Human autoimmunity at single cell resolution in aplastic anemia before and after effective immunotherapy

Abstract Severe immune aplastic anemia is a fatal disease due to the destruction of marrow hematopoietic cells by cytotoxic lymphocytes, serving as a paradigm for marrow failure syndromes and autoimmune diseases. To better understand its pathophysiology, we apply advanced single cell methodologies,...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Zhijie Wu, Shouguo Gao, Xingmin Feng, Haoran Li, Nicolas Sompairac, Shirin Jamshidi, Desmond Choy, Rita Antunes Dos Reis, Qingyan Gao, Sachiko Kajigaya, Lemlem Alemu, Diego Quinones Raffo, Emma M. Groarke, Shahram Kordasti, Bhavisha A. Patel, Neal S. Young
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s41467-025-60213-6