Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives

• الحاوية / القاعدة: Тонкие химические технологии
• المؤلفون الرئيسيون: A. I. Musin, Yu. G. Borisova, Sh. Sh. Dzhumaev, N. S. Khusnutdinova, G. Z. Raskil’dina, R. M. Sultanova, S. S. Zlotskii
• التنسيق: مقال
• اللغة: الروسية
• منشور في: MIREA - Russian Technological University 2023-10-01
• الموضوعات: 5-acyl-1,3-dioxane; alkylation; ethers; isoniazid; 2,4-dinitrophenyl hydrazine
• الوصول للمادة أونلاين: https://www.finechem-mirea.ru/jour/article/view/1992
• تدمد: 2410-6593; 2686-7575

Objectives. To synthesize derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes and evaluate their effect on platelet aggregation and plasma hemostasis.Methods. To determine the qualitative and quantitative composition of the reaction masses, gas chromatography-, chromate mass spectrometry-, and 1H and 13C nuclear magnetic resonance spectrometry methods were used.Results. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were obtained under thermal heating conditions in order to evaluate their effect on platelet aggregation and plasma hemostasis.Conclusions. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were synthesized in high yields. Their effect on platelet aggregation and plasma hemostasis was established.