Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques.

HIV-infected infants are at an increased risk of progressing rapidly to AIDS in the first weeks of life. Here, we evaluated immunological and virological parameters in 25 SIV-infected infant rhesus macaques to understand the factors influencing a rapid disease outcome. Infant macaques were infected...

Full description

Bibliographic Details
Published in:	PLoS Pathogens
Main Authors:	Matthew P Wood, Chloe I Jones, Adriana Lippy, Brian G Oliver, Brynn Walund, Katherine A Fancher, Bridget S Fisher, Piper J Wright, James T Fuller, Patience Murapa, Jakob Habib, Maud Mavigner, Ann Chahroudi, D Noah Sather, Deborah H Fuller, Donald L Sodora
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2021-05-01
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009575&type=printable

Similar Items

Combining a rhesus cytomegalovirus/SIV vaccine with a neutralizing antibody to protect against SIV challenges in rhesus macaques
by: Jessica Coppola, et al.
Published: (2025-06-01)

Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques
by: Nichole R. Klatt, et al.
Published: (2021-03-01)

CD8 depletion plus signaling of the non-canonical NF-kB pathway reverses latency in SIV-infected, ART-suppressed rhesus macaques
by: M. Mavigner, et al.
Published: (2019-07-01)

Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques
by: Anna J. Jasinska, et al.
Published: (2025-07-01)

Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques.
by: Emily R Roberts, et al.
Published: (2016-12-01)

Transformation of brain myeloid cell populations by SIV in rhesus macaques revealed by multiomics
by: Xiaoke Xu, et al.
Published: (2025-01-01)

Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques
by: Julien A. Clain, et al.
Published: (2025-02-01)

Neuroinflammatory Profiling in SIV-Infected Chinese-Origin Rhesus Macaques on Antiretroviral Therapy
by: Antonio Solis-Leal, et al.
Published: (2022-01-01)

Correction: Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques.
by: Félicien Moukambi, et al.
Published: (2016-01-01)

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV.
by: Vickie A Marshall, et al.
Published: (2018-07-01)

Clones of SIV-infected cells are present in spleen and lymph nodes in rhesus macaques
by: S.H. Hughes, et al.
Published: (2015-12-01)

Evaluation of Functional NK Cell Responses in Vaccinated and SIV-Infected Rhesus Macaques
by: Diego A. Vargas-Inchaustegui, et al.
Published: (2016-08-01)

SIV Env RhmAbs + N-803 at ART initiation prolongs viral decay without disrupting reservoir establishment in SIV-infected infant macaques.
by: Omotayo Farinre, et al.
Published: (2025-01-01)

Transduction of SIV-specific TCR genes into rhesus macaque CD8+ T cells conveys the ability to suppress SIV replication.
by: Eugene V Barsov, et al.
Published: (2011-01-01)

A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques.
by: Kenta Matsuda, et al.
Published: (2017-08-01)

Isolation and characterization of intestinal epithelial cells from normal and SIV-infected rhesus macaques.
by: Diganta Pan, et al.
Published: (2012-01-01)

SIV/SARS-CoV-2 coinfection in rhesus macaques impacts viral shedding, host immunity, the microbiome, and viral evolution
by: Megan N. Fredericks, et al.
Published: (2025-05-01)

Correction: Transduction of SIV-Specific TCR Genes into Rhesus Macaque CD8+ T Cells Conveys the Ability to Suppress SIV Replication.
by: Eugene V Barsov, et al.
Published: (2018-01-01)

Arsenic trioxide-induced apoptosis contributes to suppression of viral reservoir in SIV-infected rhesus macaques
by: Yizi He, et al.
Published: (2023-10-01)

Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque.
by: Zhao-Wan Yang, et al.
Published: (2016-01-01)

P11-19. Altered mucosal distribution of SIV-specific T cells in Rhesus macaques infected with the live-attenuated Rev-independent SIV
by: Van Rompay K, et al.
Published: (2009-10-01)

Cytotoxic capacity of SIV-specific CD8(+) T cells against primary autologous targets correlates with immune control in SIV-infected rhesus macaques.
by: Daniel Mendoza, et al.
Published: (2013-02-01)

CD3-immunotoxin mediated depletion of T cells in lymphoid tissues of rhesus macaques
by: Lan Wang, et al.
Published: (2023-09-01)

Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques.
by: Sarah J Byrnes, et al.
Published: (2023-03-01)

Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques
by: Hayden N. Brochu, et al.
Published: (2024-11-01)

Mutation in the Disordered Linker Region of Capsid Disrupts Viral Kinetics of a Neuropathogenic SIV in Rhesus Macaques
by: Cheri A. Lee, et al.
Published: (2022-04-01)

Evolutionary distance of amino acid sequence orthologs across macaque subspecies: identifying candidate genes for SIV resistance in Chinese rhesus macaques.
by: Cody T Ross, et al.
Published: (2015-01-01)

Chronic SIV-Induced neuroinflammation disrupts CCR7+ CD4+ T cell immunosurveillance in the rhesus macaque brain
by: Sonny R. Elizaldi, et al.
Published: (2024-05-01)

Longitudinal analysis of rhesus macaque metabolome during acute SIV infection reveals disruption in broad metabolite classes
by: Andrew Hudson, et al.
Published: (2025-03-01)

Viral dissemination and immune activation modulate antiretroviral drug levels in lymph nodes of SIV-infected rhesus macaques
by: Sharat Srinivasula, et al.
Published: (2023-09-01)

SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection
by: Richard C. Crist, et al.
Published: (2025-01-01)

Chronic Binge Alcohol and Ovarian Hormone Loss Dysregulate Circulating Immune Cell SIV Co-Receptor Expression and Mitochondrial Homeostasis in SIV-Infected Rhesus Macaques
by: Patrick M. McTernan, et al.
Published: (2022-07-01)

Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.
by: Bridget S Fisher, et al.
Published: (2018-02-01)

Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques.
by: Daniel R Ram, et al.
Published: (2018-05-01)

Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques
by: John D. Ventura, et al.
Published: (2022-05-01)

PP 4.17 – 00198 Peripheral Blood Biomarkers of Occult Infection in ART-Suppressed, SIV-Infected Rhesus Macaques
by: M. Boudries, et al.
Published: (2022-12-01)

Influence of Naturally Occurring Simian Foamy Viruses (SFVs) on SIV Disease Progression in the Rhesus Macaque (Macaca mulatta) Model
by: Joel Beren, et al.
Published: (2013-06-01)

SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model.
by: Mehdi R M Bidokhti, et al.
Published: (2018-10-01)

Assessment of anti-CD20 antibody pre-treatment for augmentation of CAR-T cell therapy in SIV-infected rhesus macaques
by: Mary S. Pampusch, et al.
Published: (2023-02-01)

<it>In situ </it>detection of Gag-specific CD8<sup>+ </sup>cells in the GI tract of SIV infected Rhesus macaques
by: McElrath M Juliana, et al.
Published: (2010-02-01)