Human Cytomegalovirus UL23 Antagonizes the Antiviral Effect of Interferon-γ by Restraining the Expression of Specific IFN-Stimulated Genes
Interferon-γ (IFN-γ) is a critical component of innate immune responses in humans to combat infection by many viruses, including human cytomegalovirus (HCMV). IFN-γ exerts its biological effects by inducing hundreds of IFN-stimulated genes (ISGs). In this study, RNA-seq analyses revealed that HCMV t...
| Published in: | Viruses |
|---|---|
| Main Authors: | Hankun Wang, Weijian Peng, Jialin Wang, Chunling Zhang, Wangchun Zhao, Yanhong Ran, Xiaoping Yang, Jun Chen, Hongjian Li |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/4/1014 |
Similar Items
Human cytomegalovirus UL23 exploits PD-L1 inhibitory signaling pathway to evade T cell-mediated cytotoxicity
by: Qin Yuan, et al.
Published: (2024-07-01)
by: Qin Yuan, et al.
Published: (2024-07-01)
Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection
by: Ayelen Toro, et al.
Published: (2022-09-01)
by: Ayelen Toro, et al.
Published: (2022-09-01)
Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5
by: Hankun Wang, et al.
Published: (2025-12-01)
by: Hankun Wang, et al.
Published: (2025-12-01)
Regulation of Interferon-γ receptor (IFN-γR) expression in macrophages during Mycobacterium tuberculosis infection
by: Kak Gunjan, et al.
Published: (2020-04-01)
by: Kak Gunjan, et al.
Published: (2020-04-01)
Performance of new pp65-IGRA for the quantification of HCMV-specific CD4+ T-cell response in healthy subjects and in solid organ transplant recipients
by: Dalila Mele, et al.
Published: (2025-05-01)
by: Dalila Mele, et al.
Published: (2025-05-01)
Transient Increases in Inflammation and Proapoptotic Potential Are Associated with the HESN Phenotype Observed in a Subgroup of Kenyan Female Sex Workers
by: Marcel Gluchowski, et al.
Published: (2022-02-01)
by: Marcel Gluchowski, et al.
Published: (2022-02-01)
Forms and Methods for Interferon’s Encapsulation
by: Thelvia I. Ramos, et al.
Published: (2021-09-01)
by: Thelvia I. Ramos, et al.
Published: (2021-09-01)
The SUMOylation of Human Cytomegalovirus Capsid Assembly Protein Precursor (UL80.5) Affects Its Interaction with Major Capsid Protein (UL86) and Viral Replication
by: Zhigang Zhang, et al.
Published: (2023-04-01)
by: Zhigang Zhang, et al.
Published: (2023-04-01)
Decreased ex vivo production of interferon-gamma is associated with severity and poor prognosis in patients with lupus
by: Sung Soo Ahn, et al.
Published: (2017-08-01)
by: Sung Soo Ahn, et al.
Published: (2017-08-01)
Antiviral Effects of Avian Interferon-Stimulated Genes
by: Xingchen He, et al.
Published: (2024-10-01)
by: Xingchen He, et al.
Published: (2024-10-01)
AEN Suppresses the Replication of Porcine Epidemic Diarrhea Virus by Inducing the Expression of Type I IFN and ISGs in MARC-145 Cells
by: Miao Luo, et al.
Published: (2023-12-01)
by: Miao Luo, et al.
Published: (2023-12-01)
Role of Interferons in <em>Mycobacterium tuberculosis</em> Infection
by: Gaithrri Shanmuganathan, et al.
Published: (2022-09-01)
by: Gaithrri Shanmuganathan, et al.
Published: (2022-09-01)
Interferon-Gamma Gene Polymorphism in Patients with Tuberculosis
by: biranvand E, et al.
Published: (2011-04-01)
by: biranvand E, et al.
Published: (2011-04-01)
Galectin-9 and Interferon-Gamma Are Released by Natural Killer Cells upon Activation with Interferon-Alpha and Orchestrate the Suppression of Hepatitis C Virus Infection
by: Anna Paola Carreca, et al.
Published: (2022-07-01)
by: Anna Paola Carreca, et al.
Published: (2022-07-01)
IN VITRO SEMI-QUANTITATIVE DETERMINATAION OF HUMAN GAMMA-INTERFERON EXPRESSION BY RT-PCR
by: A. R. Zamani, et al.
Published: (2007-02-01)
by: A. R. Zamani, et al.
Published: (2007-02-01)
Identification and characterization of interferon-γ signaling-based personalized heterogeneity and therapeutic strategies in patients with pancreatic cancer
by: Xu Chen, et al.
Published: (2023-10-01)
by: Xu Chen, et al.
Published: (2023-10-01)
Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts
by: Bettina Groetsch, et al.
Published: (2022-09-01)
by: Bettina Groetsch, et al.
Published: (2022-09-01)
Corrigendum: Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-β Induction
by: Jung-Eun Kim, et al.
Published: (2018-02-01)
by: Jung-Eun Kim, et al.
Published: (2018-02-01)
Use of IFN-Based Biotherapeutics to Harness the Host Against Foot-And-Mouth Disease
by: Gisselle N. Medina, et al.
Published: (2020-08-01)
by: Gisselle N. Medina, et al.
Published: (2020-08-01)
Interferon-gamma FlowSpot assay for the measurement of the T-cell response to cytomegalovirus
by: Qianyu Ye, et al.
Published: (2023-06-01)
by: Qianyu Ye, et al.
