Promising therapeutics of enterovirus 71 infection: sunshine behind cloud
Enterovirus 71 (EV71) infection gave a hard hit on young children because of fatal complication, brainstem encephalitis with pulmonary edema. The occurrence of severe EV71 infections highlight the urgent need for the development and repurposing of novel antivirals for medical use. Drugs target speci...
| 出版年: | Frontiers in Pharmacology |
|---|---|
| 主要な著者: | , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Frontiers Media S.A.
2025-09-01
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| 主題: | |
| オンライン･アクセス: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1652159/full |
| _version_ | 1849264317985193984 |
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| author | Sheng-Yu You Sheng-Yu You Shun-Hua Chen Shun-Hua Chen Shun-Hua Chen Shih-Min Wang Shih-Min Wang Shih-Min Wang |
| author_facet | Sheng-Yu You Sheng-Yu You Shun-Hua Chen Shun-Hua Chen Shun-Hua Chen Shih-Min Wang Shih-Min Wang Shih-Min Wang |
| author_sort | Sheng-Yu You |
| collection | DOAJ |
| container_title | Frontiers in Pharmacology |
| description | Enterovirus 71 (EV71) infection gave a hard hit on young children because of fatal complication, brainstem encephalitis with pulmonary edema. The occurrence of severe EV71 infections highlight the urgent need for the development and repurposing of novel antivirals for medical use. Drugs target specific steps in the cycle of viral replication, and the modification of existing factors in EV71 immunopathogenesis deciphers the current approaches for developing antivirals. In addition to identifying chemical compounds, we highlight active constituents and explore underlying mechanisms of action of antimicrobial peptides and natural products that may be active against EV71 and provide pharmacological benefits. |
| format | Article |
| id | doaj-art-c1925e4a7e094e11adadab5ff8107251 |
| institution | Directory of Open Access Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-c1925e4a7e094e11adadab5ff81072512025-09-16T05:34:18ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-09-011610.3389/fphar.2025.16521591652159Promising therapeutics of enterovirus 71 infection: sunshine behind cloudSheng-Yu You0Sheng-Yu You1Shun-Hua Chen2Shun-Hua Chen3Shun-Hua Chen4Shih-Min Wang5Shih-Min Wang6Shih-Min Wang7Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, TaiwanCenter of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, TaiwanDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, TaiwanCenter of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, TaiwanInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, TaiwanCenter of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, TaiwanCenter for Infection Control, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanSchool of Medicine, College of Medicine, National Cheng Kung University, Tainan, TaiwanEnterovirus 71 (EV71) infection gave a hard hit on young children because of fatal complication, brainstem encephalitis with pulmonary edema. The occurrence of severe EV71 infections highlight the urgent need for the development and repurposing of novel antivirals for medical use. Drugs target specific steps in the cycle of viral replication, and the modification of existing factors in EV71 immunopathogenesis deciphers the current approaches for developing antivirals. In addition to identifying chemical compounds, we highlight active constituents and explore underlying mechanisms of action of antimicrobial peptides and natural products that may be active against EV71 and provide pharmacological benefits.https://www.frontiersin.org/articles/10.3389/fphar.2025.1652159/fullenterovirus 71brainstem encephalitispulmonary edemaantiviralentrovirus |
| spellingShingle | Sheng-Yu You Sheng-Yu You Shun-Hua Chen Shun-Hua Chen Shun-Hua Chen Shih-Min Wang Shih-Min Wang Shih-Min Wang Promising therapeutics of enterovirus 71 infection: sunshine behind cloud enterovirus 71 brainstem encephalitis pulmonary edema antiviral entrovirus |
| title | Promising therapeutics of enterovirus 71 infection: sunshine behind cloud |
| title_full | Promising therapeutics of enterovirus 71 infection: sunshine behind cloud |
| title_fullStr | Promising therapeutics of enterovirus 71 infection: sunshine behind cloud |
| title_full_unstemmed | Promising therapeutics of enterovirus 71 infection: sunshine behind cloud |
| title_short | Promising therapeutics of enterovirus 71 infection: sunshine behind cloud |
| title_sort | promising therapeutics of enterovirus 71 infection sunshine behind cloud |
| topic | enterovirus 71 brainstem encephalitis pulmonary edema antiviral entrovirus |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1652159/full |
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