Potent neutralizing human monoclonal antibodies protect from Rift Valley fever encephalitis
Rift Valley fever (RVF) is an emerging arboviral disease affecting both humans and livestock. In humans, RVF displays a spectrum of clinical manifestations, including encephalitis. To date, there are no FDA-approved vaccines or therapeutics for human use, although several are in preclinical developm...
| Published in: | JCI Insight |
|---|---|
| Main Authors: | Kaleigh A. Connors, Nathaniel S. Chapman, Cynthia M. McMillen, Ryan M. Hoehl, Jackson J. McGaughey, Zachary D. Frey, Morgan Midgett, Connor Williams, Douglas S. Reed, James E. Crowe Jr., Amy L. Hartman |
| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical investigation
2024-09-01
|
| Subjects: | |
| Online Access: | https://doi.org/10.1172/jci.insight.180151 |
Similar Items
A highly potent human neutralizing antibody prevents vertical transmission of Rift Valley fever virus in a rat model
by: Cynthia M. McMillen, et al.
Published: (2023-07-01)
by: Cynthia M. McMillen, et al.
Published: (2023-07-01)
Neutrophil and macrophage influx into the central nervous system are inflammatory components of lethal Rift Valley fever encephalitis in rats.
by: Joseph R Albe, et al.
Published: (2019-06-01)
by: Joseph R Albe, et al.
Published: (2019-06-01)
Maternal vaccination with live-attenuated Rift Valley fever virus protects offspring via immune transfer
by: Austin T. Hertel, et al.
Published: (2025-07-01)
by: Austin T. Hertel, et al.
Published: (2025-07-01)
Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta.
by: Cynthia M McMillen, et al.
Published: (2022-10-01)
by: Cynthia M McMillen, et al.
Published: (2022-10-01)
The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis.
by: Trevor Griesman, et al.
Published: (2024-06-01)
by: Trevor Griesman, et al.
Published: (2024-06-01)
Inflammatory biomarkers associated with lethal Rift Valley fever encephalitis in the Lewis rat model
by: Amy L. Caroline, et al.
Published: (2016-01-01)
by: Amy L. Caroline, et al.
Published: (2016-01-01)
Oropouche virus infects human trophoblasts and placenta explants
by: Christina J. Megli, et al.
Published: (2025-07-01)
by: Christina J. Megli, et al.
Published: (2025-07-01)
Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses
by: Nathaniel S. Chapman, et al.
Published: (2023-09-01)
by: Nathaniel S. Chapman, et al.
Published: (2023-09-01)
Humoral immunity is sufficient to protect mice against Rift Valley fever encephalitis following percutaneous exposure
by: Karina Mueller Brown, et al.
Published: (2025-07-01)
by: Karina Mueller Brown, et al.
Published: (2025-07-01)
Choice of inbred rat strain impacts lethality and disease course after respiratory infection with Rift Valley Fever virus
by: Jacquelyn M. Bales, et al.
Published: (2012-08-01)
by: Jacquelyn M. Bales, et al.
Published: (2012-08-01)
Rift Valley Fever in Chad
by: David Ringot, et al.
Published: (2004-05-01)
by: David Ringot, et al.
Published: (2004-05-01)
Rift valley Fever virus encephalitis is associated with an ineffective systemic immune response and activated T cell infiltration into the CNS in an immunocompetent mouse model.
by: Kimberly A Dodd, et al.
Published: (2014-06-01)
by: Kimberly A Dodd, et al.
Published: (2014-06-01)
Open Health Tools: Tooling for Interoperable Healthcare
by: Skip McGaughey, et al.
Published: (2008-11-01)
by: Skip McGaughey, et al.
Published: (2008-11-01)
An Overview of Rift Valley Fever Vaccine Development Strategies
by: Paul Kato Kitandwe, et al.
Published: (2022-10-01)
by: Paul Kato Kitandwe, et al.
Published: (2022-10-01)
Current Status of Rift Valley Fever Vaccine Development
by: Bonto Faburay, et al.
Published: (2017-09-01)
by: Bonto Faburay, et al.
Published: (2017-09-01)
Broad spectrum antiviral activity of favipiravir (T-705): protection from highly lethal inhalational Rift Valley Fever.
by: Amy L Caroline, et al.
Published: (2014-04-01)
by: Amy L Caroline, et al.
Published: (2014-04-01)
Monoclonal Antibodies for Rift Valley Fever Virus Nucleocapsid: Application in IgG/IgM ELISA for Sero-Diagnosis
by: Jiansheng Huang, et al.
Published: (2024-07-01)
by: Jiansheng Huang, et al.
Published: (2024-07-01)
Water and the death of ambition in global health, c.1970-1990
by: Christian McMillen
Published: (2020-09-01)
by: Christian McMillen
Published: (2020-09-01)
Seroepidemiology of Rift Valley Fever in Basrah
by: Rahman Kadhum Muhsen
Published: (2012-12-01)
by: Rahman Kadhum Muhsen
Published: (2012-12-01)
Rift Valley Fever in Goats, Cameroon
by: Matthew LeBreton, et al.
Published: (2006-04-01)
by: Matthew LeBreton, et al.
