p38 MAPK Facilitates Crosstalk Between Endoplasmic Reticulum Stress and IL-6 Release in the Intervertebral Disc

Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Olga Krupkova, Aleksandra Sadowska, Takuya Kameda, Wolfgang Hitzl, Oliver Nic Hausmann, Juergen Klasen, Karin Wuertz-Kozak
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-08-01
Subjects:	intervertebral disc inflammation endoplasmic reticulum stress p38 MAPK CHOP GADD153
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01706/full

Similar Items

Hypo-Osmotic Loading Induces Expression of IL-6 in Nucleus Pulposus Cells of the Intervertebral Disc Independent of TRPV4 and TRPM7
by: Aleksandra Sadowska, et al.
Published: (2020-07-01)

Fibronectin Fragments and Inflammation During Canine Intervertebral Disc Disease
by: Manuel Roland Schmidli, et al.
Published: (2020-11-01)

Osmosensing, osmosignalling and inflammation: how intervertebral disc cells respond to altered osmolarity
by: A Sadowska, et al.
Published: (2018-11-01)

The Role of <i>Cutibacterium acnes</i> in Intervertebral Disc Inflammation
by: Bettina Schmid, et al.
Published: (2020-06-01)

The Pathobiology of the Meniscus: A Comparison Between the Human and Dog
by: Olga Krupkova, et al.
Published: (2018-04-01)

Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats
by: O Krupkova, et al.
Published: (2014-11-01)

Micrornas associated with TLR-2-induced inflammation in intervertebral disc pathophysiology
by: Petra Cazzanelli, et al.
Published: (2021-01-01)

The role of miR-155-5p in inflammation and mechanical loading during intervertebral disc degeneration
by: Petra Cazzanelli, et al.
Published: (2024-08-01)

Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models
by: Matthew J. Randall, et al.
Published: (2018-10-01)

Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems
by: Paola Bermudez-Lekerika, et al.
Published: (2024-05-01)

Controversies in regenerative medicine: Should intervertebral disc degeneration be treated with mesenchymal stem cells?
by: Markus Loibl, et al.
Published: (2019-03-01)

Resveratrol Microencapsulation into Electrosprayed Polymeric Carriers for the Treatment of Chronic, Non-Healing Wounds
by: Andrea De Pieri, et al.
Published: (2022-04-01)

Clinical and radiological mid- to long-term investigation of anterior lumbar stand-alone fusion: Incidence of reoperation and adjacent segment degeneration
by: Katrin Stosch-Wiechert, et al.
Published: (2022-01-01)

The role of transient receptor potential channels in joint diseases
by: O Krupkova, et al.
Published: (2017-10-01)

Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity
by: Klawitter Marina, et al.
Published: (2012-08-01)

Effect of curcumin on the genotoxicity induced by alkylating agents
by: İbrahim Hakkı Ciğerci
Published: (2015-06-01)

Electrospray-Based Microencapsulation of Epigallocatechin 3-Gallate for Local Delivery into the Intervertebral Disc
by: Moira Loepfe, et al.
Published: (2019-09-01)

TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells
by: Elena Cambria, et al.
Published: (2020-07-01)

Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL‐4 and IL‐10 in Intervertebral Disc Pathophysiology
by: Paola Bermudez‐Lekerika, et al.
Published: (2025-03-01)

The incidence of adjacent segment degeneration and reoperation after anterior stand-alone fusion of the lumbosacral segment - A prospective clinical and radiological long-term investigation -
by: Katrin Stosch-Wiechert, et al.
Published: (2021-01-01)

Correction: Bermudez-Lekerika et al. Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems. <i>Gels</i> 2024, <i>10</i>, 330
by: Paola Bermudez-Lekerika, et al.
Published: (2024-09-01)

Inflammatory and catabolic signalling in intervertebral discs: The roles of NF-B and MAP Kinases
by: K Wuertz, et al.
Published: (2012-02-01)

The influence of physical and spatial substrate characteristics on endothelial cells
by: Oddny Bjorgvinsdottir, et al.
Published: (2024-06-01)

Sulfated Hydrogels in Intervertebral Disc and Cartilage Research
by: Emily Lazarus, et al.
Published: (2021-12-01)

Differential expression of plasma extracellular vesicles microRNAs and exploration of their association with bone metabolism in childhood trauma participants treated in a psychosomatic clinic
by: Yangyang He, et al.
Published: (2025-02-01)

CHOP upregulation and dysregulation of the mature form of the SNAT2 amino acid transporter in the placentas from small for gestational age newborns
by: Emma Barroso, et al.
Published: (2023-11-01)

Predatory Pricing: Persaingan Harga Minimarket dan Gadde-Gadde dalam Metafora Cerpen
by: Andi Sri Wahyuni
Published: (2015-08-01)

Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration
by: Jishang Huang, et al.
Published: (2023-01-01)

GADD45GIP1 promotes osteosarcoma progression by modulating RPL35 ubiquitination and alleviating endoplasmic reticulum stress via the PERK/eIF2α pathway
by: Zhiqiang Li, et al.
Published: (2025-07-01)

Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily
by: Thomas Bitterli, et al.
Published: (2024-03-01)

pH-Responsive Chitosan/Alginate Polyelectrolyte Complexes on Electrospun PLGA Nanofibers for Controlled Drug Release
by: Jean Schoeller, et al.
Published: (2021-07-01)

Acrylonitrile and Pullulan Based Nanofiber Mats as Easily Accessible Scaffolds for 3D Skin Cell Models Containing Primary Cells
by: Markus Rimann, et al.
Published: (2022-01-01)

Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for Intervertebral Disc Degeneration
by: Dong Wang, et al.
Published: (2022-02-01)

EPO Deficiency Upregulates GADD45b/p38 MAPK Axis, Mediating Schizophrenia‐Related Synaptic and Cognitive Impairments
by: Cuiping Guo, et al.
Published: (2024-12-01)

Autophagy and Endoplasmic Reticulum Stress during Onset and Progression of Arrhythmogenic Cardiomyopathy
by: Mark Pitsch, et al.
Published: (2021-12-01)

Role of endoplasmic reticulum stress in cell apoptosis induced by duck hepatitis A virus type 1 infection
by: Jingjing Lan, et al.
Published: (2025-03-01)

Shrimp Lipid Prevents Endoplasmic Reticulum-Mediated Endothelial Cell Damage
by: Zin Zin Ei, et al.
Published: (2022-10-01)

Regulation of endoplasmic reticulum stress on autophagy and apoptosis of nucleus pulposus cells in intervertebral disc degeneration and its related mechanisms
by: Jiuming Dai, et al.
Published: (2024-04-01)

Microbiome assembly predictably shapes diversity across a range of disturbance frequencies in experimental microcosms
by: Ezequiel Santillan, et al.
Published: (2022-05-01)

Managing Bull Fertility in Beef Cattle Herds
by: Gary R. Hansen
Published: (2019-06-01)