High-Risk Sarcoidosis: A Focus on Pulmonary, Cardiac, Hepatic and Renal Advanced Diseases, as Well as on Calcium Metabolism Abnormalities

Although sarcoidosis is generally regarded as a benign condition, approximately 20–30% of patients will develop a chronic and progressive disease. Advanced pulmonary fibrotic sarcoidosis and cardiac involvement are the main contributors to sarcoidosis morbidity and mortality, with failure of the liv...

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Bibliographic Details
Published in:Diagnostics
Main Authors: Dominique Israël-Biet, Nicol Bernardinello, Jean Pastré, Claudio Tana, Paolo Spagnolo
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Subjects:
sarcoidosis
high-risk sarcoidosis
sarcoidosis mortality
sarcoidosis morbidity
Online Access:https://www.mdpi.com/2075-4418/14/4/395
Description
Summary:Although sarcoidosis is generally regarded as a benign condition, approximately 20–30% of patients will develop a chronic and progressive disease. Advanced pulmonary fibrotic sarcoidosis and cardiac involvement are the main contributors to sarcoidosis morbidity and mortality, with failure of the liver and/or kidneys representing additional life-threatening situations. In this review, we discuss diagnosis and treatment of each of these complications and highlight how the integration of clinical, pathological and radiological features may help predict the development of such high-risk situations in sarcoid patients.
ISSN:2075-4418

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