Salivary Biomarkers as a Predictive Factor in Anxiety, Depression, and Stress

Anxiety and depression are highly prevalent mental health disorders often associated with dysregulation of neuroendocrine and immune systems, particularly the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic–adrenal–medullary (SAM) system. Recent research highlights the potential of sal...

Full description

Bibliographic Details
Published in:	Current Issues in Molecular Biology
Main Authors:	Dana Gabriela Budala, Ionut Luchian, Dragos Ioan Virvescu, Teona Tudorici, Vlad Constantin, Zinovia Surlari, Oana Butnaru, Dan Nicolae Bosinceanu, Cosmin Bida, Monica Hancianu
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Subjects:	saliva biomarkers stress anxiety depression cortisol
Online Access:	https://www.mdpi.com/1467-3045/47/7/488

Similar Items

Salivary Biomarkers Identification: Advances in Standard and Emerging Technologies
by: Vlad Constantin, et al.
Published: (2025-04-01)

An Update on the Interdisciplinary Dental Care Approach for Geriatric Diabetic Patients
by: Zenovia Surlari, et al.
Published: (2023-11-01)

Advances and Functional Integration of Hydrogel Composites as Drug Delivery Systems in Contemporary Dentistry
by: Dragos Nicolae Fratila, et al.
Published: (2024-10-01)

AI Efficiency in Dentistry: Comparing Artificial Intelligence Systems with Human Practitioners in Assessing Several Periodontal Parameters
by: Oana-Maria Butnaru, et al.
Published: (2025-03-01)

Creating and Validating a Questionnaire on Dentists’ Perceptions Regarding Periodontics–Prosthodontics Interdisciplinary Clinical Practice
by: Gabriel Rotundu, et al.
Published: (2025-08-01)

Scoping review of the relationship between salivary cortisol and depression
by: Mohammad Ali Saghiri, et al.
Published: (2023-01-01)

The Link between Periodontal Disease and Oral Cancer—A Certainty or a Never-Ending Dilemma?
by: Zinovia Surlari, et al.
Published: (2021-12-01)

Effects of high-intense resistance training on salivary cortisol in trained individuals: a systematic review (Efectos del entrenamiento de resistencia de alta intensidad sobre el cortisol salival en individuos entrenados: una revisión sistemática)
by: Rogério Santos Aguiar, et al.
Published: (2021-07-01)

Association Between Anxiety, Depression, and Salivary Cortisol Levels in Patients with Recurrent Aphthous Stomatitis
by: Cahit Polat, et al.
Published: (2018-09-01)

Salivary cortisol in bruxing and non-bruxing children
by: Silvina Gabriela Cortese, et al.
Published: (2019-01-01)

Short Immobilization in a Sling Does Not Lead to Increased Salivary Cortisol Levels in Pigs
by: Sara Puy, et al.
Published: (2024-09-01)

Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial
by: Praewpat Pachimsawat, et al.
Published: (2024-06-01)

Salivary Biomarkers Associated with Psychological Alterations in Patients with Diabetes: A Systematic Review
by: Guillermo Bargues-Navarro, et al.
Published: (2022-08-01)

Choir versus Solo Singing: Effects on Mood, and Salivary Oxytocin and Cortisol Concentrations
by: T. Moritz Schladt, et al.
Published: (2017-09-01)

Relationship between dental plaque formation and salivary cortisol level in pregnant women
by: Mehdi Shri̇nzad, et al.
Published: (2019-05-01)

Salivary mental stress biomarkers in COVID-19 patients
by: Tanya Deneva, et al.
Published: (2022-11-01)

Salivary cortisol measurements in brachycephalic dog breeds as part of a standardized stress test
by: Elisa Kähler, et al.
Published: (2024-07-01)

Imbalance in the diurnal salivary testosterone/cortisol ratio in men with severe obstructive sleep apnea: an observational study
by: Cristina Mihaela Ghiciuc, et al.

