Intraoperative Administration of Esketamine is Associated with Reduced Opioid Consumption After Laparoscopic Gynecological Surgery: A Randomized Controlled Trial

Chen Huan, Ting Zhang, Yiling Jiang, Shuangyu He, Juying Jin Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Juying Jin, Department of Anesthesiology The First Affiliated Hospital of Chongqing Medical U...

Full description

Bibliographic Details
Published in:	Drug Design, Development and Therapy
Main Authors:	Huan C, Zhang T, Jiang Y, He S, Jin J
Format:	Article
Language:	English
Published:	Dove Medical Press 2025-01-01
Subjects:	esketamine opioids postoperative pain gynecological laparoscopic surgery
Online Access:	https://www.dovepress.com/intraoperative-administration-of-esketamine-is-associated-with-reduced-peer-reviewed-fulltext-article-DDDT

Similar Items

Determining Opioid-Sparing Efficacy of Intraoperative Esketamine After Laparoscopic Gynecological Surgery [Letter]
by: Chen XY, et al.
Published: (2025-05-01)

Effect of Different Doses of Esketamine on Postoperative Recovery in Patients Undergoing Gynecologic Laparoscopic Surgery, a Randomized, Double-Blind, Single-Center Clinical Study
by: Li T, et al.
Published: (2025-04-01)

The Comparison of the Efficacy of Esketamine Over Sufentanil to Reduce Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Prospective, Double-Blind, Randomized Controlled Trial
by: Qiu Z, et al.
Published: (2025-10-01)

Esketamine as an Epidural Adjuvant for Postoperative Analgesia in Gynecological Malignancy Surgery: A Randomized Trial
by: Luo H, et al.
Published: (2025-08-01)

The Opioid-Sparing Effects of Intraoperative Esketamine Combined with Dexmedetomidine During Laparoscopic Major Abdominal Surgery: A Randomized Controlled Double-Blind Trial
by: Wang W, et al.
Published: (2025-03-01)

Intraoperative low-dose esketamine on postoperative quality of recovery in patients undergoing open gynecologic surgery: a double-blinded, parallel-group, placebo- controlled trial
by: Zhi-Yu Geng, et al.
Published: (2025-12-01)

Effect of esketamine-based opioid-sparing anesthesia strategy on postoperative pain and recovery quality in patients undergoing total laparoscopic hysterectomy: A randomized controlled trail
by: Jialei Liu, et al.
Published: (2024-02-01)

Effects of opioid-sparing general anesthesia on postoperative nausea and vomiting in laparoscopic gynecological surgery
by: Sun Woo Nam, et al.
Published: (2024-12-01)

Effect of intraoperative low-dose esketamine infusion on postoperative sleep disturbance after laparoscopic cholecystectomy: a randomized clinical trial
by: Yanan Wu, et al.
Published: (2025-07-01)

Effect of Esketamine-Based Opioid-Sparing Anesthesia Protocol on the Quality of Early Recovery After Urological Surgery: A Randomized Clinical Trial
by: Qi Y, et al.
Published: (2025-03-01)

The ED50 and ED95 of esketamine for preventing early postoperative pain in patients undergoing laparoscopic cholecystectomy: a prospective, double-blinded trial
by: Zhongling Xu, et al.
Published: (2023-11-01)

Esketamine/dexmedetomidine–based opioid-free anesthesia and its association with postoperative bowel and cognitive dysfunction after total laparoscopic hysterectomy
by: Guohua Li, et al.
Published: (2025-08-01)

Opioid-Free Anesthesia with Esketamine Combined with Iliac Fascia Block in Elderly Patients Undergoing Hip Surgery
by: Luo LL, et al.
Published: (2025-04-01)

Comparison of Postoperative Pain and Nausea and Vomiting between Desflurane and Desflurane-remifentanil Anesthesia for Gynecologic Laparoscopic Surgery
by: In Suk Lee, et al.
Published: (2015-03-01)

Effect of intravenous esketamine on postoperative sleep disturbance, anxiety, and depression in elderly patients undergoing laparoscopic abdominal surgery: a randomized controlled trial
by: Haijin Wang, et al.
Published: (2025-03-01)

Opioid-Free Anesthesia for Pain Relief After Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial
by: Yu JM, et al.
Published: (2023-10-01)

Combination of dexmedetomidine and esketamine for postoperative nausea and vomiting in patients undergoing laparoscopic surgery: study protocol for a prospective, randomized, controlled trial
by: Ying Zhou, et al.
Published: (2025-07-01)

Effect of intraoperative noise isolation on postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery: protocol for a randomized controlled trial
by: Chong Fu, et al.
Published: (2025-01-01)

