TAp73 and ΔTAp73 isoforms show cell-type specific distributions and alterations in cancer

Abstract TP73 is a member of the TP53 gene family and produces N- and C-terminal protein isoforms through alternative promoters, alternative translation initiation and alternative splicing. Most notably, p73 protein isoforms may either contain a p53-like transactivation domain (TAp73 isoforms) or la...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Vaclav Hrabal, Michaela Stenckova, Filip Zavadil Kokas, Petr Muller, Rudolf Nenutil, Borivoj Vojtesek, Philip J. Coates
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Subjects:
p73 isoforms
Multiciliated cells
Fallopian tube
Endometrium
Squamous epithelial stem cells
Cervical cancer
Online Access:https://doi.org/10.1038/s41598-024-80927-9

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