Published: (2006-04-01)
Rift Valley Fever in Namibia, 2010
by: Federica Monaco, et al.
Published: (2013-12-01)
by: Federica Monaco, et al.
Published: (2013-12-01)
Where should we go - Estimating travel times for modelling accessibility to 24-hour emergency departments in Canada
by: Tomoko McGaughey, et al.
Published: (2024-08-01)
by: Tomoko McGaughey, et al.
Published: (2024-08-01)
Laboratory demonstration of the vertical transmission of Rift Valley fever virus by Culex tarsalis mosquitoes.
by: Nicholas A Bergren, et al.
Published: (2021-03-01)
by: Nicholas A Bergren, et al.
Published: (2021-03-01)
The nucleocapsid protein of Rift Valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses.
by: Weidong Xu, et al.
Published: (2013-01-01)
by: Weidong Xu, et al.
Published: (2013-01-01)
Immune correlates of protection following Rift Valley fever virus vaccination
by: Joshua D. Doyle, et al.
Published: (2022-10-01)
by: Joshua D. Doyle, et al.
Published: (2022-10-01)
Yuan:Research on the Fen-wei rift valley
by: Rui Feng
Published: (2025-01-01)
by: Rui Feng
Published: (2025-01-01)
The Risk of Nosocomial Transmission of Rift Valley Fever.
by: Nasser A Al-Hamdan, et al.
Published: (2015-12-01)
by: Nasser A Al-Hamdan, et al.
Published: (2015-12-01)
Outbreak of Rift Valley Fever in Mauritania, 2022
by: Nounengulie Kire, et al.
Published: (2023-11-01)
by: Nounengulie Kire, et al.
Published: (2023-11-01)
Rift Valley Fever Epizootic, Rwanda, 2022
by: Eric Remera, et al.
Published: (2024-10-01)
by: Eric Remera, et al.
Published: (2024-10-01)
Rift Valley Fever, Sudan, 2007 and 2010
by: Imadeldin E. Aradaib, et al.
Published: (2013-02-01)
by: Imadeldin E. Aradaib, et al.
Published: (2013-02-01)
Molecular Epidemiology and Emergence of Rift Valley Fever
by: Sall AA, et al.
Published: (1998-01-01)
by: Sall AA, et al.
Published: (1998-01-01)
Rift Valley Fever, Mayotte, 2007–2008
by: Daouda Sissoko, et al.
Published: (2009-04-01)
by: Daouda Sissoko, et al.
Published: (2009-04-01)
Reemergence of Rift Valley Fever, Mauritania, 2010
by: Ousmane Faye, et al.
Published: (2014-02-01)
by: Ousmane Faye, et al.
Published: (2014-02-01)
Molecular Epidemiology of Rift Valley Fever Virus
by: Antoinette A. Grobbelaar, et al.
Published: (2011-12-01)
by: Antoinette A. Grobbelaar, et al.
Published: (2011-12-01)
An assembly model of Rift Valley fever virus
by: Mirabela eRusu, et al.
Published: (2012-07-01)
by: Mirabela eRusu, et al.
Published: (2012-07-01)
The 2007 Rift Valley fever outbreak in Sudan.
by: Osama Ahmed Hassan, et al.
Published: (2011-09-01)
by: Osama Ahmed Hassan, et al.
Published: (2011-09-01)
Correction: Laboratory demonstration of the vertical transmission of Rift Valley fever virus by Culex tarsalis mosquitoes.
by: Nicholas A Bergren, et al.
Published: (2022-04-01)
by: Nicholas A Bergren, et al.
Published: (2022-04-01)
Correction: Laboratory demonstration of the vertical transmission of Rift Valley fever virus by Culex tarsalis mosquitoes
by: Nicholas A. Bergren, et al.
Published: (2022-04-01)
by: Nicholas A. Bergren, et al.
Published: (2022-04-01)
Efficient Identification of Monoclonal Antibodies Against Rift Valley Fever Virus Using High-Throughput Single Lymphocyte Transcriptomics of Immunized Mice
by: Ronit Rosenfeld, et al.
Published: (2025-02-01)
by: Ronit Rosenfeld, et al.
Published: (2025-02-01)
Non-traditional international assignments, knowledge and innovation: an exploratory study of women's experiences
by: Laia Miralles-Vazquez, et al.
Published: (2015-08-01)
by: Laia Miralles-Vazquez, et al.
Published: (2015-08-01)
Similar Items
-
A highly potent human neutralizing antibody prevents vertical transmission of Rift Valley fever virus in a rat model
by: Cynthia M. McMillen, et al.
Published: (2023-07-01) -
Neutrophil and macrophage influx into the central nervous system are inflammatory components of lethal Rift Valley fever encephalitis in rats.
by: Joseph R Albe, et al.
Published: (2019-06-01) -
Maternal vaccination with live-attenuated Rift Valley fever virus protects offspring via immune transfer
by: Austin T. Hertel, et al.
Published: (2025-07-01) -
Congenital Rift Valley fever in Sprague Dawley rats is associated with diffuse infection and pathology of the placenta.
by: Cynthia M McMillen, et al.
Published: (2022-10-01) -
The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis.
by: Trevor Griesman, et al.
Published: (2024-06-01)