The surgical pathologist and laparoscopic gynecologic surgeries
by: Jashnani Kusum, et al.
Published: (2010-10-01)

Effectiveness of perioperative low-dose esketamine infusion for postoperative pain management in pediatric urological surgery: a prospective clinical trial
by: Yanle Xie, et al.
Published: (2024-02-01)

Sub-anesthetic dose of esketamine decreases postoperative opioid self-administration after spine surgery: a retrospective cohort analysis
by: Hongyu Zheng, et al.
Published: (2024-02-01)

Application of opioid-free general anesthesia for gynecological laparoscopic surgery under ERAS protocol: a non-inferiority randomized controlled trial
by: Liang Chen, et al.
Published: (2023-01-01)

Effect of Perioperative Subanesthetic Dose of Esketamine on Postoperative Recovery Quality in Patients Undergoing Laparoscopic Gastrointestinal Surgery: A Randomised, Double-Blind, Controlled Trial
by: Zhang Y, et al.
Published: (2025-08-01)

Effect of opioid-free anesthesia on postoperative nausea and vomiting after gynecological surgery: a systematic review and meta-analysis
by: Zheng Zhang, et al.
Published: (2024-01-01)

Effect of low-dose esketamine on postoperative quality of recovery in total laparoscopic hysterectomy: a randomized controlled trial
by: Jing Zhang, et al.
Published: (2025-07-01)

Risk analysis of postoperative nausea and vomiting in patients after gynecologic laparoscopic surgery
by: Danzhi Luo, et al.
Published: (2024-09-01)

High-frequency, high-intensity transcutaneous electrical nerve stimulation compared with opioids for pain relief after gynecological surgery: a systematic review and meta-analysis
by: Piasecki Adam, et al.
Published: (2023-10-01)

Effect of A118G (rs1799971) single‐nucleotide polymorphism of the μ‐opioid receptor OPRM1 gene on intraoperative remifentanil requirements in Japanese women undergoing laparoscopic gynecological surgery
by: Ruying Zou, et al.
Published: (2024-09-01)

Efficacy of opioid-free anesthesia in reducing postoperative nausea and vomiting following gynecological laparoscopic surgery: a randomized controlled trial
by: Yanan Shen, et al.
Published: (2025-07-01)

Effect and safety of perioperative ketamine/esketamine administration on postoperative pain and depression after breast cancer surgery: a systematic review and meta-analysis
by: Xinyi Sun, et al.
Published: (2025-03-01)

Opioid-free anesthesia with esketamine-dexmedetomidine versus opioid-based anesthesia with propofol-remifentanil in shoulder arthroscopy: a randomized controlled trial
by: Zhouya Xue, et al.
Published: (2024-08-01)

Efficacy of Intravenous Administration of Esketamine in Preventing and Treating Rebound Pain After Thoracic Paravertebral Nerve Block: A Prospective Randomized, Double-Blind, Placebo-Controlled Trial
by: Zeng X, et al.
Published: (2024-02-01)

Effect of different administration methods of esketamine on postoperative depression in patients undergoing heart valve replacement
by: LI Zongxiao, MA Xin, MA Wenru, NIU Zejun
Published: (2025-06-01)

Postoperative pain management following laparoscopic cholecystectomy-non-opioid approaches: a review
by: Hoda Mohamed Bayoumi, et al.
Published: (2024-09-01)

Efficacy and safety of esketamine hydrochloride injection at different dosages for patients undergoing radical thyroidectomy for thyroid cancer: a randomized trial
by: Yihuan Luo, et al.
Published: (2025-07-01)

Effect of different administration methods of esketamine on postoperative pain after thoracoscopic lung surgery
by: LI Liangyu*, XIN Yan, PENG Xiaoyan, CAO Xi, AI Dengbin
Published: (2024-08-01)

Opioid-Free versus Opioid-Sparing Anesthesia for Postoperative Pain and Early Recovery After Laparoscopic Cholecystectomy: A Randomized Controlled Trial
by: Xiong M, et al.
Published: (2025-04-01)

Effect of esketamine on postoperative analgesia and postoperative delirium in elderly patients undergoing gastrointestinal surgery
by: Jing Liu, et al.
Published: (2024-02-01)

The Relationship of Postoperative Pain and Opioid Consumption to Postoperative Delirium After Spine Surgery
by: Sica R, et al.
Published: (2023-01-01)

Opioid-free anesthesia using a combination of ketamine and dexmedetomidine in patients undergoing laparoscopic cholecystectomy: a randomized controlled trial
by: Vishnuraj K R, et al.
Published: (2024-04-01)