-12-01)

Drug-Drug Interactions of Direct Oral Anticoagulants (DOACs): From Pharmacological to Clinical Practice
by: Nicola Ferri, et al.
Published: (2022-05-01)

The treatment of venous thromboembolism with new oral anticoagulants
by: Davide Imberti
Published: (2013-12-01)

Prospects of oral anticoagulant therapy in patients with atrial fibrillation and chronic anemia: a narrative review
by: Tatyana S. Degtyareva, et al.
Published: (2024-12-01)

Is There an Alternative Oral Anticoagulation to Vitamin-K-Antagonists for Patients with Mechanical Aortic Valve Replacement? – A Literature Review
by: Stephen Gerfer, et al.
Published: (2024-05-01)

A novel prothrombin time method to measure all non-vitamin K-dependent oral anticoagulants (NOACs)
by: Tomas L. Lindahl, et al.
Published: (2017-07-01)

EFFICACY AND SAFETY OF THE ORAL ANTICOAGULANTS IN THE MANAGEMENT OF VENOUS THROMBOEMBOLISM: INDIRECT COMPARISON
by: V. I. Petrov, et al.
Published: (2016-12-01)

Clinical outcomes of direct oral anticoagulant off-label dosing in nonvalvular atrial fibrillation
by: M. Jansson, et al.
Published: (2025-09-01)

Safety and efficacy of direct oral anticoagulants in comparison to warfarin in obese patients with atrial fibrillation: A systematic review and meta‐analysis
by: Alla Adelkhanova, et al.
Published: (2024-04-01)

SPECIFIC ANTIDOTES TO NEW ORAL ANTICOAGULANTS
by: O. O. Shakhmatova
Published: (2016-07-01)

Use of direct oral anticoagulants in kidney diseases
by: I.A. Paliienko, et al.
Published: (2025-03-01)

The New Oral Anticoagulants for the Treatment of Venous Thromboembolism: A New Paradigm Shift in Antithrombotic Therapy
by: Taki Galanis, MD, et al.
Published: (2014-12-01)

Direct oral anticoagulants compared to warfarin in long‐term management of cerebral venous thrombosis: A comprehensive meta‐analysis
by: Redoy Ranjan, et al.
Published: (2024-02-01)

Fully automated thromboelastograph TEG 6s to measure anticoagulant effects of direct oral anticoagulants in healthy male volunteers
by: Ramin Artang, et al.
Published: (2019-07-01)

Hospital consumption of direct oral anticoagulants in regions of the Russian Federation in 2017–2022
by: A. V. Matveev, et al.
Published: (2024-01-01)

Direct Oral Anticoagulants (DOACs) are Non-Inferior to Vitamin K Antagonists for Patients Undergoing Transcatheter Aortic Valve Replacement with Indications of Anticoagulation
by: Jia Wang, et al.
Published: (2022-10-01)

Clinically Significant Drug Interactions for Direct Oral Anticoagulants: State of the Art
by: S. R. Gilyarevsky
Published: (2022-07-01)

Direct Oral Anticoagulants for the Prevention and Acute Treatment of Cancer-Associated Thrombosis
by: Attard LM, et al.
Published: (2022-10-01)

Control Of Anticoagulation Therapy in Atrial Fibrillation (COAT-AF Study) in Real Clinical Practice
by: A. A. Zarudsky, et al.
Published: (2020-03-01)

HOW NEW APPROACHES TO THE TREATMENT OF PULMONARY EMBOLISM AFFECT THE OUTCOME OF THE DISEASE?
by: M. Y. Gilyarov, et al.
Published: (2017-12-01)

Efficacy and Safety of Rivaroxaban, Apixaban, and Edoxaban for Nonvalvular Atrial Fibrillation Based on Blood Coagulation Activity and Drug Plasma Concentration: SETtsu and North Osaka Multicenter Direct Oral AntiCoagulant (SET DOAC) Registry
by: Michihiro Suwa, et al.
Published: (2024-10-01)

Novos anticoagulantes orais no tromboembolismo venoso e fibrilhação auricular New oral anticoagulants in the treatment of venous thromboembolism and atrial fibrillation
by: Luís Silvestre, et al.
Published: (2012-03-01)

Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia
by: Evelien Krumb, et al.
Published: (2021-02-01)

Tooth extraction in patients taking nonvitamin K antagonist oral anticoagulants
by: Yoshinari Morimoto, et al.
Published: (2016-03-01)

NEW ORAL ANTICOAGULANTS: FOCUS ON THE SAFETY
by: D. A. Napalkov, et al.
Published: (2015-09-01)

Prerequisites and limitations of the use of oral anticoagulants in pregnant women in real-world clinical practice
by: Kh. A. Zagorodnikova, et al.
Published: (2025-01-01)

Efficacy and safety of new oral anticoagulants compared with warfarin in cardioembolic prophylaxis of patients with non valvular atrial fibrillation. More lights than shadows
by: Luca Masotti, et al.
Published: (2012-10-01)