Promising therapeutics of enterovirus 71 infection: sunshine behind cloud

Enterovirus 71 (EV71) infection gave a hard hit on young children because of fatal complication, brainstem encephalitis with pulmonary edema. The occurrence of severe EV71 infections highlight the urgent need for the development and repurposing of novel antivirals for medical use. Drugs target speci...

Full description

Bibliographic Details
Published in:	Frontiers in Pharmacology
Main Authors:	Sheng-Yu You, Shun-Hua Chen, Shih-Min Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	enterovirus 71 brainstem encephalitis pulmonary edema antiviral entrovirus
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1652159/full

Similar Items

Enterovirus 71, One Virus and Many Stories
by: Shih-Min Wang, et al.
Published: (2008-08-01)

Suppression of interleukin-6 increases enterovirus A71 lethality in mice
by: Li-Chiu Wang, et al.
Published: (2017-12-01)

Fatal Case of Enterovirus 71 Infection, France, 2007
by: Sophie Vallet, et al.
Published: (2009-11-01)

Plasminogen deficiency reduces disease severity and immune responses in enterovirus A71-infected mice
by: Zheng-Xun Li, et al.
Published: (2025-07-01)

Excellent Response to Plasma Exchange in Three Patients With Enterovirus-71 Neurological Disease
by: Elba Pascual-Goñi, et al.
Published: (2019-05-01)

Epidemiology of Enterovirus 71 Infections in Taiwan
by: Min-Yuan Chia, et al.
Published: (2014-08-01)

Antiviral Effect of Matrine against Human Enterovirus 71
by: Jiangning Liu, et al.
Published: (2012-08-01)

Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia
by: Paul F. Horwood, et al.
Published: (2016-01-01)

Enterovirus A71 neurologic complications and long-term sequelae
by: Luan-Yin Chang, et al.
Published: (2019-08-01)

Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy
by: Chiaho Shih, et al.
Published: (2018-11-01)

Enterovirus 71 infection and neurological complications
by: Kyung Yeon Lee
Published: (2016-10-01)

Acute Hemorrhagic Conjunctivitis by Enterovirus 71
by: Brahm Prakash Guliani, et al.
Published: (2011-07-01)

First isolation of enterovirus 71 (EV-71) from Northern Brazil
by: Leticia Martins Lamarão, et al.

Timing of Endotracheal Intubation in Patients with Fulminant Enterovirus 71 Infection
by: Shen-Dar Chen, et al.
Published: (2020-04-01)

Enterovirus A71 Vaccines
by: Mei-Ling Li, et al.
Published: (2021-02-01)

Using Statistical Phylogenetics for Investigation of Enterovirus 71 Genotype A Reintroduction into Circulation
by: Yulia Vakulenko, et al.
Published: (2019-09-01)

A prospective, comparative study of severe neurological and uncomplicated hand, foot and mouth forms of paediatric enterovirus 71 infections
by: Yoann Crabol, et al.
Published: (2017-06-01)

Enterovirus 71 in Taiwan
by: Luan-Yin Chang
Published: (2008-08-01)

Neutralizing Antibodies to Enterovirus 71 in Belém, Brazil
by: Maria de Lourdes C Gomes, et al.
Published: (2002-01-01)

Antiviral Activity of Rhein against Enterovirus 71 through Inhibiting Viral Replication and Stability
by: Zheng-Zong Lai, et al.
Published: (2024-10-01)

Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021
by: Huimin Lian, et al.
Published: (2023-06-01)

Molecular characteristics of the VP1 region of enterovirus 71 strains in China
by: Haiyan Sun, et al.
Published: (2020-08-01)

Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus Replication
by: Qi Xiang, et al.
Published: (2020-07-01)

Insight into the Life Cycle of Enterovirus-A71
by: Qi Liu, et al.
Published: (2025-01-01)

Enterovirus 71 infection: An experience in Korea, 2009
by: Kyung Hyo Kim
Published: (2010-05-01)

Enterovirus 71 Maternal Antibodies in Infants, Taiwan
by: Shu-Ting Luo, et al.
Published: (2009-04-01)

The Repurposing of Cellular Proteins during Enterovirus A71 Infection
by: Sudeshi M. Abedeera, et al.
Published: (2023-12-01)

Enterovirus 71 CNS Infection and ADHD
by: J Gordon Millichap
Published: (2008-09-01)

Genetic Characterization of Enterovirus A71 Circulating in Africa
by: Maria Dolores Fernandez-Garcia, et al.
Published: (2018-04-01)

Enterovirus 71 Outbreak, Brunei
by: Sazaly AbuBakar, et al.
Published: (2009-01-01)

Evaluation of enterovirus 71 immune status in São Paulo state, Brazil
by: Adriana Luchs, et al.
Published: (2010-12-01)

Translation control of Enterovirus A71 gene expression
by: Ming-Chih Lai, et al.
Published: (2020-01-01)

Receptors for enterovirus 71
by: Seiya Yamayoshi, et al.
Published: (2014-01-01)

Targeting Ser78 phosphorylation of Hsp27 achieves potent antiviral effects against enterovirus A71 infection
by: Mandi Wu, et al.
Published: (2024-12-01)

Long-Term Immunogenicity Study of an Aluminum Phosphate-Adjuvanted Inactivated Enterovirus A71 Vaccine in Children: An Extension to a Phase 2 Study
by: Nan-Chang Chiu, et al.
Published: (2024-08-01)

Immunopathogenesis and Virus–Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease
by: Jonathan A. Cox, et al.
Published: (2017-11-01)

Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development
by: Yu-Kang Chang, et al.
Published: (2018-11-01)

A fatal pediatric infection with a C1-like subgenogroup enterovirus A71: case study and enterovirus A71 epidemiology in Finland
by: Tea Nieminen, et al.
Published: (2024-04-01)

Enterovirus A71 Infection and Neurologic Disease, Madrid, Spain, 2016
by: Pascal Del Giudice
Published: (2020-07-01)

Fludarabine Inhibits Infection of Zika Virus, SFTS Phlebovirus, and Enterovirus A71
by: Chengfeng Gao, et al.
Published: (2021-04-01)