Polymorphic variants of IL2 and IL4 genes as markers of infertility in case of genital endometriosis

• Published in: RUDN Journal of Medicine
• Main Authors: K S Kublinsky, I D Evtushenko, I O Naslednikova, T A Agarkova
• Format: Article
• Language: English
• Published: Peoples’ Friendship University of Russia (RUDN University) 2012-12-01
• Subjects: эндометриоз; бесплодие; интерлейкин-2; интерлейкин-4; полиморфизм генов цитокинов
• Online Access: http://journals.rudn.ru/medicine/article/view/3678
• ISSN: 2313-0245; 2313-0261

92 patients with genital endometriosis and diagnosed infertility were clinically examined and went through molecular-genetical testing and therapy. Complex therapy included laparoscopic surgery and the course of hormonal therapy (gonadotrophin releasing hormone agonists, combined oral contraceptives). The effect of the therapy increases as increases the possibility of pregnancy in the presence of IL2 gene T-330G TT polymorphism variant and IL4 gene C-590T CC polymorphism variant in the genotype of a woman. The decreased effect of infertility treatment with the diagnosed endometriosis is associated with the presence of the hazardous genotype combination: IL2 gene T-330G GG polymorphism and IL4 gene C-590T TT polymorphism.