Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

• Published in: Einstein (São Paulo)
• Main Authors: Douglas Bastos Neves, Marcela Balbo Rusi, Luiz Gustavo Guedes Diaz, Paolo Salvalaggio
• Format: Article
• Language: English
• Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein
• Subjects: Transplante; Disfunção primária do enxerto/diagnóstico; Transplante de fígado; Seleção do doador; Obtenção de tecidos e órgãos; Fatores de risco
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082016000400567&lng=en&tlng=en
• ISSN: 2317-6385

ABSTRACT Primary graft dysfunction is a multifactorial syndrome with great impact on liver transplantation outcomes. This review article was based on studies published between January 1980 and June 2015 and retrieved from PubMed database using the following search terms: “primary graft dysfunction”, “early allograft dysfunction”, “primary non-function” and “liver transplantation”. Graft dysfunction describes different grades of graft ischemia-reperfusion injury and can manifest as early allograft dysfunction or primary graft non-function, its most severe form. Donor-, surgery- and recipient-related factors have been associated with this syndrome. Primary graft dysfunction definition, diagnostic criteria and risk factors differ between studies.