Microwave Activation: Highly Efficient Hydrolysis of Hesperidin and Naringin and Synthesis of Their Aglycone Acetates Under Microwave Irradiation
Acidic hydrolysis of Hesperidin and Naringin, furnishing their aglycone moieties Hesperetin and Naringenin, respectively, is reported using sulfuric acid and water as a solvent, under microwave irradiation. This new economical procedure provides flavanones in very good yields, ~90% better than that...
| Published in: | Chemistry Proceedings |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2673-4583/16/1/65 |
| _version_ | 1849451484282880000 |
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| author | Omar Fandougouma Nawel Cheikh Didier Villemin Nathalie Bar |
| author_facet | Omar Fandougouma Nawel Cheikh Didier Villemin Nathalie Bar |
| author_sort | Omar Fandougouma |
| collection | DOAJ |
| container_title | Chemistry Proceedings |
| description | Acidic hydrolysis of Hesperidin and Naringin, furnishing their aglycone moieties Hesperetin and Naringenin, respectively, is reported using sulfuric acid and water as a solvent, under microwave irradiation. This new economical procedure provides flavanones in very good yields, ~90% better than that of acid hydrolysis in reflux. Furthermore, we describe for the first time an efficient synthesis of Hesperetin-triacetate and Naringenin-triacetate from the corresponding flavanones, in the presence of 4-(<i>N</i>,<i>N</i>-dimethylamino)-pyridine DMAP as a catalyst, under microwave irradiation. |
| format | Article |
| id | doaj-art-bdb7ea0141d94370abaedbadea4fcfaa |
| institution | Directory of Open Access Journals |
| issn | 2673-4583 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-bdb7ea0141d94370abaedbadea4fcfaa2025-08-20T03:27:28ZengMDPI AGChemistry Proceedings2673-45832025-01-011616510.3390/ecsoc-28-20187Microwave Activation: Highly Efficient Hydrolysis of Hesperidin and Naringin and Synthesis of Their Aglycone Acetates Under Microwave IrradiationOmar Fandougouma0Nawel Cheikh1Didier Villemin2Nathalie Bar3Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN et Université de Caen Normandie, 14050 Caen, FranceLaboratoire de Catalyse et Synthèse en Chimie Organique (LCSOC), Université de Abou Bekr Belkaid, BP119, Tlemcen 13000, AlgeriaLaboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN et Université de Caen Normandie, 14050 Caen, FranceLaboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN et Université de Caen Normandie, 14050 Caen, FranceAcidic hydrolysis of Hesperidin and Naringin, furnishing their aglycone moieties Hesperetin and Naringenin, respectively, is reported using sulfuric acid and water as a solvent, under microwave irradiation. This new economical procedure provides flavanones in very good yields, ~90% better than that of acid hydrolysis in reflux. Furthermore, we describe for the first time an efficient synthesis of Hesperetin-triacetate and Naringenin-triacetate from the corresponding flavanones, in the presence of 4-(<i>N</i>,<i>N</i>-dimethylamino)-pyridine DMAP as a catalyst, under microwave irradiation.https://www.mdpi.com/2673-4583/16/1/65hesperidinnaringinhesperetinnaringeninDMAPmicrowave |
| spellingShingle | Omar Fandougouma Nawel Cheikh Didier Villemin Nathalie Bar Microwave Activation: Highly Efficient Hydrolysis of Hesperidin and Naringin and Synthesis of Their Aglycone Acetates Under Microwave Irradiation hesperidin naringin hesperetin naringenin DMAP microwave |
| title | Microwave Activation: Highly Efficient Hydrolysis of Hesperidin and Naringin and Synthesis of Their Aglycone Acetates Under Microwave Irradiation |
| title_full | Microwave Activation: Highly Efficient Hydrolysis of Hesperidin and Naringin and Synthesis of Their Aglycone Acetates Under Microwave Irradiation |
| title_fullStr | Microwave Activation: Highly Efficient Hydrolysis of Hesperidin and Naringin and Synthesis of Their Aglycone Acetates Under Microwave Irradiation |
| title_full_unstemmed | Microwave Activation: Highly Efficient Hydrolysis of Hesperidin and Naringin and Synthesis of Their Aglycone Acetates Under Microwave Irradiation |
| title_short | Microwave Activation: Highly Efficient Hydrolysis of Hesperidin and Naringin and Synthesis of Their Aglycone Acetates Under Microwave Irradiation |
| title_sort | microwave activation highly efficient hydrolysis of hesperidin and naringin and synthesis of their aglycone acetates under microwave irradiation |
| topic | hesperidin naringin hesperetin naringenin DMAP microwave |
| url | https://www.mdpi.com/2673-4583/16/1/65 |
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