Two New Flavonol Glycosides from Polygala sibirica L. var megalopha Fr.

Two new flavonol glycosides, named polygalin H (1) and polygalin I (2), as well as the known compound polygalin D (3), were isolated from the whole plant of Polygala sibirica L. var megalopha Fr. Their structures were elucidated on the basis of spectroscopic data analysis. These flavonol glycosides...

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Bibliographic Details
Published in:Molecules
Main Authors: Yan-Jie Huang, Ling-Yun Zhou, Jun-Min Wang, Qiang Li, Yuan-Yuan Geng, Hai-Yang Liu, Yan Hua
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Subjects:
Polygala sibirica
Polygalaceae
flavonol glycosides
inhibition of xanthine oxidase
Online Access:http://www.mdpi.com/1420-3049/20/12/19775
Description
Summary:Two new flavonol glycosides, named polygalin H (1) and polygalin I (2), as well as the known compound polygalin D (3), were isolated from the whole plant of Polygala sibirica L. var megalopha Fr. Their structures were elucidated on the basis of spectroscopic data analysis. These flavonol glycosides exhibited strong inhibitory activities against xanthine oxidase in vitro. Their half-maximal inhibitory concentrations (IC50) were calculated, which were 9.48, 8.31, 16.00 μM, respectively.
ISSN:1420-3049

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