Salivary Cortisol as a Biomarker for Assessing Fear and Anxiety in Patients with Molar–Incisor Hypomineralization
by: Laura-Roxana Contac, et al.
Published: (2025-02-01)

Salivary analysis to unveil the paradigma of stress of domestic horses reared in the wild
by: M. Bazzano, et al.
Published: (2024-05-01)

Evaluation of Salivary Cortisol and Alpha-Amylase Levels in Patients with Geographic Tongue
by: Leila Farhad-Mollashahi, et al.
Published: (2022-03-01)

Salivary Cortisol and Total Antioxidant Capacity (TAC) as Biomarkers of Stress in Dental Medicine Students—A Pilot Study
by: Otilia Bolos, et al.
Published: (2024-11-01)

Evaluation of the Salivary Level of Cortisol in Patients with Oral Lichen Planus: A Meta-Analysis
by: Pia Lopez-Jornet, et al.
Published: (2019-05-01)

The Evaluation of Dental Anxiety in Primary School Children: A Cross-Sectional Study from Romania
by: Ramona Vlad, et al.
Published: (2020-10-01)

The impact of psychological stress on salivary cortisol levels in periodontitis patients: a case-control study
by: Mozaffer Rahim Hingorjo, et al.
Published: (2025-02-01)

Baseline states of mind differentially affected diurnal salivary stress biomarkers: A preliminary study
by: Nattinee Jantaratnotai, et al.
Published: (2022-09-01)

Quality of Life of Complete Denture Wearers—A Comparative Study between Conventional Dentures and Acrylic Dentures with Vitamin B12 Incorporated
by: Dana Gabriela Budală, et al.
Published: (2021-08-01)

Utility of salivary cortisol profile as a predictive biomarker in nurses’ turnover risk: a preliminary study
by: Shinya Yamaguchi, et al.
Published: (2024-01-01)

Salivary cortisol, dehydroepiandrosterone, and chromogranin A levels in patients with gingivitis and periodontitis and a novel biomarker for psychological stress
by: Yeon-Hee Lee, et al.
Published: (2023-04-01)

Effects of Stroking on Salivary Oxytocin and Cortisol in Guide Dogs: Preliminary Results
by: Asahi Ogi, et al.
Published: (2020-04-01)

Daily Fluctuation of Cortisol in the Saliva and Serum of Healthy Persons
by: Nevzeta Ljubijankić, et al.
Published: (2008-05-01)

Determination of cortisol levels in plasma and saliva in women exposed to chronic stress
by: Kršljak Elena, et al.
Published: (2008-01-01)

Evaluation and Comparison of Cortisol Levels in Saliva and Hair among Dental Students
by: Mohammed A. AlSarhan, et al.
Published: (2023-01-01)

MHS status and salivary cortisol concentration in individually housed pigs
by: Nataša SIARD, et al.
Published: (2006-11-01)

Temperature and humidity index (THI) affects salivary cortisol (HC) and dehydroepiandrosterone (DHEA) concentrations in growing bulls following stress generated by performance test procedures
by: Elisa Giaretta, et al.
Published: (2023-07-01)

Association of salivary lactoferrin, Porphyromoras gingivalis and stress hormone levels in patients with periodontitis: a pilot study
by: Desireé Antequera, et al.
Published: (2025-09-01)

Evaluation of salivary cortisol changes and psychological profiles in patients with recurrent aphthous stomatitis
by: Fatemeh Rezaei, et al.
Published: (2017-01-01)

Investigating Non-Pharmacological Stress Reduction Interventions in Pediatric Patients Confirmed with Salivary Cortisol Levels: A Systematic Review
by: Maria Grigoropoulou, et al.
Published: (2023-06-01)

Longitudinal and immediate effect of Kundalini Yoga on salivary levels of cortisol and activity of alpha-amylase and its effect on perceived stress
by: Jocelyn N García-Sesnich, et al.
Published: (2017-01-01)

Comparison of salivary immunoglobulin A and cortisol levels in competitive and non-competitive child male swimmers
by: Bahareh Nazemi Salman, et al.
Published: (2023-03-01)