可生物降解聚合物载体微球口服防龋疫苗免疫效果

【目的】以PAc多肽(301～319)作为抗原,PBLG-PEG-PBLG做载体制备防龋微球疫苗,口服免疫SD大鼠,观察其对变链菌在大鼠牙面的黏附及对龋病发生的影响效果。【方法】28只出生30d的雄性SD大鼠随机分成4组建立龋模型,对各组大鼠口腔中变链菌的黏附菌落计数,根据Keyes评分标准做龋齿记分。【结果】PAc多肽抗原微球疫苗口服组的变形链球菌数为(13.2±8.16)×104CFU/ml;磨牙龋齿Keyes计分为31.8±6.77,均显著低于对照组(P<0.01)。【结论】口服PAc多肽抗原微球防龋疫苗均能减少龋模型大鼠龋齿的发生,以光滑面龋的减少更显著。...

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Bibliographic Details
Published in:	Zhongshan Daxue xuebao. Yixue kexue ban
Main Authors:	刘建伟, 凌均棨
Format:	Article
Language:	Chinese
Published:	Editorial Office of Journal of Sun Yat-sen University 2007-01-01
Subjects:	龋病变形链球菌多肽微球疫苗
Online Access:	http://xuebaoyx.sysu.edu.cn/zh/article/43581736/

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