Mesencephalic astrocyte-derived neurotrophic factor (MANF) prevents the neuroinflammation induced dopaminergic neurodegeneration

Background: The excessive activation of the microglia leads to the release of inflammatory factors that contribute to neuronal cell loss and neurodegeneration in Parkinson's Disease (PD). Mesencephalic astrocyte-derived neurotrophic factor (MANF) that belongs to a newly found neurotrophic facto...

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Bibliographic Details

Published in:	Experimental Gerontology
Main Authors:	Jing-Xing Zhang, Kai-Ge Zhou, Yan-Xin Yin, Ling-Jing Jin, Wei-Fang Tong, Jia Guo, Li-Hua Yu, Xian-Cheng Ye, Ming Jiang
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Subjects:	Parkinson's disease (PD) Mesencephalic astrocyte-derived neurotrophic factor (MANF) Dopaminergic neurodegeneration Neuroinflammation Nrf-2 Microglia activation
Online Access:	http://www.sciencedirect.com/science/article/pii/S0531556522003461