Regulation of TIA-1 Condensates: Zn2+ and RGG Motifs Promote Nucleic Acid Driven LLPS and Inhibit Irreversible Aggregation

Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is a key protein in the formation of stress granules that undergoes liquid-liquid phase separation by association with specific RNAs and protein-protein interactions. However, the f...

詳細記述

書誌詳細

出版年:	Frontiers in Molecular Biosciences
主要な著者:	Danella L. West, Fionna E. Loughlin, Francisco Rivero-Rodríguez, Naveen Vankadari, Alejandro Velázquez-Cruz, Laura Corrales-Guerrero, Irene Díaz-Moreno, Jacqueline A. Wilce
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2022-07-01
主題:	TIA1 RNA binding protein liquid-liquid phase separation prion-like domain RRM amyloid fibril
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.960806/full