OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development

Abstract Background Highly expressed in skeletal muscles, the gene Obscurin (i.e. OBSCN) has 121 non-overlapping exons and codes for some of the largest known mRNAs in the human genome. Furthermore, it plays an essential role in muscle development and function. Mutations in OBSCN are associated with...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Skeletal Muscle
المؤلفون الرئيسيون:	Ali Oghabian, Per Harald Jonson, Swethaa Natraj Gayathri, Mridul Johari, Ella Nippala, David Gomez Andres, Francina Munell, Jessica Camacho Soriano, Maria Angeles Sanchez Duran, Juha Sinisalo, Heli Tolppanen, Johanna Tolva, Peter Hackman, Marco Savarese, Bjarne Udd
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2025-03-01
الموضوعات:	Neuromuscular diseases OBSCN/RNA splicing Exon inclusion Muscle development
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13395-025-00374-6

مواد مشابهة

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