Published: (2023-06-01)
Detection of IFN Response of Non-Specific Effects on RNAi
by: Yonggang LIANG, et al.
Published: (2009-01-01)
by: Yonggang LIANG, et al.
Published: (2009-01-01)
Detection of Human cytomegalovirus UL55 Gene and IE/E Protein Expression in Colorectal Cancer Patients in Egypt
by: May Raouf, et al.
Published: (2023-08-01)
by: May Raouf, et al.
Published: (2023-08-01)
Characterization of the transcripts of human cytomegalovirus UL144
by: Sun Zhengrong, et al.
Published: (2011-06-01)
by: Sun Zhengrong, et al.
Published: (2011-06-01)
Expression Profile of Human Cytomegalovirus <i>UL111A</i> cmvIL-10 and LAcmvIL-10 Transcripts in Primary Cells and Cells from Renal Transplant Recipients
by: Giovana W. C. Almeida, et al.
Published: (2025-03-01)
by: Giovana W. C. Almeida, et al.
Published: (2025-03-01)
Recombinant Human Cytomegalovirus Expressing an Analog-Sensitive Kinase pUL97 as Novel Tool for Functional Analyses
by: Nadine Krämer, et al.
Published: (2022-10-01)
by: Nadine Krämer, et al.
Published: (2022-10-01)
Role of hepatitis B virus non-structural protein HBx on HBV replication, interferon signaling, and hepatocarcinogenesis
by: Fei Wang, et al.
Published: (2023-12-01)
by: Fei Wang, et al.
Published: (2023-12-01)
Niveles séricos de factor de necrosis tumoral-α e interferón- γ en pacientes con dengue febril
by: Estela Picaguá, et al.
Published: (2010-12-01)
by: Estela Picaguá, et al.
Published: (2010-12-01)
Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis
by: Tao Yang, et al.
Published: (2022-06-01)
by: Tao Yang, et al.
Published: (2022-06-01)
Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients
by: Baozhen Huang, et al.
Published: (2024-01-01)
by: Baozhen Huang, et al.
Published: (2024-01-01)
Evaluation of the pharmacokinetics of an experimental combined form of IFNα and IFNγ for intranasal use
by: E. V. Kravchenko, et al.
Published: (2024-09-01)
by: E. V. Kravchenko, et al.
Published: (2024-09-01)
Type 1–type 2 interferon imbalance in dry eye disease
by: Trailokyanath Panigrahi, et al.
Published: (2023-01-01)
by: Trailokyanath Panigrahi, et al.
Published: (2023-01-01)
Antiviral effects of interferon-stimulated genes in bats
by: Dan Zhang, et al.
Published: (2023-08-01)
by: Dan Zhang, et al.
Published: (2023-08-01)
Effects of IFN-γ coding plasmid supplementation in the immune response and protection elicited by Trypanosoma cruzi attenuated parasites
by: Cecilia Pérez Brandán, et al.
Published: (2017-11-01)
by: Cecilia Pérez Brandán, et al.
Published: (2017-11-01)
The Profile of Interferon-ɣ and BCG Scar as an Immune Response Reflection in Children with Leprosy
by: Renata Mayangsari, et al.
Published: (2017-01-01)
by: Renata Mayangsari, et al.
Published: (2017-01-01)
CBX3 antagonizes IFNγ/STAT1/PD-L1 axis to modulate colon inflammation and CRC chemosensitivity
by: Yao Xiang, et al.
Published: (2024-04-01)
by: Yao Xiang, et al.
Published: (2024-04-01)
Interferon-γ inhibits group B Streptococcus survival within human endothelial cells
by: Viviane de Oliveira Freitas Lione, et al.
Published: (2014-11-01)
by: Viviane de Oliveira Freitas Lione, et al.
Published: (2014-11-01)
Interaction between human cytomegalovirus UL136 protein and ATP1B1 protein
by: Xin Cui, et al.
Published: (2011-12-01)
by: Xin Cui, et al.
Published: (2011-12-01)
Human Cytomegalovirus Interleukin 10 Homologs: Facing the Immune System
by: Emma Poole, et al.
Published: (2020-06-01)
by: Emma Poole, et al.
Published: (2020-06-01)
Development of an interferon-γ release assay (IGRA) for detection of Brucella abortus and clinical diagnosis of brucellosis
by: Yu Feng, et al.
Published: (2017-12-01)
by: Yu Feng, et al.
Published: (2017-12-01)
Serum Levels of Interleukin-12 and Interferon Gamma in Pediatric Tuberculosis: A Clinico-Microbiological Correlation
by: Neha Gupta, et al.
Published: (2023-05-01)
by: Neha Gupta, et al.
Published: (2023-05-01)
Similar Items
-
Human cytomegalovirus UL23 exploits PD-L1 inhibitory signaling pathway to evade T cell-mediated cytotoxicity
by: Qin Yuan, et al.
Published: (2024-07-01) -
Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection
by: Ayelen Toro, et al.
Published: (2022-09-01) -
Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5
by: Hankun Wang, et al.
Published: (2025-12-01) -
Regulation of Interferon-γ receptor (IFN-γR) expression in macrophages during Mycobacterium tuberculosis infection
by: Kak Gunjan, et al.
Published: (2020-04-01) -
Performance of new pp65-IGRA for the quantification of HCMV-specific CD4+ T-cell response in healthy subjects and in solid organ transplant recipients
by: Dalila Mele, et al.
Published: (2025-05-01)
