Bcl-2 proteins: Unraveling the details of a complex and dynamic network
Apoptosis regulation by Bcl-2 proteins is pivotal for mammalians, not only because it is key for development but also because aberrant apoptosis is prerequisite to severe diseases, like cancer. Recently, we quantified interactions within the Bcl-2 protein network in solution and membranes, and addre...
| 出版年: | Molecular & Cellular Oncology |
|---|---|
| 主要な著者: | , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Taylor & Francis Group
2018-01-01
|
| 主題: | |
| オンライン･アクセス: | http://dx.doi.org/10.1080/23723556.2017.1384880 |
| 要約: | Apoptosis regulation by Bcl-2 proteins is pivotal for mammalians, not only because it is key for development but also because aberrant apoptosis is prerequisite to severe diseases, like cancer. Recently, we quantified interactions within the Bcl-2 protein network in solution and membranes, and addressed membrane recruitment, preference of interaction partners and the consequences for Bax activation and inhibition. |
|---|---|
| ISSN: | 2372-3556 |